This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Genetic studies in pigeonpea (Cajanus cajan (L.) Mill sp) [PDF]
Study was carried out for genetic variability, heritability and genetic advance of twelve characters in fifty white seed coated lines.High coefficient of variation for number of pods, seed yield per plant, plant height and raceme length and high values ...
D.Bhadru
doaj
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Genetic Variability in Bitter Gourd (Momordica charantia L.)
The variance analysis for 17 plant characters showed significant differences. Maximum vine length was recorded in IC-85635A. Significantly higher number of primary branches per vine and internodal length were observed in IC-85639.
Murlee Yadav +3 more
doaj +1 more source
The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Population Structure of a Worldwide Collection of Tropical Japonica Rice Indicates Limited Geographic Differentiation and Shows Promising Genetic Variability Associated with New Plant Type [PDF]
Vikram Jeet Singh +13 more
openalex +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Genetic variability, correlation and path analysis inAshwagandha [Withania somnifera (L.) Dunal] [PDF]
Forty diverse genotypes of Ashwagandha [Withania somnifera (L.)Dunal] were evaluated for 12 quantitative characters. Higher magnitude of genotypic and phenotypic coefficient of variation was recorded for leaf width, number of primary branches per plant ...
Nilesh R. Joshi, M. A. Patel, K.N. Prajapati and A. D. Patel
doaj
Time after time – circadian clocks through the lens of oscillator theory
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source

