Results 81 to 90 of about 233,443 (255)

Evaluating gene by sex and age interactions on cardiovascular risk factors in Brazilian families

BMC Medical Genetics, 2010
Background In family studies, it is important to evaluate the impact of genes and environmental factors on traits of interest. In particular, the relative influences of both genes and the environment may vary in different strata of the population of ...
Krieger José E, de Andrade Mariza, Pereira Alexandre C, Giolo Suely R, Soler Júlia P   +4 more
doaj   +1 more source

Genomic dissection of maternal, additive and non-additive genetic effects for growth and carcass traits in Nile tilapia

Genetics Selection Evolution, 2020
Background The availability of both pedigree and genomic sources of information for animal breeding and genetics has created new challenges in understanding how they can be best used and interpreted. This study estimated genetic variance components based
Rajesh Joshi, Theo H. E. Meuwissen, John A. Woolliams, Hans M. Gjøen   +3 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Genetic Inheritance of Some Important Characters of Sweet Corn

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 2009
Ten early sweet corn inbred lines were studied for estimating components of genetic variance and heritability, using a factorial (m.n + n.m) mating design with reciprocal combinations. The genotype years interactions (G Y) influenced the expression of
Voichita HAS, Ioan HAS
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

BIGFAM - variance components analysis from relatives without genotype

Nature Communications
Estimating variance components of phenotypes provides a fundamental basis for understanding complex traits. However, most existing methods require genotype data, which is costly to obtain and often unavailable, limiting their scalability. To address this
Jaeeun Jerry Lee, Buhm Han
doaj   +1 more source

Computing approximate standard errors for genetic parameters derived from random regression models fitted by average information REML

Genetics Selection Evolution, 2004
Approximate standard errors (ASE) of variance components for random regression coefficients are calculated from the average information matrix obtained in a residual maximum likelihood procedure.
Gilmour Arthur R, Fischer Troy M, Werf Julius   +2 more
doaj   +1 more source

Genetic variance components for female fertility in Iranian Holstein cows

Livestock Science, 2011
Linear and threshold animal models were used to estimate genetic parameters for reproductive traits in Iranian Holstein cows. Reproductive traits included days from calving to first service (DFS), number of inseminations to conception (INS), calving interval (CI), days open (DO), and interval between first and last insemination (IFL), pregnancy rate ...
Ghiasi, H., Pakdel, A., Nejati-Javaremi, A., Mehrabani-Yeganeh, H., Honarvar, M., González-Recio, O., Carabaño, M. J., Alenda, R.   +7 more
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source