Results 91 to 100 of about 1,068,124 (306)

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Disease-Associated Streptococcus pneumoniae Genetic Variation

Emerging Infectious Diseases
Streptococcus pneumoniae is an opportunistic pathogen that causes substantial illness and death among children worldwide. The genetic backgrounds of pneumococci that cause infection versus asymptomatic carriage vary substantially.
Shimin Yang, Jianyu Chen, Jinjian Fu, Jiayin Huang, Ting Li, Zhenjiang Yao, Xiaohua Ye   +6 more
doaj   +1 more source

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

FEBS Letters, EarlyView.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin, Danielle M. Colussi, Peter B. Stathopulos   +2 more
wiley   +1 more source

A genome-wide association study identifies protein quantitative trait loci (pQTLs) [PDF]

, 2008
There is considerable evidence that human genetic variation influences gene expression. Genome-wide studies have revealed that mRNA levels are associated with genetic variation in or close to the gene coding for those mRNA transcripts - cis effects, and ...
A Bennett, Aimo Ruokonen, AL Dixon, AL Dixon, AL Price, Alison Hurst, AM Dunning, Amanda Bennett, Andrew Singleton, Angela Britton, Anna Murray, Anna-Maria Corsi, Anne B. Newman, B Futcher, B Keavney, B Ketterer, BE Stranger, BE Stranger, C Brunner, CJ Boos, Colin Dayan, D Greenbaum, D Il'yasova, D Reich, David Melzer, Dena Hernandez, DH McDermott, E Boerwinkle, E Gonzalez, EJ Foss, Fulvio Lauretani, G Davey Smith, Giuseppe Paolisso, Greg Tranah, Hana Lango, HG Kraft, HH Goring, I Aird, Ian Rafferty, J Mullberg, J. Raphael Gibbs, Jack Guralnik, Javier Simon-Sanchez, JD Storey, John R. B. Perry, Joyce van de Leemput, JS O'Donnell, Kara Stevens, KW Broman, L Ferrucci, Luigi Ferrucci, M Morley, M Ogorelkova, Marjo-Riitta Jarvelin, Mark I. McCarthy, MF Moffatt, Michael N. Weedon, MN Weedon, MR Jarvelin, Neil Rice, Nicole Washecka, NJ Cox, NJ Timpson, P Rantakallio, P Saravanan, Rongling Li, S Rafiq, S Rafiq, Sajjad Rafiq, Sampath Arepalli, SI Berndt, Sonja Scholz, SP Gygi, SP Yip, Stefania Bandinelli, Tamara Harris, Timothy M. Frayling, TM Frayling, TM Frayling, VG Cheung, Vijay Panicker, Vivian G. Cheung, William Henley, WR Pearson, WS Modi   +84 more
core   +5 more sources

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Evidence of widespread selection on standing variation in Europe at height-associated SNPs. [PDF]

, 2012
Strong signatures of positive selection at newly arising genetic variants are well documented in humans(1-8), but this form of selection may not be widespread in recent human evolution(9).
Chiang, Charleston WK, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Hirschhorn, Joel N, Palmer, Cameron D, Reich, David, Sankararaman, Sriram, Turchin, Michael C   +6 more
core   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Divergência genética entre variedades de videiras do Banco Ativo de Germoplasma da Embrapa Semiárido

Revista Ciência Agronômica
RESUMOEste trabalho teve por objetivo avaliar a divergência genética entre 31 variedades de videira do Banco de Germoplasma da Embrapa Semiárido, considerando características de qualidade, compostos de importância funcional e atividade antioxidante dos ...
Patrício Ferreira Batista, Maria Auxiliadora Coêlho de Lima, Patrícia Coelho de Souza Leão, Flávio de França Souza, Ricardo Elesbão Alves   +4 more
doaj   +1 more source

Effect of natural genetic variation on enhancer selection and function. [PDF]

, 2013
The mechanisms by which genetic variation affects transcription regulation and phenotypes at the nucleotide level are incompletely understood. Here we use natural genetic variation as an in vivo mutagenesis screen to assess the genome-wide effects of ...
Allison, KA, Benner, C, Glass, CK, Heinz, S, Kaikkonen, MU, Orozco, LD, Romanoski, CE   +6 more
core  

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, EarlyView.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source