Results 91 to 100 of about 2,022,978 (297)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Genetic–environment associations explain genetic differentiation and variation between western and eastern North Pacific rhinoceros auklet (Cerorhinca monocerata) breeding colonies

Ecology and Evolution
Animals are strongly connected to the environments they live in and may become adapted to local environments. Examining genetic–environment associations of key indicator species, like seabirds, provides greater insights into the forces that drive ...
Brendan A. Graham, J. Mark Hipfner, Kyle W. Wellband, Motohiro Ito, Theresa M. Burg   +4 more
doaj   +1 more source

ASSESSMENT OF GENETIC DIVERSITY OF Solanum lycopersicum var. cerasiforme IN VERACRUZ, MEXICO

Acta Biológica Colombiana
Solanum lycopersicum var. cerasiforme is widely distributed in Veracruz, Mexico, and represents genetic material that must be evaluated as a genetic pool of groups of tomato plants that can be used in a management program. The objective of the study was
Gino Delices, Claudio Mota-Vargas, Ricardo Serna-Lagunes, Pablo Andrés-Meza, Rosalía Núñez-Pastrana, María Elena Galindo Tovar, José Andrés Herrera Corredor, Joaquín Murguía-González, Otto Raúl Leyva-Ovalle   +8 more
doaj   +1 more source

Plant gene bank collections - sources of variation in health substances [PDF]

, 2007
Gene banks and national plant genetic resources programmes have been established to conserve genetic resources of domesticated plants. Variation of the beneficial health substances found in plants is the result of growing conditions (environment) and ...
Antonius, Kristiina
core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Disease-Associated Streptococcus pneumoniae Genetic Variation

Emerging Infectious Diseases
Streptococcus pneumoniae is an opportunistic pathogen that causes substantial illness and death among children worldwide. The genetic backgrounds of pneumococci that cause infection versus asymptomatic carriage vary substantially.
Shimin Yang, Jianyu Chen, Jinjian Fu, Jiayin Huang, Ting Li, Zhenjiang Yao, Xiaohua Ye   +6 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Natural genetic variation in MIR172 isolated from Brassica species

Biologia Plantarum, 2014
The present study reports a natural variation in microRNA172 (MIR172) family members isolated from six species of genus Brassica. The analysis of nucleotide polymorphism across 44 Brassica MIR172 homologs revealed a higher conservation in the predicted ...
S. M. Shivaraj, P. Dhakate, P. Mayee, M. S. Negi, A. Singh   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Genetic variation in Cumbrians

Annals of Human Biology, 1981
Regional variation in the genetic constitution of the Cumbrian population is demonstrated in a survey of blood groups, red cell enzymes, and secretor status in a large sample of schoolchildren. In particular, the south and centre appear to be distinct from the remainder of Cumbria, but in different directions. The features of the central Lake District,
D F, Roberts, R J, Mitchell, C K, Green, L B, Jorde   +3 more
openaire   +2 more sources