Results 111 to 120 of about 2,022,978 (297)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Genetic variability in the Skyros pony and its relationship with other Greek and foreign horse breeds

open access: yesGenetics and Molecular Biology, 2011
In Greece, seven native horse breeds have been identified so far. Among these, the Skyros pony is outstanding through having a distinct phenotype. In the present study, the aim was to assess genetic diversity in this breed, by using different types of ...
Elisabeth Bömcke   +2 more
doaj  

Temperature is a cryptic factor shaping the geographical pattern of genetic variation in Ceratophyllum demersum across a subtropical freshwater lake

open access: yesPlant Diversity
Macrophyte habitats exhibit remarkable heterogeneity, encompassing the spatial variation of abiotic and biotic components such as changes in water conditions and weather as well as anthropogenic stressors.
Yixian Li   +4 more
doaj   +1 more source

Genetic variation between Colletotrichum lindemuthianum isolates

open access: yesPlant Protection Science, 2002
We characterized the genetic diversity of seventy-three C. lindemuthianum isolates collected from 10 different countries by Amplified Fragment Length Polymorphism (AFLP) analysis.
K.I. Ansari   +5 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Phenotypic examination of variation occurring both among families and among genotypes within a T. repens x (T. ambiguum x T. occidentale) BC₁F₂ hybrid population : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Plant Breeding at Massey University, Palmerston North, New Zealand [PDF]

open access: yes, 2017
Development of white clover cultivars with increased vegetative persistence, particularly in dryland farming systems has been a major goal within breeding programmes, however little useful genetic variation for survival and growth in these ...
Slack, Stephen Charles
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Populationsgenetische Differenzierung beim Eichenwickler (Tortrix viridana L.) und seiner Wirtspflanze (Quercus robur L.) anhand nukleärer Genmarker [PDF]

open access: yes, 2008
In Western Europe pedunculate oak (Quercus robur L.) is the forest tree with the highest number of phytophagous insect species (Yela & Lawton 1997). One of these, the green oak leaf roller Tortrix viridana L.
Schröder, Hilke
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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