Results 211 to 220 of about 1,970,763 (233)
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Antimicrobials as promoters of genetic variation
Current Opinion in Microbiology, 2012The main causes of antibiotic resistance are the selection of naturally occurring resistant variants and horizontal gene transfer processes. In recent years, the implications of antibiotic contact or treatment in drug resistance acquisition by bacteria have been gradually more evident.
Jesús Blázquez +3 more
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Genetic variation of regulatory systems
Current Opinion in Genetics & Development, 2009The regulation of gene expression is one of the most important cellular functions that determines developmental and somatic cell fates. Studies that attempt to describe the molecular interactions that govern gene regulation highlight the complexity and multidimensionality of this process.
Dimas, A. S., Dermitzakis, Emmanouil
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Theophylline metabolism: Variation and genetics
Clinical Pharmacology and Therapeutics, 1984Variation of theophylline metabolism in 54 healthy, nonmedicated adults (13 monozygotic [MZ] twin pairs, 11 dizygotic [DZ] twin pairs, and 6 single individuals) was assessed by kinetic study. Elimination rate constant, clearance (Cl), t1/2, and apparent volume of distribution, as well as urine excretion of unchanged theophylline and of the three major ...
Miller, Marvin E. +3 more
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Principles for the Buffering of Genetic Variation
Science, 2001Most genetic research has used inbred organisms and has not explored the complexity of natural genetic variation present in outbred populations. The translation of genotype to phenotype is complicated by gene interactions observed as epistasis, canalization, robustness, or buffering.
Barbara Garvik +2 more
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2009
Publisher Summary This chapter focuses on genetic variability and its applications in entomology. Without change, genome would be passed identically to future generations. But it would also constrain potential future adaptation to new situations. Only when genetic variability is present processes such as selection, genetic drift, and migration can act
George K. Roderick, Maria Navajas
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Publisher Summary This chapter focuses on genetic variability and its applications in entomology. Without change, genome would be passed identically to future generations. But it would also constrain potential future adaptation to new situations. Only when genetic variability is present processes such as selection, genetic drift, and migration can act
George K. Roderick, Maria Navajas
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Molecular genetics of antigenic variation
Immunology Today, 1991Antigenic variation is one of the most effective strategies developed by parasites to escape immune destruction. It requires a large wardrobe of surface coats and mechanisms to exchange one coat for an unrelated one. The molecular principles of antigenic variation are now largely known in the bacterial species Borrelia and Neisseria and in the protozoa
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1991
What processes account for the remarkable variation in form and function that we see in the living world and how might they be similar or different between microorganisms and macroorganisms? Because natural variation provides the raw material on which evolution acts, this chapter sets the stage for later comparisons in the book.
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What processes account for the remarkable variation in form and function that we see in the living world and how might they be similar or different between microorganisms and macroorganisms? Because natural variation provides the raw material on which evolution acts, this chapter sets the stage for later comparisons in the book.
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The Capacity for Genetic Variation
1981The interspecific variation in form in tropical pasture plants (see Figures 3.1–3.14) may cause culture shock to the scientist accustomed to the short, dense leafy swards of temperate climates. The cultivated tropical pasture legumes include trees such as Leucaena leucocephala, twining plants such as Centrosema pubescens capable of climbing 15 m up a ...
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Genetic Variation and Diseases
2008This chapter focuses on bioinformatics aspects of genetic variation research. Because of the diversity of this field, an extensive discussion is provided of the issues involved. The status of genetic variation research is discussed, on the basis of the genotype-to-phenotype relationship.
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1977
A particularly intriguing aspect of the dengue viruses is the extraordinary extent to which they acquire a predilection for growth in the central nervous system (CNS) after “adaptation” to the mouse. Studies to be summarized in this section show that the acquisition of this trait is a process probably involving more than one mutational and selective ...
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A particularly intriguing aspect of the dengue viruses is the extraordinary extent to which they acquire a predilection for growth in the central nervous system (CNS) after “adaptation” to the mouse. Studies to be summarized in this section show that the acquisition of this trait is a process probably involving more than one mutational and selective ...
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