Results 221 to 230 of about 2,035,132 (298)

Gut Microbial Genetic Variation Regulates Host Reproduction. [PDF]

Microb Biotechnol
Ding X, Wu Y, Zhou D, Gu R, Zhu T, Cai W, Ren Y, Li Y, Wang C, Tan A, Li Y, Zhu Z.   +11 more
europepmc   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Genetic variation shapes the chromatin accessibility landscape and transcriptional responses in mouse adipose tissue. [PDF]

PLoS Genet
Mononen J, Taipale M, Malinen M, Levonen AL, Ruotsalainen AK, Norton L, Heikkinen S.   +6 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Exploring standing genetic variation for barley leaf rust resistance in Australian breeding panel. [PDF]

Theor Appl Genet
Pandit M, Dracatos P, Periyannan S, Lam Y, Brunner SM, Honse T, Tong J, Dinglasan E, Ganesalingam D, Moody D, Baraibar S, Hickey L, Alahmad S, Robinson H.   +13 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Common genetic variation influencing the human lung imaging phenotypes. [PDF]

Nat Commun
Zhu M, Du L, Shi L, Ji C, Zhu C, Song C, Wu L, Zhu L, Lu J, Zhang Q, Wu F, Jin C, Mou Y, Li Q, Zhang J, Zhu M, Cai J, Zhang C, Fu Y, Gong L, Hang D, Dai J, Jiang Y, Jin G, Hu Z, Ma H, Cheng X, Shen H.   +27 more
europepmc   +1 more source

Genetic Variation in Wales

Journal of the Royal College of Physicians of London, 1976
openaire   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source