Results 221 to 230 of about 4,640,461 (294)

Quantifying the contribution of genetic variation to healthcare expenditure across diverse healthcare systems

May-Wilson S, Lee J, Nakanishi T, van der Laan C, Louloudis I, Lin K, Kanoni S, Fahr P, Richmond A, Saad C, Lind PA, Al-Kanaani Z, Artomov M, Banasik K, Byrne EM, Chen Z, Erikstrup C, Sørensen E, German J, Brunelli G, Guðbjartsson DF, Þorsteinsdóttir U, Hickie IB, Kolosov N, Koyama S, Kukkonen A, Li L, McCartney DL, Mortensen LH, Ostrowski SR, Pedersen OB, Bundgaard H, Siskind DJ, Speed D, Sulem P, Võrk A, Wordsworth S, Yang Z, Zguro K, Genes & Health Research Team, FinnGen, Medland SE, Martin NG, Mbarek H, Boomsma DI, Marioni RE, Buchanan J, Natarajan P, Finer S, van Heel DA, Walters R, Abner E, Brunak S, Davies NM, Pons TC, Dixon P, Ganna A.   +56 more
europepmc   +1 more source

PharmVar GeneFocus: NAT2-Genetic Variation and Updated Nomenclature. [PDF]

Clin Pharmacol Ther
Papanikolaou G, Poloni ES, Agúndez JAG, Teixeira RLF, Boone EC, Rezende Santos A, Whirl-Carrillo M, Sangkuhl K, Klein TE, Habil MR, Fakis G, Minchin RF, Hein DW, Boukouvala S, Gaedigk A.   +14 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Genetic Variation and Association with Post-Operative Outcomes for Neonates and Infants in the Cardiac Intensive Care Unit. [PDF]

Genes (Basel)
Devine D, Tien A, He H, Baust T, Ghassemzadeh R, Lin JI.   +5 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Not just mutations: inbreeding depression persists without genetic variation. [PDF]

Evol Lett
Bonel N, Grunau C, David P.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Demography and Environment Shapes Genetic Variation: Spatiotemporal Genetic Dynamics in Cyclic Voles at Low Latitudes. [PDF]

Mol Ecol
Domínguez JC, Viñuela J, Olea PP, Calero-Riestra M, García JT.   +4 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Genetic Variation and Evolutionary Characteristics of Coxsackievirus B1: F3 Subtype Associated With Hand, Foot and Mouth Disease in China. [PDF]

J Med Virol
Lin J, Lin X, Yang Q, Ji T, Xiao J, Zhu S, Wang D, Li X, Zhu H, Sun Q, Zhu C, Gao S, Xu Y, Zhang Y, Yan D.   +14 more
europepmc   +1 more source