Results 231 to 240 of about 4,640,461 (294)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Cell-type-resolved genetic variation shapes inflammatory bowel disease risk. [PDF]

Nature
Alegbe T, Harris BT, Fachal L, Ramirez-Navarro L, Tutert M, Krzak M, Ghouraba M, Strickland M, Ozols M, Cohen CE, Khullar S, Khabirova E, Panousis NI, Ochoa D, Wana N, Hu MX, Skelton J, Ostermayer J, Cheam KAX, Leland Taylor D, Gu Y, Dawson C, Thompson T, Arestang K, Nishad N, Brezina B, Caballes CQ, Garri W, Leonard S, Iyer V, Parkes M, Wallace C, McIntyre RE, Martin CC, Jones GR, Raine T, Anderson CA.   +36 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Genetic Variation of <i>MLH1</i> (rs63749820) in Patients With Oral Squamous Cell Carcinoma. [PDF]

Int J Dent
Zare R, Mokhtari MJ, Rahimi H, Fattahi MJ, Khademi B.   +4 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Disentangling host genetic variation for avoidance and resistance to pathogens. [PDF]

BMC Biol
Amoroso CR, Antonovics J.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

High-resolution genotype-free mapping of genetic variation with CRI-SPA-Map. [PDF]

Genome Res
Lutz S, Lawler M, Amidon S, Albert FW.
europepmc   +1 more source

Genetic Variation Analysis of the NSP1 Gene of Type 2 Porcine Reproductive and Respiratory Syndrome Virus in China. [PDF]

Genes (Basel)
Nie T, Li J, Ye S, Wang L, Wang R, Zhao X, Li H, Zhang K, Ye Y, Zhao M.   +9 more
europepmc   +1 more source