Results 61 to 70 of about 2,035,132 (298)

Genetic variation in healthy oldest-old.

PLoS ONE, 2009
Individuals who live to 85 and beyond without developing major age-related diseases may achieve this, in part, by lacking disease susceptibility factors, or by possessing resistance factors that enhance their ability to avoid disease and prolong lifespan.
Julius Halaschek-Wiener, Mahsa Amirabbasi-Beik, Nasim Monfared, Markus Pieczyk, Christian Sailer, Anita Kollar, Ruth Thomas, Georgios Agalaridis, So Yamada, Lisa Oliveira, Jennifer A Collins, Graydon Meneilly, Marco A Marra, Kenneth M Madden, Nhu D Le, Joseph M Connors, Angela R Brooks-Wilson   +16 more
doaj   +1 more source

Genetic diversity and population structure of Thymallus sp. in China based on morphological and molecular markers

Global Ecology and Conservation
Thymallus sp. is a native fish species distributed in the Irtysh River Basin in China. Unfortunately, environmental damage and overfishing have led to a significant decline in Arctic grayling resources, pushing them towards endangerment.
Kai Ma, Guangxiang Tong, Lanlan Zhang, Huizhi Sun, Mingliang Wei, Cheng Zhao, Baoquan He, Jiasheng Yin, Yongquan Zhang   +8 more
doaj   +1 more source

Are current ecological restoration practices capturing natural levels of genetic diversity? A New Zealand case study using AFLP and ISSR data from mahoe (Melicytus ramiflorus) [PDF]

, 2015
Sourcing plant species of local provenance (eco-sourcing) has become standard practice in plant community restoration projects. Along with established ecological restoration practices, knowledge of genetic variation in existing and restored forest ...
Clarke, Andrew C., Clarkson, Fiona Marie, Gemmill, Chrissen E.C., Goshorn, Mary, Stevens, Mark I.   +4 more
core   +2 more sources

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Semantic variation operators for multidimensional genetic programming

, 2019
Multidimensional genetic programming represents candidate solutions as sets of programs, and thereby provides an interesting framework for exploiting building block identification. Towards this goal, we investigate the use of machine learning as a way to
Cava William La, Cava William La, Fine Steven B., James Gareth, McConaghy Trent, Muñoz Luis, Pedregosa Fabian, Silva Sara   +7 more
core   +1 more source

Genetic Risk and Atrial Fibrillation in Patients with Heart Failure [PDF]

, 2020
Aims: To study the association between an atrial fibrillation (AF) genetic risk score with prevalent AF and all-cause mortality in patients with heart failure.
Anker, Stefan D., Artola, Vicente A., Benjamin, Emelia J., Dickstein, Kenneth, Filippatos, Gerasimos S., Kloosterman, Mariëlle, Koekemoer, Andrea, Lam, Carolyn S. P., Lang, Chim, Meer, Peter van der, Metra, Marco, Nelson, Christopher P., Ng, Leong L., Ponikowski, Piotr, Rienstra, Michiel, Romaine, Simon P. R., Roselli, Carolina, Samani, Nilesh J., Santema, Bernadet T., van der Harst, Pim, Van Gelder, Isabelle C., Van Veldhuisen, Dirk Jan, Voors, Adriaan A.   +22 more
core   +3 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Analysis of structural variation among inbred mouse strains

BMC Genomics, 2023
Background ‘Long read’ sequencing methods have been used to identify previously uncharacterized structural variants that cause human genetic diseases.
Ahmed Arslan, Zhuoqing Fang, Meiyue Wang, Yalun Tan, Zhuanfen Cheng, Xinyu Chen, Yuan Guan, Laura J. Pisani, Boyoung Yoo, Gill Bejerano, Gary Peltz   +10 more
doaj   +1 more source

Continental-scale patterns of pathogen prevalence: a case study on the corncrake [PDF]

, 2014
Pathogen infections can represent a substantial threat to wild populations, especially those already limited in size. To determine how much variation in the pathogens observed among fragmented populations is caused by ecological factors, one needs to ...
Barton K., Bates D., Beaumont M. A., Burnham K. P., Coltman D., Goudet J., Green R. E., Green R. E., Schäffer N., Valkiūnas G.   +9 more
core   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source