Results 91 to 100 of about 634,337 (325)
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
4. Gene vectors: Crossing natural barriers to genetic manipulations
California Agriculture, 1982 Not available – first paragraph follows: The potential application of genetic engineering to agriculture has been predicted to be limitless. Such enthusiasm, however, should be expressed judiciously, because much information is needed before we can ...
C Kado
doaj
Gene therapy of malignant glioma with retroviral vectors and tumor-infiltrating progenitor cells [PDF]
, 2008 Gene therapy as a therapeutic strategy in the treatment of human gliomas is limited by the efficacy of gene transfer and intratumoral distribution of viral vectors.
Miletic, Hrvoje
core
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Schistosomiasis: Basic requirements for the development of a subunit vaccine, using genetic vectors. [PDF]
EBioMedicine, 2022 Ahmad G.
europepmc +1 more source
Searching for partial Hadamard matrices [PDF]
, 2010 Three algorithms looking for pretty large partial Hadamard ma- trices are described. Here “large” means that hopefully about a third of a Hadamard matrix (which is the best asymptotic result known so far, [8]) is achieved.
Armario Sampalo, José Andrés +6 more
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Research advances in replication-deficient viral vector vaccines
Frontiers in Veterinary ScienceIn recent years, replication-deficient viral vector vaccines have attracted much attention in the field of vaccine research and development due to their high safety and immunogenicity.
Junna Wang +5 more
doaj +1 more source
An efficient CRISPR vector toolbox for engineering large deletions in Arabidopsis thaliana
Plant Methods, 2018 Background Our knowledge of natural genetic variation is increasing at an extremely rapid pace, affording an opportunity to come to a much richer understanding of how effects of specific genes are dependent on the genetic background.
Rui Wu +9 more
doaj +1 more source