Results 91 to 100 of about 4,784,986 (369)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Construction of Shati/Nat8l Plasmid Vectors, and Analysis of Mitochondrial Function Mediated by Shati/Nat8l Against Amyloid β Toxicity

Neuropsychopharmacology Reports
In Alzheimer's disease (AD), the accumulation of senile plaques composed of neurotoxic amyloid β (Aβ) is known to be one of the causes. Shati/Nat8l, a gene related to neuropsychiatric disorders, encodes an enzyme that biosynthesizes N‐acetyl aspartate ...
Miho Takakuwa, Naotaka Izuo, Kakeru Chino, Yusuke Yano, Jun Yokose, Yuki Shigetsura, Atsumi Nitta   +6 more
doaj   +1 more source

Gene therapy of malignant glioma with retroviral vectors and tumor-infiltrating progenitor cells [PDF]

, 2008
Gene therapy as a therapeutic strategy in the treatment of human gliomas is limited by the efficacy of gene transfer and intratumoral distribution of viral vectors.
Miletic, Hrvoje
core  

Progress in the use of adeno-associated viral vectors for gene therapy [PDF]

, 2004
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Braun-Falco, M., Buning, H., Hallek, M.
core   +1 more source

Towards the genetic control of insect vectors: An overview [PDF]

Entomological Research, 2007
AbstractInsects are responsible for the transmission of major infectious diseases. Recent advances in insect genomics and transformation technology provide new strategies for the control of insect borne pathogen transmission and insect pest management.
Eappen G, Abraham, Sung-Jae, Cha, Marcelo, Jacobs-Lorena   +2 more
openaire   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

ANALYZING BIG DATA WITH DECISION TREES [PDF]

, 2014
ANALYZING BIG DATA WITH DECISION ...
Leong, Lok Kei
core   +1 more source

Biological compatibility between two temperate lineages of brown dog ticks, Rhipicephalus sanguineus (sensu lato) [PDF]

, 2018
Background: The brown dog tick Rhipicephalus sanguineus (sensu stricto) is reputed to be the most widespread tick of domestic dogs worldwide and has also been implicated in the transmission of many pathogens to dogs and humans.
Capelli, Gioia, Dantas-Torres, Filipe, Latrofa, Maria Stefania, Lia, Riccardo Paolo, Otranto, Domenico, Parisi, Antonio, Porretta, Daniele, Ramos, Rafael Antonio Nascimento, Urbanelli, Sandra   +8 more
core   +2 more sources

Malaria Control with Genetically Manipulated Insect Vectors

Science, 2002
At a recent workshop, experts discussed the benefits, risks, and research priorities associated with using genetically manipulated insects in the control of vector-borne diseases.
Alphey L., Beard C., Billingsley P., Coetzee M., CRISANTI, Andrea, Curtis C., Eggleston P., Godfray C., Hemingway J., Jacobs Lorena M., James A., Kafatos F., Mukwaya L., Paton M., Powell J., Schneider W., Scott T., Sina B., Sinkins S., Spielman A., Toure Y., Collins F., Sinden R.   +22 more
openaire   +4 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source