Results 141 to 150 of about 63,159 (270)
Mechanically Programmable DNA Hydrogel Microparticles for 3D Cellular Systems
DNA hydrogel microparticles are designed to exhibit controllable viscoelasticity and stiffness across three orders of magnitude from 30Pa$30 \,\mathrm{Pa}$ to 6.5kPa$6.5 \,\mathrm{kPa}$. They are uptaken into fibroblast spheroids where they are actively remodeled by cellular forces depending on their mechanical properties.
Tobias Walther +9 more
wiley +1 more source
Optimizing Diagnostic Accuracy of Clinical Red Flags in RASopathies
ABSTRACT RASopathies are a group of genetic disorders caused by pathogenic variants in the RAS‐mitogen‐activated protein kinase (RAS–MAPK) signaling pathway, often presenting with congenital heart defects, craniofacial dysmorphisms, and developmental delays. To assess the diagnostic yield of genetic testing in patients with suspected RASopathies and to
Emanuele Bobbio +16 more
wiley +1 more source
Occurrence records are fundamental for ecological and evolutionary research, providing key information on species' geographic ranges. However, these records are often taxonomically, spatially, and temporally biased, requiring caution in their use. Here, we analysed the spatial coverage of occurrence records for over 3500 snake species worldwide to ...
Lívia Frateles +5 more
wiley +1 more source
SNPs in SH3RF3 decrease the age of onset of Alzheimer's disease (AD). Reduced SH3RF3 blunts human microglial JNK and NFkB signaling and downstream inflammatory cytokine production, which may partially explain how SH3RF3 SNPs protect against AD. ABSTRACT Understanding how high‐risk individuals are protected from Alzheimer's disease (AD) may illuminate ...
Ronak Patel +13 more
wiley +1 more source
Salud pública, genética y ética
La investigación genética ha tenido una enorme expansión en recientes décadas, con repercusiones terapéuticas aún inciertas. El análisis bioético tradicional de las complejas prácticas genéticas ha sido insuficiente por sostenerse en la ética de la ...
Kottow Miguel H
doaj
Abstract Background Biofertilization with plant growth‐promoting bacteria (PGPB) is a reliable strategy to reduce the amounts of chemical fertilizers applied to crops. Nevertheless, the effects of biofertilizers on plant chemical constituents that influence food quality and human health should be evaluated.
Pilar Martínez‐Hidalgo +5 more
wiley +1 more source

