Results 171 to 180 of about 131,496 (305)

Predictive evolutionary genomics: principles, validation, and practice

New Phytologist, Volume 252, Issue 1, Page 36-48, October 2026.
Summary Climate change and habitat loss are driving rapid evolutionary responses in populations world‐wide, which creates an urgent need for evolutionary forecasting in conservation and agriculture. Such forecasting can be categorized into three time scales: trait‐based models that use multivariate quantitative genetic equations to project correlated ...
Daniel Ortiz‐Barrientos, Maddie E. James, Yang Liu, Dan Bock, Moisés Exposito‐Alonso, Loren H. Rieseberg   +5 more
wiley   +1 more source

[Genetic Susceptibility to Metabolic Syndrome: A Comparative Overview of the Mexican Population in a Global Context]. [PDF]

Rev Med Inst Mex Seguro Soc
Gallardo-Hernández CA, Díaz-Alberto J, Palma-Jacinto JA, Montero-Ruíz O, Ramírez-Franco U.   +4 more
europepmc   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, Volume 600, Issue 17, Page 2547-2563, September 2026.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Capire Darwin: scienza e società dall''Origine' alla genetica personalizzata

, 2011
Il saggio getta uno sguardo d’insieme sulla lunga durata del fenomeno Darwin, individuando fattori di continuità – ma anche alcuni importanti elementi di discontinuità – nei rapporti che si sono stabiliti tra scienze della vita e società da quando ...
PANCALDI, GIULIANO
core   +1 more source

Genomic profiling of Mexican patients with B‐cell precursor acute lymphoblastic leukemia reveals clinically significant somatic and potential germline variants

The Journal of Pathology: Clinical Research, Volume 12, Issue 5, September 2026.
Abstract B‐cell precursor acute lymphoblastic leukemia (preB‐ALL) is characterized by pathogenic variants currently used in precision oncology. However, the mutational landscape of Mexican children with preB‐ALL has not yet been thoroughly explored and defined in terms of the clinical significance.
Daniel Martínez Anaya, María del Rocío Juárez‐Velázquez, Ulises Juárez Figueroa, Michael Dean, Consuelo Salas Labadía, Marian Valladares Coyotecatl, Adriana Reyes León, Norma López Santiago, Luis Juárez Villegas, Marta Zapata Tarrés, Patricia Pérez‐Vera   +10 more
wiley   +1 more source

Oncogenetics training in Brazilian medical genetics residency programs: current landscape and challenges. [PDF]

J Community Genet
de Queiroz Júnior AF, Acosta AX, Steiner CE, de Souza CAA, Kim CA, Vargas FR, de Andrade MDFC, Correia PS, Zen PRG, Heredia RS, de Faria Ferraz VE, Melo DG, Ashton-Prolla P.   +12 more
europepmc   +1 more source

Seascape Genomics Uncovers Weak Signs of Local Adaptation Despite Bottleneck Events, High Inbreeding and Low Heterozygosity in the Vulnerable Smooth Hammerhead Shark (Sphyrna zygaena)

Aquatic Conservation: Marine and Freshwater Ecosystems, Volume 36, Issue 9, September 2026.
ABSTRACT The smooth hammerhead shark (Sphyrna zygaena) is a highly migratory pelagic predator classified as Vulnerable due to overexploitation and rapid climate change. However, its genomic diversity, connectivity patterns and demographic history remain poorly understood.
Bruno Lopes da Silva Ferrette, Rui Coelho, Rodrigo Rodrigues Domingues, Diego Peres Alonso, Paulo Eduardo Martins Ribolla, Claudio Oliveira, Fernando Fernandes Mendonça   +6 more
wiley   +1 more source

An integrative review of APOL1 kidney disease with a focus on the Brazilian population. [PDF]

Clinics (Sao Paulo)
de Souza CMB, de Oliveira Fam BS, Giudicelli GC, de Menezes Neves PDM, Veronese FV, Vianna FSL.   +5 more
europepmc   +1 more source

Stereodivergent Synthesis of C5‐α‐Substituted Linezolid Derivatives From D‐Mannitol and Structure–Antibacterial Activity Evaluation

Chirality, Volume 38, Issue 9, September 2026.
A stereodivergent route from D‐mannitol enables access to enantiopure C5‐α‐substituted linezolid analogues with full configurational control. Biological evaluation reveals that α‐substitution abolishes antibacterial activity irrespective of stereochemistry, establishing a strict steric limitation at C5 and highlighting the dominant role of substituent ...
José A. Gálvez, Laura Sanz‐Asensio, Ramón Badorrey, Jesús Gonzalo‐Asensio   +3 more
wiley   +1 more source

Genetic Testing in Hypertrophic Cardiomyopathy: Expanding Global Representation While Refining Interpretation. [PDF]

Arq Bras Cardiol
Giugni FR.
europepmc   +1 more source