Results 81 to 90 of about 143,498 (285)

Present day therapy of juvenile idiopathic arthritis with the use of genetically engineered medicines in a third level regional hospital - results and problems

Acta Biomedica Scientifica, 2017
Background. Juvenile idiopathic arthritis is accompanied by severe functional disabilities refractory to standard treatment with methotrexate. Recently introduced genetic engineering has significantly improved the functional state of the patients with ...
A. E. Matyunova, L. V. Bregel
doaj   +1 more source

Antimicrobial functionalized genetically engineered spider silk [PDF]

, 2011
Genetically engineered fusion proteins offer potential as multifunctional biomaterials for medical use. Fusion or chimeric proteins can be formed using recombinant DNA technology by combining nucleotide sequences encoding different peptides or proteins
Aarbiou, Aarbiou, Appendini, Arrondo, Bagheri, Bals, Befus, Bessa, Bessa, Bruschi, Calamai, Campoccia, Cao, Cerpa, Chavakis, Choa, David L. Kaplan, Ericksen, Ferraz, Foo, Foo, Gabriel, Ganz, Grigat, Guerreiro, Hancock, Harris, Harwig, Haynie, Hodgkinson, Hossain, Hu, Huang, Huang, Isabel B. Leonor, Jones, João F. Mano, Kanellakopoulou, Kelly, Kohna, Koliaraki, Krause, Krisanapiboon, Lehrer, Lia, Long, Luo, Mamdal, Mano, Marr, Murphy, Numata, Osbon, Park, Pazgier, Rabotyagova, Rabotyagova, Ramos, Reis, Rui L. Reis, Ruszczak, Santo, Santos, Scheibel, Schlapp, Schneider, Selsted, Shai, Shinto, Smet, Suh, Sílvia C. Gomes, Varkey, Wallace, Wilde, Williams, Wu, Xu, Yan, Yang, Zhang   +80 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

K27-linked RORγt ubiquitination by Nedd4 potentiates Th17-mediated autoimmunity

Journal of Biomedical Science
Background The HECT E3 ubiquitin ligase Nedd4 has been shown to positively regulate T cell responses, but its role in T helper (Th) cell differentiation and autoimmunity is unknown.
Qiuming Zeng, Hui Guo, Na Tang, Pranav S. Renavikar, Nitin J. Karandikar, Amy E. Lovett-Racke, Michael K. Racke, Chengkai Yan, Rong Tang, Sushmita Sinha, Krishnendu Ghosh, Jeremy P. Ryal, Song Ouyang, Min Chen, Foued Amari, Coppola Vincenzo, R. Marshall Pope, Yalan Li, Huan Yang, Wallace Y. Langdon, Jian Zhang   +20 more
doaj   +1 more source

Twenty-eight years of GM Food and feed without harm: why not accept them?

GM Crops & Food
Since the first genetically engineered or modified crops or organisms (GMO) were approved for commercial production in 1995, no new GMO has been proven to be a hazard or cause harm to human consumers.
Richard E. Goodman
doaj   +1 more source

Got Controversy - Milk Does [PDF]

, 2008
This article analyzes ongoing controversy over how to best label rBST-free milk. Recombinant bovine somatotropin is a genetically engineered drug administered by some farmers to their dairy herds to increase milk production. FDA first approved its use in
McCabe, Margaret Sova
core   +1 more source

Immunocompetent murine models for the study of glioblastoma immunotherapy. [PDF]

, 2014
Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in ...
Bloch, Orin, Clark, Aaron J, Fakurnejad, Shayan, Ivan, Michael E, James, Charles D, Oh, Taemin, Parsa, Andrew T, Safaee, Michael, Sayegh, Eli T, Sun, Matthew Z   +9 more
core   +2 more sources

Cryopreservation Protocols for Genetically Engineered Mice

, 2021
Glenn Longenecker, Kyoungin Cho, Jaspal S. Khillan, Ashok B. Kulkarni   +3 more
openalex   +2 more sources

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

RHEUMATIC DISEASES AND TUBERCULOSIS INFECTION IN CHILDREN AND ADULTS

Туберкулез и болезни лёгких, 2019
The authors summarized publications on the risk to develop tuberculosis during the treatment of rheumatic diseases with genetically engineered biologic drugs.
G. V. Santalova, E. A. Borodulina, D. A. Kudlay, D. S. Badaeva, B. E. Borodulin, E. S. Gasilina   +5 more
doaj   +1 more source