Results 151 to 160 of about 8,336,560 (363)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
ISSUES IN DEVELOPMENT AND ADOPTION OF GENETICALLY MODIFIED (GM) WHEATS [PDF]
Development of genetically modified (GM) wheat varieties is proceeding; however, several critical issues remain the focus of contention. This project summarizes the current state of knowledge on some of these critical issues for commercialization of GM ...
Janzen, Edward L. +3 more
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
The Price and Trade Effects of Strict Information Requirements for Genetically Modified Commodities under the Cartagena Protocol on Biosafety [PDF]
The Price and Trade Effects of Strict Information Requirements for Genetically Modified Commodities under the Cartagena Protocol on ...
Antoine BOUET +2 more
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Genetically modified myths and realities
New Biotechnology, 2010 Myths abound when it comes to GE crops. At their worst, myths play an active role in discouraging the use of GE to solve problems that afflict humankind, such as malnutrition and birth defects. Of all the various myths, two have been particularly important in preventing the use of GE maize in its areas of origin. The first is that transgenic maize will
openaire +2 more sources
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
CONSUMER ACCEPTANCE OF GENETICALLY MODIFIED FOODS: A PROFILE OF AMERICAN CONSUMERS [PDF]
A telephone survey was conducted on genetically modified foods in the U.S. Consumers' attitudes are studied using a multiple correspondence analysis, and typology constructed through the use of a cluster analysis.
Ganiere, Pierre, Chern, Wen S.
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Frontiers in Plant ScienceThe C3HC4-type RING finger (Ring-HC) gene family encodes zinc finger proteins crucial for plant growth and stress resistance. However, a comprehensive study on C3HC4-type RING finger genes in cotton has not been conducted to date.
Xue Song +18 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source