Results 171 to 180 of about 8,336,560 (363)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Who Should Certify the Safety of Genetically Modified Foods? [PDF]

Two methods of addressing consumer concerns regarding the use of genetically modified foods are evaluated using conjoint analysis – the use of a familiar brand and government certification.
Mazzocco, Michael A., Baker, Gregory A.
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Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Farm questionnaires for monitoring the cultivation of genetically modified maize

, 2006
The Federal Biological Research Centre for Agriculture and Forestry (BBA), maize breeders and statisticians have worked out a questionnaire for farmers to report on their observations of effects linked to the cultivation of genetically modified crops ...
Schmidt, Kerstin, Schiemann, Joachim, Wilhelm, Ralf   +2 more
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APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Developing a good practice for the review of evidence relevant to GMO risk assessment

, 2013
Recent controversies over peer-reviewed papers on potential impacts of genetically modified organisms underline the necessity for an explicit, transparent and unbiased reviewing of published results. Evidence synthesis approaches represent powerful tools
Kohl, Christian, Kleter, Gijs A., Spök, Armin, Garcia-Yi, Jaqueline, Craig, Wendy, Romeis, Jörg, Wilhelm, Ralf, Frampton, Geoff, van Herck, Kristine, Sweet, Jeremy, Meissle, Michael, Schiemann, Joachim, Krogh, Paul Henning   +12 more
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Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Economics of spatial coexistence of genetically modified and conventional crops: Oilseed rape in Central France [PDF]

Europe is currently struggling to implement coherent coexistence regulations on genetically modified (GM) and non-GM crops in all EU Member States. We conduct simulations with the software ArcView® on a GIS dataset of a hypothetical case of GM herbicide ...
Daems, W., Dillen, Koen, Tollens, Eric, Sausse, C., Demont, Matty, Mathijs, Erik   +5 more
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Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Consumer benefits of labels and bans on genetically modified food - An empirical analysis using Choice Experiments [PDF]

Applying an experiment on the choice of consumer goods, we show that Swedish consumers do not regard genetically modified (GM) food as being equivalent to conventional food. A central argument by proponents of GM is that the end products are identical to
Lagerkvist, Carl Johan, Carlsson, Fredrik, Frykblom, Peter   +2 more
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