Results 261 to 270 of about 226,675 (297)

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Engineering mice for female-biased progeny without impacting genetic integrity and litter size

Qimron U, Yosef I, Mahata T, Xie X, Chen Y, Bar-Joseph H, Sun Q, Shalgi R, Munitz A, Gerlic M.   +9 more
europepmc   +1 more source

Long-Term Latency of Highly Mutated Cells in Normal Mouse Skin Is Reversed by Exposure to Tumor Promoters and Chronic Tissue Damage. [PDF]

Cancer Discov
Li YR, Kandyba E, Halliwill K, Delrosario R, Tran Q, Bayani N, Wu D, Mirzoeva OK, Reeves MQ, Islam SMA, Riva L, Bergstrom EN, Achanta K, DiGiovanni J, Alexandrov LB, Balmain A.   +15 more
europepmc   +1 more source

RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation

Advanced Science, EarlyView.
D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei, Yuhua Zhang, Wei Cao, Nan Cheng, Yun Xiao, Yongjun Zhu, Yan Xu, Lei Zhang, Lingna Guo, Jun Song, Su‐hua Sha, Buwei Shao, Fang Ma, Jingwen Yang, Zheng Ying, Zuhong He, Renjie Chai, Qiaojun Fang, Jianming Yang   +18 more
wiley   +1 more source

Mitochondrial Fusion Protein 2-Modified Bone Marrow Mesenchymal Stem Cells Improved Hyperglycemia-Induced Schwann Cell Injury via Regulating Mitochondria-Associated Endoplasmic Reticulum Membranes. [PDF]

Neurourol Urodyn
Fu H, Ou Z, Wang F, Wang W, Wang Z.
europepmc   +1 more source

Breast cancer preclinical models: a vital resource for comprehending disease mechanisms and therapeutic development. [PDF]

EXCLI J
Kaur R, Sharma A, Wijekoon N.
europepmc   +1 more source

Unprecedented in vivo activity of telacebec against Mycobacterium leprae. [PDF]

PLoS Negl Trop Dis
Chauffour A, Cambau E, Pethe K, Veziris N, Aubry A.   +4 more
europepmc   +1 more source

Creation of Genetically Modified Adipocytes for Tissue Engineering: Creatine Kinase B Overexpression Leads to Stimulated Glucose Uptake and Mitochondrial Potential Growth, but Lowered Lipid Synthesis. [PDF]

Life (Basel)
Michurina S, Beloglazova I, Agareva M, Alekseeva N, Parfyonova Y, Stafeev I.   +5 more
europepmc   +1 more source

Preclinical research models for endometrial cancer: development and selection of animal models. [PDF]

Front Oncol
Xue Y, Shi W, Lun B, Kan M, Jia M, Wu Y, Yang L.   +6 more
europepmc   +1 more source