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Genetically modified mouse as an experimental model in biomedicine
2001no ...
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Genetically Modified Mouse Models for Biomarker Discovery and Preclinical Drug Testing
Clinical Cancer Research, 2012Abstract The ability to grow pluripotent mouse embryonic stem cells in culture, and to introduce precise genetic modifications into those cells through gene targeting, has greatly facilitated the generation of mouse models of human disease. This technology is playing a particularly important role in cancer research.
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Applications and Limitations of Genetically Modified Mouse Models in Drug Discovery and Development
Current Drug Metabolism, 2008Genetically modified mouse models in which a specific gene is removed or replaced have proven to be powerful tools for identification/validation of target gene and scientific understanding of molecular mechanisms underlying drug-induced toxicity through mechanistic studies.
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Histological investigation in the brain of genetically modified mouse of schizophrenia
Neuroscience Research, 2011Norio Ozaki +6 more
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Implantation of genetically modified cerebellar cells into the adult mouse cerebellum
Cell Differentiation and Development, 1989Y. Fujino +6 more
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