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Genetically modified mouse models for premature ovarian failure (POF)
Molecular and Cellular Endocrinology, 2010Premature ovarian failure (POF) is a complex disorder that affects approximately 1% of women. POF is characterized by the depletion of functional ovarian follicles before the age of 40 years, and clinically, patients may present with primary amenorrhea or secondary amenorrhea.
K. Jagarlamudi +3 more
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Genetically modified mouse models in cancer studies
Clinical and Translational Oncology, 2008Genetically modified animals represent a resource of immense potential for cancer research. Classically, genetic modifications in mice were obtained through selected breeding experiments or treatments with powerful carcinogens capable of inducing random mutagenesis.
Javier Santos +4 more
semanticscholar +3 more sources
Genetically Modified Mouse Models for Biomarker Discovery and Preclinical Drug Testing
Clinical Cancer Research, 2012Abstract The ability to grow pluripotent mouse embryonic stem cells in culture, and to introduce precise genetic modifications into those cells through gene targeting, has greatly facilitated the generation of mouse models of human disease. This technology is playing a particularly important role in cancer research.
R. Kucherlapati
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In vivo Studies of the Genetically Modified Mouse Kidney
Nephron Physiology, 2003Gene-targeted mice provide a powerful approach to study the physiological and pathophysiological role of a given protein in kidney function and can give insights on the functional importance of these proteins under in vivo conditions as well as on the potential compensating mechanisms in their absence.
V. Vallon
semanticscholar +3 more sources
PROBABILITY LEARNING IN GENETICALLY MODIFIED MOUSE LINES
Laboratornye Zhivotnye dlya nauchnych issledovanii (Laboratory Animals for Science), 2018A. Tkachenko +3 more
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Noonan syndrome: lessons learned from genetically modified mouse models
Expert Review of Endocrinology & Metabolism, 2017Noonan syndrome is a RASopathy that results from activating mutations in different members of the RAS/MAPK signaling pathway. At least eleven members of this pathway have been found mutated, PTPN11 being the most frequently mutated gene affecting about 50% of the patients, followed by SOS1 (10%), RAF1 (10%) and KRAS (5%). Recently, even more infrequent
Alberto J. Schuhmacher +3 more
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New developments in prion disease research using genetically modified mouse models
Cell and Tissue Research, 2023While much of what we know about the general principles of protein-based information transfer derives from studies of experimentally adapted rodent prions, these laboratory strains are limited in their ability to recapitulate features of human and animal prions and the diseases they produce.
Julianna L. Sun, Glenn C. Telling
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Genetically Modified Mouse Health Reporting: A Need for Global Standardization
Lab Animal, 2003The distribution of GM mice between facilities has raised new problems because of variable microbiological quality. One of the most important management issues concerns the methods of reporting laboratory animal health surveillance results. The authors evaluated the format and content of 380 health reports of mice received from 55 institutions in ...
Juan, Martín-Caballero +2 more
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Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice
2016Highly definable genetically, the humble mouse is the "reagent" mammal of choice with which to probe and begin to understand the human condition in all its complexities. With the recent advance in direct genome editing via targeted nucleases, e.g., TALEN and CRISPR/Cas9, the possibilities in using these sophisticated tools have increased substantially ...
Low, Benjamin E +2 more
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In Vivo Transplantation of Genetically Modified Mouse Embryonic Epidermis
2009Situations in which epidermal mutant mice display early lethality after birth are rather frequent. This condition precludes any kind of analysis of adult or even newborn mice tissues. We propose the in vivo embryonic skin transplantation as an alternative to solve this problem.
Ana Belén, Martínez-Cruz +4 more
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