Results 61 to 70 of about 2,416,740 (342)

Implications of the EFSA Scientific Opinion on Site Directed Nucleases 1 and 2 for Risk Assessment of Genome-Edited Plants in the EU

Agronomy, 2021
Genome editing is a set of techniques for introducing targeted changes in genomes. It may be achieved by enzymes collectively called site-directed nucleases (SDN).
Nils Rostoks
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Killing two birds with one stone: How Au@Pt nanozyme combats liver injury through attenuating oxidative stress and countering inflammation

Materials & Design
Acetaminophen (APAP) overdose remains a leading cause of drug-induced acute liver failure, with existing therapeutic options proving insufficient. Given the central role of oxidative stress and inflammatory cascades in APAP-induced hepatotoxicity, we ...
Yanan Wang, Minrui Kan, Teng Wang, Nan Cheng, Kunlun Huang, Xiaoyun He   +5 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

PCR Based Detection of Genetically Modified Soy in Processed Foods Commercially Available in Saudi Arabia

Sultan Qaboos University Journal for Science, 2009
In this research, PCR (polymerase chain reaction) technique was applied to detect the presence of GMO sold in the Saudi Arabian market. This method was applied to detect genetically modified soy (GM-soy) in particular the roundup ready soy (RRS).
Ibrahim Abdullah Alaraidh
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Environmental risk assessment of genetically modified plants - concepts and controversies [PDF]

, 2011
Background and purpose: In Europe, the EU Directive 2001/18/EC lays out the main provisions of environmental risk assessment (ERA) of genetically modified (GM) organisms that are interpreted very differently by different stakeholders. The purpose of this
Hilbeck, Angelika, Jörg Römbke, Stephan Jänsch, Angelika Hilbeck, Jänsch, Stephan, Römbke, Jörg, Hanka Teichmann, Teichmann, Hanka, Meier, Matthias, Matthias Meier, Beatrix Tappeser, Tappeser, Beatrix   +11 more
core   +1 more source

Coreopsis tinctoria improves energy metabolism in obese hyperglycemic mice

Heliyon
Coreopsis tinctoria (CT) improves energy metabolism. However, the role of CT in alleviating obesity-induced hyperglycemia by targeting the liver remains unknown. Therefore, this article aims to explore the mechanism by which CT improves energy metabolism
Bingxin Huangfu, Minglan Yang, Jia Xu, Ruxin Gao, Yanzhou Hu, Yijia Zhao, Kunlun Huang, Xiaoyun He   +7 more
doaj   +1 more source

Scientific opinion on the presence of DNA in the feed additives consisting of concentrated liquid l‐lysine, l‐lysine monohydrochloride and concentrated liquid l‐lysine monohydrochloride produced by Escherichia coli NITE BP‐02917 for all animal species (METEX NOOVISTAGO)

EFSA Journal, 2023
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on concentrated liquid l‐lysine, l‐lysine monohydrochloride and concentrated liquid
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Boet Glandorf, Montserrat Anguita, Jordi Tarrés‐Call, Elisa Pettenati   +21 more
doaj   +1 more source

Physiologic functions of PP2A: Lessons from genetically modified mice.

Biochimica et biophysica acta. Molecular cell research, 2019
Protein Phosphatase 2A (PP2A) encompasses a large family of Ser/Thr phosphatases, consisting of a catalytic C subunit and a structural A subunit that are, in most cases, further bound to a regulatory B-type subunit. The B-type subunits determine function
S. Reynhout, V. Janssens
semanticscholar   +1 more source