Results 121 to 130 of about 439,037 (382)

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte, Lucy Norcliffe‐Kaufmann, Maria Luisa Cotrina, Zenith Khan, Kaia Dalamo, Patricio Millar Vernetti, Matthew Lawless, Elisabetta Morini, Monica Salani, Marla Weetall, Jana Narasimhan, Agostino G. Rocha, Susan A. Slaugenhaupt, Horacio Kaufmann   +13 more
wiley   +1 more source

Release of genetically modified organisms: precautionary legislation [PDF]

, 1992
Les Levidow, Joyce Tait
openalex   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Viral misinformation and echo chambers: the diffusion of rumors about genetically modified organisms on social media

Internet Research, 2020
Xiaohui Wang, Yunya Song
semanticscholar   +1 more source

LABELING, TRADE AND GENETICALLY MODIFIED ORGANISMS (GMOS): A PROPOSED SOLUTION [PDF]

The purpose of this brief article is to assess the current controversy over Genetically Modified Organisms (GMOs) in agriculture and its potential implications for the global trading system. More importantly, it offers a solution to the serious potential
Jackson, Lee Ann, Runge, C. Ford
core   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Guidance on selection of comparators for the risk assessment of genetically modified plants and derived food and feed

EFSA Journal, 2011
This opinion provides guidance in the area of comparators taking into account the requirements for the molecular characterisation, the food and feed and the environmental risk assessments.
EFSA Panel on Genetically Modified Organisms (GMO)
doaj   +1 more source

Attitudes of the Ecuadorian University Community Toward Genetically Modified Organisms. [PDF]

Front Bioeng Biotechnol, 2021
Román Collazo C, Chacha Guerrero K, Loja Mejia T, Andrade Campoverde D, Hernández Rodriguez Y.   +4 more
europepmc   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Statement on the safety of MON810 maize pollen occurring in or as food

EFSA Journal, 2011
In this statement the EFSA GMO Panel responds to a request from the European Commission on whether data provided within application RX‐MON810 on maize MON810 are sufficient to conclude on the safety of MON810 pollen as or in food and, if it is the case ...
EFSA Panel on Genetically Modified Organisms (GMO)
doaj   +1 more source