Results 171 to 180 of about 7,643,641 (304)

Bioethical questions of medical genetics and reproductive medicine

, 2015
Medical genetics in general is regarded as a science that involves the diagnosis and management of hereditary disorders , however it is met with a lot contradictions due to different ethical issues including the idea that it goes against the laws of ...
Nour Taha, Gerasimchuk, Nina, Theresa Nyathi   +2 more
core  

Correction to: Position Statement of the Indian Academy of Medical Genetics on Next Generation Sequencing-Based Testing for Rare Genetic Disorders. [PDF]

Indian J Pediatr
Shukla A, Bhatia S, Endrakanti M, Gupta D, Moirangthem A, Ranganath P, Executive Committee of the Society for Indian Academy of Medical Genetics (SIAMG).   +6 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Genetic literacy assessment among medical students using the Indonesian adaptation of the University of North Carolina Genomic Knowledge Scale. [PDF]

J Community Genet
Kemal RA, Dhani R, Simanjuntak AM, Rafles AI, Triani HX, Rahmi TM, Akbar VA, Firdaus, Pratama BF, Zulharman.   +9 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Effect of implementation of a clinical checklist on the evaluation of constitutional mismatch repair deficiency in a neurofibromatosis clinic. [PDF]

J Community Genet
McDonald B, Ivanovich J, Wetherill L, Walsh L, Vonbergen J, Langsford L, Rhodes SD, Stout LA.   +7 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Japanese Society for Hereditary Tumors Guidance: Hereditary Cancer Syndromes With Multigene Panel Testing, 2025 Edition. [PDF]

Cancer Sci
Yoshida R, Hirasawa A, Imoto I, Yamaguchi T, Kumamoto K, Araki M, Ueki A, Masuda K, Urakawa Y, Tanabe N, Watanabe A, Hirata M, Aruga T, Kuwata T, Okugawa Y, Kaneko K, Terui-Kohbata H, Matsumoto M, Ueno S, Oda K, Ono H, Sakurai A, Matsui H, Yamamoto G, Yamamoto H, Yamamoto Y, Ikegami M, Ohkuma Y, Shien K, Suzuki S, Takayanagi S, Tanabe M, Hasumi H, Hatta N, Hattori H, Matsubayashi H, Yamagami W, Yamada M, Oishi K, Oka T, Oda S, Kobayashi Y, Takekoshi K, Nakajima T, Nakano Y, Nakayama Y, Miura F, Miyakura Y, Mori Y, Yoshimura A, Yonamine M, Shigeyasu K, Fujita H, Futagawa M, Ohta K, Kawano J, Tokutomi T, Sato A, Makabe T, Yoshihama T, Aitani M, Kimura K, Takaiso N, Tomozawa C, Hiraoka Y, Matsukawa M, Ishida H.   +66 more
europepmc   +1 more source