Results 171 to 180 of about 712,245 (264)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Author Correction: Streptomyces produce a diphtheria toxin-like exotoxin that targets insects. [PDF]

Nat Microbiol
Xu Y, Stubbendieck RM, Viswanatha R, Krč A, Baik LS, Suh WS, Hu Y, Wang H, Yin L, Mameli E, van der Meij A, Carlson JR, Doxey AC, Stenmark P, Perrimon N, Currie CR, Dong M.   +16 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Publisher Correction: Biallelic variants in RNU2-2 cause the most prevalent known recessive neurodevelopmental disorder. [PDF]

Nat Genet
Greene D, Mendez R, Lees J, Barbosa M, Bruselles A, Chiriatti L, Ferraro F, Mancini C, Schot R, Sleutels F, Bertini E, Bonner DE, Bouman A, Brooks AS, Cassini THA, Ezell KM, Gomez-Ospina N, Kleefstra T, O'Donoghue M, Rives L, Shashi V, Spillmann RC, Wafik M, Undiagnosed Diseases Network, Freson K, Barakat TS, Tartaglia M, Bernstein JA, Mumford AD, Wheeler MT, Turro E.   +30 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

A pilot qualitative study of patient understanding and perceptions of genetic counselors and cascade testing in the context of transthyretin cardiac amyloidosis. [PDF]

J Genet Couns
Bui QM, Berninger T, Morales A, Korty L, Allen LA, Adler ED, Urey MA, Hong KN, Rabin B, Bloss C.   +9 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Author Correction: Genome-wide fine-mapping improves identification of causal variants. [PDF]

Nat Genet
Wu Y, Zheng Z, Thibaut L, Lin T, Feng Q, Cheng H, Yengo L, Goddard ME, Wray NR, Visscher PM, Zeng J.   +10 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

European Reference Networks as core health structures where referring genetic newborn screening positive infants: an innovative operational research framework. [PDF]

Front Public Health
Fortunato F, Selvatici R, Kirschner J, Sansen S, Agolini E, Ottombrino S, Bertini E, Novelli A, Einhorn M, Matalonga L, Beltran S, Gut IG, Pereira AM, Hiort O, Schaefer F, Verloes A, Lohse AW, Wilde AAM, Bodemer C, Jondeau G, Dollfus H, Graessner H, Mathijssen IMJ, L'khssim I, Blay JY, Sangiorgi L, Fenaux P, Mañú Pereira MDM, Gutiérrez Valle V, Mosca M, Hoogerbrugge N, Wijnen R, Evangelista T, D'Angelo C, Wagner TOF, Feitz WFJ, Ladenstein R, Dobai Z, Wulffraat N, Ruperto N, Jara Vega P, Bellettato CM, Scarpa M, Onali M, Tchaicha S, Arzimanoglou A, Oh J, Lenz D, Tumiene B, Zygmunt A, Ferlini A.   +50 more
europepmc   +1 more source