Results 181 to 190 of about 6,062,135 (332)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Correction: Association of mir-196a-2 rs11614913 and mir-149 rs2292832 polymorphisms with risk of cancer: an updated meta-analysis. [PDF]

Front Genet
Choupani J, Nariman-Saleh-Fam Z, Saadatian Z, Ouladsahebmadarek E, Masotti A, Bastami M.   +5 more
europepmc   +1 more source

Medical genetics [PDF]

Journal of Medical Genetics, 2005
openaire   +1 more source

CFTR variant testing: a technical standard of the American College of Medical Genetics and Genomics (ACMG)

Genetics in Medicine, 2020
Joshua L. Deignan, C. Astbury, G. Cutting, D. del Gaudio, A. Gregg, W. Grody, K. Monaghan, Sue Richards   +7 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Blueprint for building a patient-centered hereditary cancer program based on stakeholder perspectives. [PDF]

Gynecol Oncol Rep
Soussana TN, Primiano M, Ahsan MD, Baron C, Mitchell L, Sharaf RN, Frey MK.   +6 more
europepmc   +1 more source

The Anatomy to Genomics (ATG) Start Genetics medical school initiative: incorporating exome sequencing data from cadavers used for Anatomy instruction into the first year curriculum. [PDF]

BMC Med Genomics, 2016
Gerhard GS, Jin Q, Paynton BV, Popoff SN.   +3 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Prenatal diagnosis – where do we go from here? [PDF]

Med Genet
Fauth C, Verheyen S.
europepmc   +1 more source

Points to consider for reporting of germline variation in patients undergoing tumor testing: a statement of the American College of Medical Genetics and Genomics (ACMG)

Genetics in Medicine, 2020
Marilyn M. Li, E. Chao, E. Esplin, David T. Miller, K. Nathanson, S. Plon, M. Scheuner, D. Stewart, Acmg Professional Practice and Guidelines Committee   +8 more
semanticscholar   +1 more source