Results 201 to 210 of about 7,643,641 (304)

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Benchmarking five large language models in medical genetics: a bilingual comparative evaluation using published and novel expert-authored questions. [PDF]

Front Med (Lausanne)
Gündoğdu Öğütlü ÖB, Solomon BD, Çelik YS.   +2 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Implementing genetic counselling supervision in southwestern Europe: the MAG-SUDOE programme. [PDF]

J Community Genet
Paneque M, Guimarães L, Sagardia A, Costa I, Alvira-Iraizoz F, Tubío-Fungueiriño M, Dewulf-Pasz N, Villa P, Ramos-Arroyo MA, Fernández-Prieto M.   +9 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Author Correction: Long-read sequencing reveals pre-meiotic gene conversion in sperm. [PDF]

Nature
Schweiger R, Lee S, Zhou C, Yang TP, Li S, Sanghvi R, Neville M, Smith K, Roberts K, Nessa A, Wadge S, Small KS, Campbell PJ, Almstrup K, Sudmant PH, Rahbari R, Durbin R.   +16 more
europepmc   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Correction: <i>UK clinical practice guidelines for the management of patients with constitutional <i>POT1</i> pathogenic variants</i>. [PDF]

J Med Genet
europepmc   +1 more source

From idiopathic pulmonary hemosiderosis to ENaC channelopathy: a novel SCNN1G mutation. [PDF]

Am J Respir Crit Care Med
Peng Q, Jiang Z, Chen Y, Li Y, Zhang F, Yang L, Lai W, Huang X, Wang L, Zeng X, Zhong B, Lu X.   +11 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source