Results 11 to 20 of about 1,279,027 (330)

Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies

open access: yesGut, 2021
Objective Tryptophan can be catabolised to various metabolites through host kynurenine and microbial indole pathways. We aimed to examine relationships of host and microbial tryptophan metabolites with incident type 2 diabetes (T2D), host genetics, diet ...
Q. Qi   +37 more
semanticscholar   +1 more source

Faecalibacterium prausnitzii alleviates inflammatory arthritis and regulates IL-17 production, short chain fatty acids, and the intestinal microbial flora in experimental mouse model for rheumatoid arthritis

open access: yesArthritis Research & Therapy, 2023
Background Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease that leads to joint destruction and functional disability due to the targeting of self-antigens present in the synovium, cartilage, and bone.
Jeonghyeon Moon   +10 more
semanticscholar   +1 more source

Bacillus subtilis spores displaying RBD domain of SARS-CoV-2 spike protein

open access: yesComputational and Structural Biotechnology Journal, 2023
Bacillus subtilis spores are considered to be efficient and useful vehicles for the surface display and delivery of heterologous proteins. In this study, we prepared recombinant spores with the receptor binding domain (RBD) of the SARS-CoV-2 spike ...
A. Vetráková   +4 more
doaj   +1 more source

Microbial metal resistance and metabolism across dynamic landscapes: high-throughput environmental microbiology. [PDF]

open access: yes, 2017
Multidimensional gradients of inorganic compounds influence microbial activity in diverse pristine and anthropogenically perturbed environments. Here, we suggest that high-throughput cultivation and genetics can be systematically applied to generate ...
Carlson, Hans   +2 more
core   +2 more sources

Extending an eco-evolutionary understanding of biofilm-formation at the air-liquid interface to community biofilms [PDF]

open access: yes, 2020
Growing bacterial populations diversify to produce a number of competing lineages. In the Pseudomonas fluorescens SBW25 model system, Wrinkly Spreader mutant lineages, capable of colonising the air-liquid interface of static microcosms by biofilm ...
Jerdan, Robyn   +4 more
core   +3 more sources

Host genetics influence the rumen microbiota and heritable rumen microbial features associate with feed efficiency in cattle

open access: yesMicrobiome, 2019
The symbiotic rumen microbiota is essential for the digestion of plant fibers and contributes to the variation of production and health traits in ruminants.
Fuyong Li   +8 more
semanticscholar   +1 more source

Biochemical characterization of extremozyme L-asparaginase from Pseudomonas sp. PCH199 for therapeutics

open access: yesAMB Express, 2023
L-asparaginase (L-ASNase) from microbial sources is a commercially vital enzyme to treat acute lymphoblastic leukemia. However, the side effects associated with the commercial formulations of L-ASNases intrigued to explore for efficient and desired ...
Sanyukta Darnal   +6 more
doaj   +1 more source

The MpsAB Bicarbonate Transporter Is Superior to Carbonic Anhydrase in Biofilm-Forming Bacteria with Limited CO2 Diffusion

open access: yesMicrobiology Spectrum, 2021
CO2 and bicarbonate are required for carboxylation reactions, which are essential in most bacteria. To provide the cells with sufficient CO2, there exist two dissolved inorganic carbon supply (DICS) systems: the membrane potential-generating system ...
Sook-Ha Fan   +4 more
doaj   +1 more source

Considering Intra-individual Genetic Heterogeneity to Understand Biodiversity [PDF]

open access: yes, 2019
In this chapter, I am concerned with the concept of Intra-individual Genetic Hetereogeneity (IGH) and its potential influence on biodiversity estimates. Definitions of biological individuality are often indirectly dependent on genetic sampling -and vice ...
A Cárdenas-Flores   +69 more
core   +2 more sources

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2017
Significance Identifying the drivers of the interindividual diversity of the human immune system is crucial to understand their consequences on immune-mediated diseases. By examining the transcriptional responses of 1,000 individuals to various microbial
B. Piasecka   +15 more
semanticscholar   +1 more source

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