Results 21 to 30 of about 125,784 (265)

The Devil Is in the Microbial Genetic Details [PDF]

open access: yesMolecular Cell, 2019
The work of Zeevi et al. (2019) in a recent issue of Nature shows that variations in gene content and organization between different strains of the same microbial species are widespread in the human gut microbiota and could be linked to many measures of health.
Adrien, Assié, Buck S, Samuel
openaire   +2 more sources

Late cornified envelope 1C (LCE1C), a transcriptional target of TAp63 phosphorylated at T46/T281, interacts with PRMT5

open access: yesScientific Reports, 2018
p63, a transcriptional factor that belongs to the p53 family, regulates epidermal differentiation, stemness, cell death, tumorigenesis, metastasis, and senescence. However, its molecular mechanism remains elusive. We report here that TAp63 phosphorylated
Norikazu Yabuta   +6 more
doaj   +1 more source

Biochemical characterization of extremozyme L-asparaginase from Pseudomonas sp. PCH199 for therapeutics

open access: yesAMB Express, 2023
L-asparaginase (L-ASNase) from microbial sources is a commercially vital enzyme to treat acute lymphoblastic leukemia. However, the side effects associated with the commercial formulations of L-ASNases intrigued to explore for efficient and desired ...
Sanyukta Darnal   +6 more
doaj   +1 more source

The MpsAB Bicarbonate Transporter Is Superior to Carbonic Anhydrase in Biofilm-Forming Bacteria with Limited CO2 Diffusion

open access: yesMicrobiology Spectrum, 2021
CO2 and bicarbonate are required for carboxylation reactions, which are essential in most bacteria. To provide the cells with sufficient CO2, there exist two dissolved inorganic carbon supply (DICS) systems: the membrane potential-generating system ...
Sook-Ha Fan   +4 more
doaj   +1 more source

mSphere of Influence: Surface Sensing in Biofilm Formation

open access: yesmSphere, 2021
Kara B. De Leόn works in the field of microbial ecology, environmental biofilms, and microbial genetics.
Kara B. De Leόn
doaj   +1 more source

New approaches to combat Porphyromonas gingivalis biofilms

open access: yesJournal of Oral Microbiology, 2017
In nature, bacteria predominantly reside in structured, surface-attached communities embedded in a self-produced, extracellular matrix. These so-called biofilms play an important role in the development and pathogenesis of many infections, as they are ...
Evelien Gerits   +2 more
doaj   +1 more source

Genetically Programmable Microbial Assembly

open access: yesACS Synthetic Biology, 2021
Engineered microbial communities show promise in a wide range of applications, including environmental remediation, microbiome engineering, and synthesis of fine chemicals. Here we present methods by which bacterial aggregates can be directed into several distinct architectures by inducible surface expression of heteroassociative protein domains ...
Mark T. Kozlowski   +3 more
openaire   +3 more sources

Elevated acetate kinase (ackA) gene expression, activity, and biofilm formation observed in methicillin-resistant strains of Staphylococcus aureus (MRSA)

open access: yesJournal of Genetic Engineering and Biotechnology, 2023
Background Staphylococcus aureus spreads its infections through biofilms. This usually happens in the stationary phase of S. aureus growth where it utilizes accumulated acetate as a carbon source via the phosphotrans-acetylase-acetate kinase (Pta-Ack ...
Subbarayudu Suthi   +2 more
doaj   +1 more source

Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy

open access: yesNature Communications, 2020
Bacterial biofilms rely on shared extracellular polymeric substances (EPS) and are often highly tolerant to antibiotics. Here, the authors show in in vitro experiments that Salmonella does not evolve resistance to EPS inhibition because such strains are ...
Lise Dieltjens   +7 more
doaj   +1 more source

A Decade of Plague in Mahajanga, Madagascar: Insights into the Global Maritime Spread of Pandemic Plague

open access: yesmBio, 2013
A cluster of human plague cases occurred in the seaport city of Mahajanga, Madagascar, from 1991 to 1999 following 62 years with no evidence of plague, which offered insights into plague pathogen dynamics in an urban environment.
Amy J. Vogler   +8 more
doaj   +1 more source

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