Results 11 to 20 of about 125,982 (264)

Microbial diversity and the genetic nature of microbial species [PDF]

open access: yesNature Reviews Microbiology, 2008
The earth contains a huge number of largely uncharacterized Bacteria and Archaea. Microbiologists are struggling to summarize their genetic diversity and classify them, which has resulted in heated debates on methods for defining species, mechanisms that lead to speciation and whether microbial species even exist. This Review proposes that decisions on
Achtman, M., Wagner, M.
openaire   +3 more sources

Late cornified envelope 1C (LCE1C), a transcriptional target of TAp63 phosphorylated at T46/T281, interacts with PRMT5

open access: yesScientific Reports, 2018
p63, a transcriptional factor that belongs to the p53 family, regulates epidermal differentiation, stemness, cell death, tumorigenesis, metastasis, and senescence. However, its molecular mechanism remains elusive. We report here that TAp63 phosphorylated
Norikazu Yabuta   +6 more
doaj   +1 more source

Biochemical characterization of extremozyme L-asparaginase from Pseudomonas sp. PCH199 for therapeutics

open access: yesAMB Express, 2023
L-asparaginase (L-ASNase) from microbial sources is a commercially vital enzyme to treat acute lymphoblastic leukemia. However, the side effects associated with the commercial formulations of L-ASNases intrigued to explore for efficient and desired ...
Sanyukta Darnal   +6 more
doaj   +1 more source

The Devil Is in the Microbial Genetic Details [PDF]

open access: yesMolecular Cell, 2019
The work of Zeevi et al. (2019) in a recent issue of Nature shows that variations in gene content and organization between different strains of the same microbial species are widespread in the human gut microbiota and could be linked to many measures of health.
Adrien, Assié, Buck S, Samuel
openaire   +2 more sources

New approaches to combat Porphyromonas gingivalis biofilms

open access: yesJournal of Oral Microbiology, 2017
In nature, bacteria predominantly reside in structured, surface-attached communities embedded in a self-produced, extracellular matrix. These so-called biofilms play an important role in the development and pathogenesis of many infections, as they are ...
Evelien Gerits   +2 more
doaj   +1 more source

mSphere of Influence: Surface Sensing in Biofilm Formation

open access: yesmSphere, 2021
Kara B. De Leόn works in the field of microbial ecology, environmental biofilms, and microbial genetics.
Kara B. De Leόn
doaj   +1 more source

Elevated acetate kinase (ackA) gene expression, activity, and biofilm formation observed in methicillin-resistant strains of Staphylococcus aureus (MRSA)

open access: yesJournal of Genetic Engineering and Biotechnology, 2023
Background Staphylococcus aureus spreads its infections through biofilms. This usually happens in the stationary phase of S. aureus growth where it utilizes accumulated acetate as a carbon source via the phosphotrans-acetylase-acetate kinase (Pta-Ack ...
Subbarayudu Suthi   +2 more
doaj   +1 more source

Genetically Programmable Microbial Assembly

open access: yesACS Synthetic Biology, 2021
Engineered microbial communities show promise in a wide range of applications, including environmental remediation, microbiome engineering, and synthesis of fine chemicals. Here we present methods by which bacterial aggregates can be directed into several distinct architectures by inducible surface expression of heteroassociative protein domains ...
Mark T. Kozlowski   +3 more
openaire   +3 more sources

Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy

open access: yesNature Communications, 2020
Bacterial biofilms rely on shared extracellular polymeric substances (EPS) and are often highly tolerant to antibiotics. Here, the authors show in in vitro experiments that Salmonella does not evolve resistance to EPS inhibition because such strains are ...
Lise Dieltjens   +7 more
doaj   +1 more source

Enhancement of feather degrading keratinase of Streptomyces swerraensis KN23, applying mutagenesis and statistical optimization to improve keratinase activity

open access: yesBMC Microbiology, 2023
In this study, 25 actinomyces isolates were obtained from 10 different poultry farms and tested for their keratinase activity. The isolate with the highest keratinase activity was identified through molecular identification by PCR and sequencing of the ...
Nagwa M. Abd El-Aziz   +2 more
doaj   +1 more source

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