Results 51 to 60 of about 293,982 (305)

Bioconversion of biphenyl to a polyhydroxyalkanoate copolymer by Alcaligenes denitrificans A41

AMB Express, 2020
A polyhydroxyalkanoate (PHA) copolymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)], was biosynthesized from biphenyl as the sole carbon source using Alcaligenes (currently Achromobacter) denitrificans A41.
Taito Yajima, Mizuki Nagatomo, Aiko Wakabayashi, Michio Sato, Seiichi Taguchi, Michihisa Maeda   +5 more
doaj   +1 more source

LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells

Scientific Reports, 2022
The epithelial-to-mesenchymal transition (EMT) is a critical process by which cancer cells acquire malignant features. However, the molecular mechanism and functional implications of EMT and the mesenchymal-to-epithelial transition (MET) in tumor ...
Emi Fujibayashi, Satomi Mukai, Kosuke Torigata, Yumi Ando, Toshihiro Uchihashi, Masami Nozaki, Susumu Tanaka, Masato Okada, Mikihiko Kogo, Hiroshi Nojima, Norikazu Yabuta   +10 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Salmonella stress response systems as targets for anti-virulence strategies

BMC Microbiology
Due to the rapid development of antibiotic resistance, novel strategies to cope with bacterial infections are urgently required. Ideally, these strategies should exert less selection pressure for resistance than traditional antibiotics.
Alshimaa Hassanin, Bram Lories, Hans P. Steenackers   +2 more
doaj   +1 more source

Imidazoles and Quaternary Ammonium Compounds as Effective Therapies against (Multidrug-Resistant) Bacterial Wound Infections

Antibiotics
Background/Objectives: The rise and spread of antimicrobial resistance complicates the treatment of bacterial wound pathogens, further increasing the need for newer, effective therapies.
Lauren Van de Vliet, Thijs Vackier, Karin Thevissen, David Decoster, Hans P. Steenackers   +4 more
doaj   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Integrative metabolomic and transcriptomic analyses reveal key mechanisms of lignan biosynthesis during sesame (Sesamum indicum L.) seed development

BMC Plant Biology
Sesame (Sesamum indicum) is a major oilseed crop known for its substantial amount of natural antioxidants. Lignan is believed to be the primary attribute for the antioxidant properties of sesame. However, information related to lignans in sesame oils are
Bantayehu Bekele, Miguel Gallach, Tilahun Mekonen, Dereje Beyene, Kassahun Tesfaye, Mebeaselassie Andargie   +5 more
doaj   +1 more source

The TOR Regulatory Mechanism Controls the Metabolism of Nitrate and the Fermentation Activity in the Yeast Dekkera bruxellensis GDB 248

Microbiology Research
Dekkera bruxellensis is already known for its great biotechnological potential, part of this due to the ability to assimilate nitrate during fermentation.
Karolini Miranda, Beatriz Câmara de Melo, Gilberto Henriques Teles, Irina Charlot Peña-Moreno, Rafael Barros de Souza, Marcos Antonio de Morais   +5 more
doaj   +1 more source

Florida marine biotechnology: research, development and training capabilities to advance science and commerce [PDF]

, 2001
The level of activity and interest in “marine biotechnology” among Florida university faculty and allied laboratory scientists is reported in this document.
Seaman, William, Whitehouse, Jacquelyn H.   +1 more
core  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source