Results 61 to 70 of about 1,279,027 (330)

LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells

Scientific Reports, 2022
The epithelial-to-mesenchymal transition (EMT) is a critical process by which cancer cells acquire malignant features. However, the molecular mechanism and functional implications of EMT and the mesenchymal-to-epithelial transition (MET) in tumor ...
Emi Fujibayashi, Satomi Mukai, Kosuke Torigata, Yumi Ando, Toshihiro Uchihashi, Masami Nozaki, Susumu Tanaka, Masato Okada, Mikihiko Kogo, Hiroshi Nojima, Norikazu Yabuta   +10 more
doaj   +1 more source

The Dynamic Transition of Persistence toward the Viable but Nonculturable State during Stationary Phase Is Driven by Protein Aggregation

mBio, 2021
Decades of research into bacterial persistence has been unable to fully characterize this antibiotic-tolerant phenotype, thereby hampering the development of therapies effective against chronic infections.
Liselot Dewachter, Celien Bollen, Dorien Wilmaerts, Elen Louwagie, Pauline Herpels, Paul Matthay, Ladan Khodaparast, Laleh Khodaparast, Frederic Rousseau, Joost Schymkowitz, Jan Michiels   +10 more
doaj   +1 more source

Predictive Behavior within Microbial Genetic Networks [PDF]

Topologica, 2008
The homeostatic framework has dominated our understanding of cellular physiology. We question whether homeostasis alone adequately explains microbial responses to environmental stimuli, and explore the capacity of intracellular networks for predictive behavior in a fashion similar to metazoan nervous systems. We show that in silico
Ilias, Tagkopoulos, Yir-Chung, Liu, Saeed, Tavazoie   +2 more
openaire   +3 more sources

Structure, function and diversity of the healthy human microbiome [PDF]

, 2012
Studies of the human microbiome have revealed that even healthy individuals differ remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of this diversity remains unexplained, although diet, environment, host genetics and
Huttenhower, Curtis, Izard, Jacques
core   +1 more source

Genetic drift at expanding frontiers promotes gene segregation [PDF]

, 2007
Competition between random genetic drift and natural selection plays a central role in evolution: Whereas non-beneficial mutations often prevail in small populations by chance, mutations that sweep through large populations typically confer a selective ...
Cavalli-Sforza, Currat, D. R. Nelson, Elena, Hegreness, Kardar, Koshland, McMurray, Murray, O. Hallatschek, P. Hersen, Pennisi, S. Ramanathan, Saito, Schroeder, Shapiro   +15 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Competition between homologous chromosomal DNA and exogenous donor DNA to repair CRISPR/Cas9-induced double-strand breaks in Aspergillus  niger

Fungal Biology and Biotechnology
Background Aspergillus niger is well-known for its high protein secretion capacity and therefore an important cell factory for homologous and heterologous protein production.
Selina Forrer, Mark Arentshorst, Prajeesh Koolth Valappil, Jaap Visser, Arthur F. J. Ram   +4 more
doaj   +1 more source

Bioconversion of biphenyl to a polyhydroxyalkanoate copolymer by Alcaligenes denitrificans A41

AMB Express, 2020
A polyhydroxyalkanoate (PHA) copolymer, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)], was biosynthesized from biphenyl as the sole carbon source using Alcaligenes (currently Achromobacter) denitrificans A41.
Taito Yajima, Mizuki Nagatomo, Aiko Wakabayashi, Michio Sato, Seiichi Taguchi, Michihisa Maeda   +5 more
doaj   +1 more source

Microbial diversity and the genetic nature of microbial species [PDF]

Nature Reviews Microbiology, 2008
The earth contains a huge number of largely uncharacterized Bacteria and Archaea. Microbiologists are struggling to summarize their genetic diversity and classify them, which has resulted in heated debates on methods for defining species, mechanisms that lead to speciation and whether microbial species even exist. This Review proposes that decisions on
Achtman, M., Wagner, M.
openaire   +3 more sources

Improved Network Performance via Antagonism: From Synthetic Rescues to Multi-drug Combinations [PDF]

, 2010
Recent research shows that a faulty or sub-optimally operating metabolic network can often be rescued by the targeted removal of enzyme-coding genes--the exact opposite of what traditional gene therapy would suggest.
Adilson E. Motter, Baba, Blagosklonny, Bollenbach, Bourgeois, Burgard, Burgard, Cagatay, Chait, Cun, Dancey, Duarte, Edwards, Feist, Fischer, Fong, Fong, Fong, Fong, Fraenkel, Gerdes, Giaever, Goebl, Harrison, Hashimoto, Hegreness, Henry, Herring, Hilgetag, Hilgetag, Hillenmeyer, Hopkins, Huttenlocher, Huttenlocher, Isalan, Kauffman, Keiser, Kim, Kitano, Kupiec, Ma, Miller, Motter, Motter, Nishikawa, Olson, Palsson, Papp, Pharkya, Reguly, Segre, Segre, Shlomi, Timmermans, Wagner, Yeh, Yildirim, Yngvadottir, Zamboni   +58 more
core   +3 more sources