Results 61 to 70 of about 291,455 (281)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The role of the essential GTPase ObgE in regulating lipopolysaccharide synthesis in Escherichia coli

Nature Communications
During growth, cells need to synthesize and expand their envelope, a process that requires careful regulation. Here, we show that the GTPase ObgE of E.
Liselot Dewachter, Babette Deckers, Israel Mares-Mejía, Elen Louwagie, Silke Vercauteren, Paul Matthay, Simon Brückner, Anna-Maria Möller, Franz Narberhaus, Sibylle C. Vonesch, Wim Versées, Jan Michiels   +11 more
doaj   +1 more source

Widespread movement of invasive cattle fever ticks (Rhipicephalus microplus) in southern Texas leads to shared local infestations on cattle and deer

Parasites & Vectors, 2014
Background Rhipicephalus (Boophilus) microplus is a highly-invasive tick that transmits the cattle parasites (Babesia bovis and B. bigemina) that cause cattle fever. R.
Joseph D Busch, Nathan E Stone, Roxanne Nottingham, Ana Araya-Anchetta, Jillian Lewis, Christian Hochhalter, John R Giles, Jeffrey Gruendike, Jeanne Freeman, Greta Buckmeier, Deanna Bodine, Roberta Duhaime, Robert J Miller, Ronald B Davey, Pia U Olafson, Glen A Scoles, David M Wagner   +16 more
doaj   +1 more source

Membrane depolarization-triggered responsive diversification leads to antibiotic tolerance

Microbial Cell, 2015
Bacterial populations are known to harbor a small fraction of so-called persister cells that have the remarkable ability to survive treatment with very high doses of antibiotics.
Natalie Verstraeten, Wouter Joris Knapen, Maarten Fauvart, Jan Michiels   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Competition quenching strategies reduce antibiotic tolerance in polymicrobial biofilms

npj Biofilms and Microbiomes
Bacteria typically live in dense communities where they are surrounded by other species and compete for a limited amount of resources. These competitive interactions can induce defensive responses that also protect against antimicrobials, potentially ...
Bram Lories, Tom E. R. Belpaire, Bart Smeets, Hans P. Steenackers   +3 more
doaj   +1 more source

Compatibility of Site-Specific Recombination Units between Mobile Genetic Elements

iScience, 2020
Summary: Site-specific recombination (SSR) systems are employed for transfer of mobile genetic elements (MGEs), such as lysogenic phages and integrative conjugative elements (ICEs).
Shota Suzuki, Miki Yoshikawa, Daisuke Imamura, Kimihiro Abe, Patrick Eichenberger, Tsutomu Sato   +5 more
doaj   +1 more source

Genome analysis of Cephalotrichum gorgonifer and identification of the biosynthetic pathway for rasfonin, an inhibitor of KRAS dependent cancer

Fungal Biology and Biotechnology, 2023
Background Fungi are important sources for bioactive compounds that find their applications in many important sectors like in the pharma-, food- or agricultural industries.
Andreas Schüller, Lena Studt-Reinhold, Harald Berger, Lucia Silvestrini, Roman Labuda, Ulrich Güldener, Markus Gorfer, Markus Bacher, Maria Doppler, Erika Gasparotto, Arianna Gattesco, Michael Sulyok, Joseph Strauss   +12 more
doaj   +1 more source

The biotechnology of higher fungi - current state and perspectives [PDF]

, 2014
This review article concisely describes methodology of biotechnological processes with the use of cultures of higher fungi, their application in bioremediation and to obtain biologically active preparations.
Turło, Jadwiga
core   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source