Results 81 to 90 of about 7,457,933 (340)

Demographic history and genomics of local adaptation in blue tit populations

Evolutionary Applications, 2020
Understanding the genomic processes underlying local adaptation is a central aim of modern evolutionary biology. This task requires identifying footprints of local selection but also estimating spatio‐temporal variations in population demography and ...
Charles Perrier, Quentin Rougemont, Anne Charmantier   +2 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Imputation Estimators Partially Correct for Model Misspecification [PDF]

, 2010
Inference problems with incomplete observations often aim at estimating population properties of unobserved quantities. One simple way to accomplish this estimation is to impute the unobserved quantities of interest at the individual level and then take ...
Minin, Vladimir N., O'Brien, John D., Seregin, Arseni   +2 more
core   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Coalescence 2.0: a multiple branching of recent theoretical developments and their applications [PDF]

, 2014
Population genetics theory has laid the foundations for genomics analyses including the recent burst in genome scans for selection and statistical inference of past demographic events in many prokaryote, animal and plant species.
Lemaire, Christophe, Tellier, Aurelien
core   +5 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

The contribution of statistical physics to evolutionary biology

, 2011
Evolutionary biology shares many concepts with statistical physics: both deal with populations, whether of molecules or organisms, and both seek to simplify evolution in very many dimensions.
Ao, Baake, Baake, Bak, Barton, Barton, Barton, Barton, Barton, Barton, Bauer, Beaumont, Boltzmann, Bürger, Callen, Crow, Davis, de Vladar, Demetrius, Demetrius, Derrida, Eigen, Elena, Ewens, Ewens, Fisher, Fisher, Fisher, Fisher, Frank, Frieden, Galtier, Gavrilets, Geyer, Haldane, Haldane, Hallatschek, Hallatschek, Hallatschek, Hamilton, Harold P. de Vladar, Hastings, Hermisson, Iwasa, Judson, Kauffman, Kimura, Kimura, Kimura, Kimura, Kimura, Kolmogorov, Kolmogorov, Kolmogorov, Korolev, Lande, Lande, Leibler, Livnat, Luria, Lynch, Mackay, Maynard-Smith, Maynard-Smith, Metropolis, Mustonen, Neher, Nicholas H. Barton, Peck, Peck, Penna, Price, Prügel-Bennett, Ralph, Rattray, Rouhani, Rouzine, Rouzine, Schrödinger, Sella, Shannon, Sneppen, Szymura, Taylor, Timofeéff-Ressovsky, Watkins, Wilke, Worden, Wright, Wright, Wright, Wright   +91 more
core   +1 more source

MEGA3: Integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment

Briefings Bioinform., 2004
With its theoretical basis firmly established in molecular evolutionary and population genetics, the comparative DNA and protein sequence analysis plays a central role in reconstructing the evolutionary histories of species and multigene families ...
Sudhir Kumar, K. Tamura, M. Nei
semanticscholar   +1 more source

The Etruscans: A Population-Genetic Study [PDF]

The American Journal of Human Genetics, 2004
The origins of the Etruscans, a non-Indo-European population of preclassical Italy, are unclear. There is broad agreement that their culture developed locally, but the Etruscans' evolutionary and migrational relationships are largely unknown. In this study, we determined mitochondrial DNA sequences in multiple clones derived from bone samples of 80 ...
C. Vernesi, D. Caramelli, I. Dupanloup, G. Bertorelle, M. Lari, E. Cappellini, J. Moggi-Cecchi, B. Chiarelli, L. Castri, CASOLI, ANTONELLA, F. Mallegni, C. Lalueza-Fox, G. Barbujani   +12 more
openaire   +6 more sources

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source