Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Expression of Concern: Protein Under-Wrapping Causes Dosage Sensitivity and Decreases Gene Duplicability. [PDF]
PLoS Genetics, 2015 PLOS Genetics Editors
doaj +1 more source
Implementing genetics clinic for hereditary cancer in resource-constrained settings: a narrative review. [PDF]
J Community GenetRungta A +11 more
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Correction: Genetic Mechanism of Human Neutrophil Antigen 2 Deficiency and Expression Variations. [PDF]
PLoS Genetics, 2015 PLOS Genetics Staff
doaj +1 more source
The science and legacies of Ronald Phillips: A brief perspective. [PDF]
Plant GenomeFlavell RB.
europepmc +1 more source
Development of a human genetics-guided priority score for 19,365 genes and 399 drug indications
Áine Duffy +16 more
openalex +2 more sources
Evolutionary genetics of cytoplasmic incompatibility genescifAandcifBin prophage WO ofWolbachia [PDF]
, 2017 Amelia R. I. Lindsey +5 more
openalex +1 more source
Pathway paradigms revealed from the genetics of inflammatory bowel disease
Nature, 2020 D. Graham, R. Xavier
semanticscholar +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source