Results 161 to 170 of about 1,386,700 (294)

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

Molecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva, Bernardo Orr, Ana Azeredo, Andreia Brandão, Manuel R. Teixeira, Paula Paulo   +5 more
wiley   +1 more source

Correction: CAPER Is Vital for Energy and Redox Homeostasis by Integrating Glucose-Induced Mitochondrial Functions via ERR-α-Gabpa and Stress-Induced Adaptive Responses via NF-κB-cMYC. [PDF]

PLoS Genetics, 2015
PLOS Genetics Staff
doaj   +1 more source

Why Hereditas leads hereditary cancer awareness now more than ever. [PDF]

Hereditas
Kazi JU, Massoumi R.
europepmc   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Correction: The Escherichia coli Small Protein MntS and Exporter MntP Optimize the Intracellular Concentration of Manganese. [PDF]

PLoS Genetics, 2015
PLOS Genetics Staff
doaj   +1 more source

A training program to extend the reach of the deciphering developmental disorders in Africa (DDD-Africa) study. [PDF]

Front Genet
Charles A, Lombard Z, Carstens N, Goliath Z, Lumaka A, Makay P, Louw N, Kerr R, Govender D, Krause A, Devriendt K.   +10 more
europepmc   +1 more source

A Study of the Genetics of Galactosaemia [PDF]

, 1955
A. Holzel, G. M. Komrower
openalex   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Correction: Fungal Infection Induces Sex-Specific Transcriptional Changes and Alters Sexual Dimorphism in the Dioecious Plant Silene latifolia. [PDF]

PLoS Genetics, 2015
PLOS Genetics Staff
doaj   +1 more source

Genetic literacy among surgeons who manage patients with cancer: a national survey of knowledge, perceptions, attitudes, and barriers. [PDF]

Can J Surg
Fei LYN, Messiha S, Mir ZM, Dinchong R, Rusnak A, Cofie N, Dalgarno N, Cheifetz RE, Merchant SJ.   +8 more
europepmc   +1 more source