Results 111 to 120 of about 272,074 (162)
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The Molecular Genetics of Sex Determination and Sex Reversal in Mammals
Seminars in Reproductive Medicine, 2012The process of sex determination in mammals normally unfolds in three distinct stages: (1) establishment of chromosomal sex at fertilization (XX or XY); (2) commitment to the appropriate pathway of gonadal differentiation with respect to chromosomal sex, through the action (or absence) of the Y chromosome gene SRY; and (3) correct development of ...
Peter Koopman, Alex Quinn
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Journal of Neuroscience Research, 2021
Abstract This review aims to give an overview of what has been discovered so far and what still needs to be analyzed about how sex and gender affect the disease development. These two terms are often confused and indifferently used. In principle, the term “sex” refers to biological differences between males and females, specifically ...
Chiara, Reale +3 more
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Abstract This review aims to give an overview of what has been discovered so far and what still needs to be analyzed about how sex and gender affect the disease development. These two terms are often confused and indifferently used. In principle, the term “sex” refers to biological differences between males and females, specifically ...
Chiara, Reale +3 more
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Molecular Genetics of Sex Determination
Seminars in Reproductive Medicine, 2002In humans, the choice between male or female development is genetically determined. Sex determination take place when the bipotential embryonic gonad becomes either testis or ovary. This process is directed by genes that have been discovered by genetic analysis of sex-reversed patients and confirmed by knockout experiments in mice.
Cotinot, Corinne +3 more
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Journal of Mental Science, 1962
It is more than twenty years since Lang advanced the hypothesis that some male homosexuals are sex intergrades with male morphological sex characteristics but a female chromosomal pattern (Lang, 1940). Is there now sufficient evidence to prove or disprove the theory?
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It is more than twenty years since Lang advanced the hypothesis that some male homosexuals are sex intergrades with male morphological sex characteristics but a female chromosomal pattern (Lang, 1940). Is there now sufficient evidence to prove or disprove the theory?
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Genetic mechanisms of sex differentiation
Current Opinion in Pediatrics, 1996Cloning of the SRY sex-determining locus on the Y chromosome has stimulated research on the genetic mechanisms of sex determination. It now appears that SRY is not the only gene required for testicular differentiation; X-linked and autosomal genes are also important.
N, Josso, R, Rey
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Genetic sex determination and extinction
Trends in Ecology & Evolution, 2006Genetic factors can affect the probability of extinction either by increasing the effect of detrimental variants or by decreasing the potential for future adaptive responses. In a recent paper, Zayed and Packer demonstrate that low variation at a specific locus, the complementary sex determination (csd) locus in Hymenoptera (ants, bees and wasps), can ...
Philip W, Hedrick +2 more
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Genetics of Sex Differences in Immunity
2023Women have a stronger immune response and a higher frequency of most autoimmune diseases than men. While much of the difference between men and women is due to the effect of gonadal hormones, genetic differences play a major role in the difference between the immune response and disease frequencies in women and men.
Shani T, Gal-Oz, Tal, Shay
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The roles of sex and genetics in the MPN
2022The Philadelphia chromosome negative myeloproliferative neoplasms(MPNs), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are acquired hematopoietic stem cell disorders driven by activating mutations of intracellular signal transduction pathways that control the production of circulating blood cells.
Alison R, Moliterno, Evan M, Braunstein
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