Results 21 to 30 of about 16,868 (148)

International law-making and the Geneva Declaration on Human Rights at Sea

Leiden Journal of International Law
The Geneva Declaration on Human Rights at Sea is a recent initiative of the non-governmental organization (NGO), Human Rights at Sea, and provides an opportunity to examine how an NGO-led initiative may contribute to international law-making.
Natalie Klein
doaj   +1 more source

Model‐Informed Drug Development of a Sustained Release Formulation of Flucytosine in the Treatment of Cryptococcal Meningitis: A Case Study Using Physiologically Based Pharmacokinetic Modeling

CPT: Pharmacometrics & Systems Pharmacology
This paper presents a case study demonstrating the application of model‐informed drug development (MIDD) and early modeling integration in the development of a sustained release (SR) formulation of flucytosine for cryptococcal meningoencephalitis (CM) in
Johanna Eriksson, Erik Sjögren, Jean‐Yves Gillon, Henri Caplain, Vishal Goyal, Vijay Satam, Stephen Robinson, Isabela Ribeiro, Marylore Chenel   +8 more
doaj   +1 more source

Giving regenerative agriculture an agronomic perspective: a proposed framework from the food and beverage industry

Frontiers in Sustainable Food Systems
Food systems face significant challenges that include increasing demand for agricultural products and accelerating environmental degradation. Regenerative agriculture has emerged as concept to reduce environmental harm while maintaining or even improving
Dominik Klauser, Julia de Candido, Alexa Clark, Yves Leclerc, Iver Drabaek, Margaret Henry, Sarah Lockwood, Rebecca Thomson, Joanna Lawrence, Martina Henry, Pascal Chapot, Lucas Urbano, Robyn Cooper, Dionys Forster   +13 more
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Immunotherapeutic Strategies as Potential Treatment Options for Cutaneous Leishmaniasis

Vaccines
Cutaneous leishmaniasis (CL), caused by protozoan parasites of the Leishmania genus, is prevalent in tropical and subtropical regions, with important morbidity, particularly in low- to middle-income countries.
Andrea Lafleur, Stephane Daffis, Charles Mowbray, Byron Arana   +3 more
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Bioavailability of three novel oral, sustained‐release pellets, relative to an immediate‐release tablet containing 500 mg flucytosine: A randomized, open‐label, crossover study in healthy volunteers

Clinical and Translational Science
The opportunistic fungal infection cryptococcal meningoencephalitis is a major cause of death among people living with HIV in sub‐Saharan Africa. We report pharmacokinetic (PK) and safety data from a randomized, four‐period crossover phase I trial of ...
Vishal Goyal, Edrich Krantz, Francois Simon, Anouk Neven, Johanna Eriksson, Amaria Saayman, Nabila Ibnou Zekri Lassout, Mathieu Louis, Stephen Robinson, Abhijit Deshmukh, Amit Antarkar, Carol Ruffell, Sarika Victor, Marylore Chenel, Aljosa Celebic, Henri Caplain, Jean‐Yves Gillon, Isabela Ribeiro   +17 more
doaj   +1 more source

Research and development of new tuberculosis vaccines: a review [version 2; referees: 3 approved, 1 approved with reservations]

F1000Research, 2019
Tuberculosis kills more people worldwide than any other single infectious disease agent, a threat made more dire by the spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). Development of new vaccines capable of preventing TB disease and
Lewis K. Schrager, Rebecca C. Harris, Johan Vekemans   +2 more
doaj   +1 more source

Meaningful Engagement of Persons Affected by Leprosy in Research: An Exploration of Its Interpretation, Barriers, and Opportunities

Tropical Medicine and Infectious Disease, 2023
Despite the growing interest in public and patient involvement in research, best practices in the leprosy context have yet to be explored. This mixed-method study aimed to explore the interpretation, barriers and opportunities of meaningful engagement of
Laura de Groot, Anna T. van ‘t Noordende, Mathias Duck, Joshua Oraga, Sarju Sing Rai, Ruth M. H. Peters, Nienke Veldhuijzen   +6 more
doaj   +1 more source

Research and development of new tuberculosis vaccines: a review [version 1; referees: 2 approved, 1 approved with reservations]

F1000Research, 2018
Tuberculosis kills more people worldwide than any other single infectious disease agent, a threat made more dire by the spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). Development of new vaccines capable of preventing TB disease and
Lewis K. Schrager, Rebecca C. Harris, Johan Vekemans   +2 more
doaj   +1 more source

How gains for SRHR in the UN have remained possible in a changing political climate

Sexual and Reproductive Health Matters, 2020
As right-wing populist movements make electoral gains around the world, one might expect that resultant policy and legislative reversals against sexual and reproductive health and rights (SRHR) would be mirrored by a similar backlash in United Nations ...
Erin Aylward, Stuart Halford
doaj   +1 more source

Assessing the accuracy of health facility typology in representing the availability of health services: a case study in Mali

BMJ Open
Introduction Using health facility types as a measure of service availability is a common approach in international standards for health system policy and planning. However, this proxy may not accurately reflect the actual availability of specific health
Nicolas Ray, Fleur Hierink, Ibrahima-Soce Fall, Samuel Petragallo, Pablo Timoner, Caroline Fuhrer, Ousmane Toure, Akory Iknane, Youssouf Coulibaly   +8 more
doaj   +1 more source