Results 31 to 40 of about 16,868 (148)

Chagas disease research and development: Is there light at the end of the tunnel?

Computational and Structural Biotechnology Journal, 2017
Chagas disease, or American trypanosomiasis, is the result of infection by the parasite Trypanosoma cruzi. It is endemic in Latin America, and spreading around the globe due to human migration.
Eric Chatelain
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Untapped potential of post‐exposure prophylaxis in sub‐Saharan Africa: a comparative analysis of PEP implementation planning in Kenya, Mozambique, Nigeria, Uganda and Zambia

Journal of the International AIDS Society
Introduction In 2023, over 210,000 new HIV acquisitions occurred in Kenya, Mozambique, Nigeria, Uganda and Zambia. While uptake of oral pre‐exposure prophylaxis (oral PrEP) and coverage of voluntary medical male circumcision increased significantly over ...
Danielle Resar, Ambele Judith Mwamelo, Adebanjo Olowu, Janeen Drakes, Helder Macul, Eduarda de Gusmao, Julie Franks, Nere Otubu, Oluwakemi Osowale, Opeyemi Abudiore, Trevor Mwamba, Madaliso Silondwa, Prudence Haimbe, Hilda Shakwelele, Elo Otobo, Richard Borain, Marian Honu, Chidera Chizaram Igbomezie, Christopher Obermeyer, Tasha Vernon, Karin Hatzold, Heather Ingold, Michelle Rodolph, Sarah Yardly Jenkins   +23 more
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Bioavailability of a novel sustained‐release pellet formulation of 5‐flucytosine in healthy‐fed participants for use in patients with cryptococcal meningitis

Clinical and Translational Science
Cryptococcal meningoencephalitis (CM) is an opportunistic fungal infection and a major cause of death among people living with human immunodeficiency virus in sub‐Saharan Africa.
Nabila Ibnou Zekri Lassout, Vishal Goyal, Edrich Krantz, Francois Simon, Anouk Neven, Johanna Eriksson, Amaria Saayman, Vijay Satam, Carol Ruffell, Sarika Victor, Marylore Chenel, Aljosa Celebic, Henri Caplain, Jean‐Yves Gillon, Abhijit Deshmukh, Amit Antarkar, Eric Sjögren, Isabela Ribeiro   +17 more
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The early market access vehicle – An innovative demand-driven model to catalyse introduction of new optimal health products in low- and middle-income countries

Health Policy Open
Low-and middle-income countries (LMICs) account for a significant proportion of the burden of disease for communicable illnesses globally; with malaria, tuberculosis (TB), and HIV/AIDS being the leading causes of death.
Ademola Osigbesan, Ikechukwu Amamilo, Aayush Solanki, Robert Matiru, James Conroy, Alya Omar, Karin Hatzold, Carolyn Amole, Kehinde Onasanya, Janet Ginnard   +9 more
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Pour une géographie des espaces poreux. Polymorphie et polysémie des communautés fermées

Articulo: Journal of Urban Research, 2012
This eighth delivery of Articulo - Journal of Urban Research – which includes communications from the Colloquium titled "The gated communities, between residential innovation and fortification", organized in 2011 on the initiative of the Braillard ...
Christophe Mager, Laurent Matthey
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Field sales force model to increase adoption of a novel tuberculosis diagnostic test among private providers: evidence from India

BMJ Global Health, 2020
Background Impact of novel high-quality tuberculosis (TB) tests such as Xpert MTB/RIF has been limited due to low uptake among private providers in high-burden countries including India.
Harkesh Dabas, Sarang Deo, Manisha Sabharwal, Aparna Parulkar, Ritu Singh, Rigveda Kadam, Puneet Dewan, Pankaj Jindal   +7 more
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Translational Pharmacokinetic‐Pharmacodynamic Modeling and Efficacious Human Dose Prediction of DNDI‐6148 for the Treatment of Cutaneous Leishmaniasis

Clinical and Translational Science
Cutaneous leishmaniasis is a neglected tropical disease with only one oral treatment option. DNDI‐6148 is an orally bioavailable compound with potent antiparasitic activity in preclinical studies.
Rasmus Hansen Henninger, Wietse M. Schouten, Byron Arana, Jean‐Yves Gillon, Charles E. Mowbray, Jadel Müller Kratz, Katrien Van Bocxlaer, Thomas P. C. Dorlo   +7 more
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Predicting consumer intention to buy tiger bone glue in Vietnam: A comparison between the theory of planned behavior and the social cognitive theory

Conservation Science and Practice
Demand for tiger parts and products, especially tiger bone glue, has fuelled the illegal tiger trade and the proliferation of tiger farms in some Asian countries.
Hoai Nam Dang Vu, Louise Taylor, Simone Haysom, Martin Reinhardt Nielsen   +3 more
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The consequence of COVID-19 on the global supply of medical products: Why Indian generics matter for the world? [version 1; peer review: 3 approved, 1 approved with reservations]

F1000Research, 2020
While the world is facing the urgency of the COVID-19 pandemic, policymakers must plan for the direct response to the outbreak while minimising its collateral impact.
Philippe J Guerin, Sauman Singh-Phulgenda, Nathalie Strub-Wourgaft   +2 more
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Evaluation of Drug–Drug Interaction Potential Between the Oral Antibiotic Zoliflodacin and the CYP3A4 Inhibitor Itraconazole: A Phase 1 Study in Healthy Participants

Clinical and Translational Science
Zoliflodacin is a first‐in‐class oral spiropyrimidinetrione antibiotic being developed for patients with uncomplicated gonorrhea, including those infected with multidrug‐resistant strains.
Alison Luckey, Kajal B. Larson, Noha Rayad, Markus Heep, Sophie Delhomme, Gabrielle Kornmann, John P. Mueller, John P. O'Donnell, Seamus O'Brien, Rainard Fuhr, Jean‐Yves Gillon   +10 more
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