Results 31 to 40 of about 262,806 (309)

Vocational Rehabilitation and Employment of People With Disabilities: Report of a European Conference [PDF]

, 2004
[From Overview] The European Conference on Vocational Rehabilitation and Employment of Persons with Disabilities was held in Warsaw, Poland, on 23-25 October 2003.
International Labour Organization, Republic of Poland, Ministry of Economy, Labour and Social Policy   +1 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Immunotherapeutic Strategies as Potential Treatment Options for Cutaneous Leishmaniasis

Vaccines
Cutaneous leishmaniasis (CL), caused by protozoan parasites of the Leishmania genus, is prevalent in tropical and subtropical regions, with important morbidity, particularly in low- to middle-income countries.
Andrea Lafleur, Stephane Daffis, Charles Mowbray, Byron Arana   +3 more
doaj   +1 more source

Research and development of new tuberculosis vaccines: a review [version 2; referees: 3 approved, 1 approved with reservations]

F1000Research, 2019
Tuberculosis kills more people worldwide than any other single infectious disease agent, a threat made more dire by the spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). Development of new vaccines capable of preventing TB disease and
Lewis K. Schrager, Rebecca C. Harris, Johan Vekemans   +2 more
doaj   +1 more source

Meaningful Engagement of Persons Affected by Leprosy in Research: An Exploration of Its Interpretation, Barriers, and Opportunities

Tropical Medicine and Infectious Disease, 2023
Despite the growing interest in public and patient involvement in research, best practices in the leprosy context have yet to be explored. This mixed-method study aimed to explore the interpretation, barriers and opportunities of meaningful engagement of
Laura de Groot, Anna T. van ‘t Noordende, Mathias Duck, Joshua Oraga, Sarju Sing Rai, Ruth M. H. Peters, Nienke Veldhuijzen   +6 more
doaj   +1 more source

Timor link, no. 9, March 1987 [PDF]

, 1987
Contents: The church challenged: Document - an appeal for church unity, Letter - Mgr Belo under surveillance, Solidarity - bishops write to the Timorese church, Document - extracts from Mgr Belo's first pastoral letter -- News from inside: Round-up, The ...

core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Bioavailability of three novel oral, sustained‐release pellets, relative to an immediate‐release tablet containing 500 mg flucytosine: A randomized, open‐label, crossover study in healthy volunteers

Clinical and Translational Science
The opportunistic fungal infection cryptococcal meningoencephalitis is a major cause of death among people living with HIV in sub‐Saharan Africa. We report pharmacokinetic (PK) and safety data from a randomized, four‐period crossover phase I trial of ...
Vishal Goyal, Edrich Krantz, Francois Simon, Anouk Neven, Johanna Eriksson, Amaria Saayman, Nabila Ibnou Zekri Lassout, Mathieu Louis, Stephen Robinson, Abhijit Deshmukh, Amit Antarkar, Carol Ruffell, Sarika Victor, Marylore Chenel, Aljosa Celebic, Henri Caplain, Jean‐Yves Gillon, Isabela Ribeiro   +17 more
doaj   +1 more source

Research and development of new tuberculosis vaccines: a review [version 1; referees: 2 approved, 1 approved with reservations]

F1000Research, 2018
Tuberculosis kills more people worldwide than any other single infectious disease agent, a threat made more dire by the spread of drug-resistant strains of Mycobacterium tuberculosis (Mtb). Development of new vaccines capable of preventing TB disease and
Lewis K. Schrager, Rebecca C. Harris, Johan Vekemans   +2 more
doaj   +1 more source

Strengthening the World Trade Organization – Critical Demands for Imperative Success: Identifying Politically Viable Options for Incremental Reform [PDF]

, 2018
The multilateral trade regime and the World Trade Organization (WTO) are a major success story of global governance. In few other domains have states managed to cooperate as successfully in the last 70 years as in global trade affairs.
Basedow, Robert
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