Results 51 to 60 of about 262,806 (309)

Assessing the accuracy of health facility typology in representing the availability of health services: a case study in Mali

BMJ Open
Introduction Using health facility types as a measure of service availability is a common approach in international standards for health system policy and planning. However, this proxy may not accurately reflect the actual availability of specific health
Nicolas Ray, Fleur Hierink, Ibrahima-Soce Fall, Samuel Petragallo, Pablo Timoner, Caroline Fuhrer, Ousmane Toure, Akory Iknane, Youssouf Coulibaly   +8 more
doaj   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Untapped potential of post‐exposure prophylaxis in sub‐Saharan Africa: a comparative analysis of PEP implementation planning in Kenya, Mozambique, Nigeria, Uganda and Zambia

Journal of the International AIDS Society
Introduction In 2023, over 210,000 new HIV acquisitions occurred in Kenya, Mozambique, Nigeria, Uganda and Zambia. While uptake of oral pre‐exposure prophylaxis (oral PrEP) and coverage of voluntary medical male circumcision increased significantly over ...
Danielle Resar, Ambele Judith Mwamelo, Adebanjo Olowu, Janeen Drakes, Helder Macul, Eduarda de Gusmao, Julie Franks, Nere Otubu, Oluwakemi Osowale, Opeyemi Abudiore, Trevor Mwamba, Madaliso Silondwa, Prudence Haimbe, Hilda Shakwelele, Elo Otobo, Richard Borain, Marian Honu, Chidera Chizaram Igbomezie, Christopher Obermeyer, Tasha Vernon, Karin Hatzold, Heather Ingold, Michelle Rodolph, Sarah Yardly Jenkins   +23 more
doaj   +1 more source

A Synovium‐on‐Chip Platform to Study Multicellular Interactions in Arthritis

Advanced Healthcare Materials, EarlyView.
The Synovium‐on‐Chip comprises a thin microporous PDMS membrane to support co‐culture of fibroblast‐like synoviocytes (FLS), THP‐1‐derived macrophages, and endothelial cells, enabling real‐time analysis of synovial‐vascular interactions. FLS migration through the pores drives endothelial remodeling, while TNF‐α stimulation induces robust inflammatory ...
Laurens R. Spoelstra, Fleur R. Semmekrot, Nuno Araújo‐Gomes, Daniël Wijnperle, Monique M. A. Helsen, Martijn H.J. Van Den Bosch, Loes. I. Segerink, Séverine Le Gac, Marcel Karperien   +8 more
wiley   +1 more source

Bioavailability of a novel sustained‐release pellet formulation of 5‐flucytosine in healthy‐fed participants for use in patients with cryptococcal meningitis

Clinical and Translational Science
Cryptococcal meningoencephalitis (CM) is an opportunistic fungal infection and a major cause of death among people living with human immunodeficiency virus in sub‐Saharan Africa.
Nabila Ibnou Zekri Lassout, Vishal Goyal, Edrich Krantz, Francois Simon, Anouk Neven, Johanna Eriksson, Amaria Saayman, Vijay Satam, Carol Ruffell, Sarika Victor, Marylore Chenel, Aljosa Celebic, Henri Caplain, Jean‐Yves Gillon, Abhijit Deshmukh, Amit Antarkar, Eric Sjögren, Isabela Ribeiro   +17 more
doaj   +1 more source

Crisis translation: considering language needs in multilingual disaster settings [PDF]

, 2019
Purpose: The purpose of this conceptual paper is to highlight the role that language translation can play in disaster prevention and management and to make the case for increased attention to language translation in crisis communication.
Federici, Federico, O'Brien, Sharon
core   +1 more source

Diels‐Alder Click Chemistry as a Dynamic‐Covalent Crosslinking Method in Spheroid‐Encapsulating Hydrogels for Cartilage Engineering

Advanced Healthcare Materials, EarlyView.
This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...
Sanne M. van de Looij, Antonia G. Vasilopoulou, Lennard Spauwen, Antoinette van den Dikkenberg, Jasmijn V. Korpershoek, Mylene de Ruijter, Jos Malda, Bas G. P. van Ravensteijn, Tina Vermonden   +8 more
wiley   +1 more source

Impact of early initiation versus national standard of care of antiretroviral therapy in Swaziland's public sector health system : study protocol for a stepped-wedge randomized trial [PDF]

, 2017
Background: There is robust clinical evidence to support offering early access to antiretroviral treatment (ART) to all HIV-positive individuals, irrespective of disease stage, to both improve patient health outcomes and reduce HIV incidence. However, as
Barnighausen, Till, Delva, Wim, Fleming, Yvette, Khumalo, Gavin, Lejeune, Charlotte L, Mazibuko, Sikhathele, Mlambo, Charmaine Khudzie, Okello, Velephi, Reis, Ria, Spiegelman, Donna, Walsh, Fiona J, Zwane, Mandisa   +11 more
core   +5 more sources

Tunable Bioresorbable Scaffolds With Marine Sulfated Polysaccharides for Small‐Caliber Vascular Grafts: A Multi‐Layered Strategy Combining Electrospinning and 4‐Axis Printing

Advanced Healthcare Materials, EarlyView.
A multilayered small‐caliber vascular scaffold combining electrospinning and 4‐axis printing is developed and biofunctionalized with marine sulfated polysaccharides from Holothuria tubulosa. The resulting construct exhibits enhanced hemocompatibility, tunable mechanical properties, and supports endothelial and smooth muscle cell adhesion and ...
Gabriele Obino, Alberto Sensini, Tim ten Brink, Gabriele Nieddu, Tristan Bodet, Giovanni Andrea Deiana, Martijn van Griensven, Marilena Formato, Antonio J. Lepedda, Lorenzo Moroni   +9 more
wiley   +1 more source

The Global Risks Report 2016, 11th Edition [PDF]

, 2016
Now in its 11th edition, The Global Risks Report 2016 draws attention to ways that global risks could evolve and interact in the next decade. The year 2016 marks a forceful departure from past findings, as the risks about which the Report has been ...

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