Results 91 to 100 of about 37,169 (239)

Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation

BMC Cancer, 2019
Background Women have a lower risk of hepatocellular carcinoma (HCC) than men, and the decreased possibility of HCC in women is thought to depend on estrogen levels.
Sang R. Lee, Sun Woo Kwon, Young Ho Lee, Pelin Kaya, Jong Min Kim, Changhwan Ahn, Eui-Man Jung, Geun-Shik Lee, Beum-Soo An, Eui-Bae Jeung, Bae-keun Park, Eui-Ju Hong   +11 more
doaj   +1 more source

Tumor microenvironment responsive and nanozyme‐catalyzed photodynamic therapy via lysosome‐localized copper‐doped carbon dots

Responsive Materials, EarlyView.
The lysosome‐localized copper‐doped carbon dots (Cu‐MLCDs) leverage the high expression of glutathione (GSH)/H2O2 in the tumor microenvironment to achieve fluorescence reactivation enhancement. Through its multi‐nanozyme activities (glutathione peroxidase, peroxidase, and catalase), this nanoplatform relieves hypoxia, depletes GSH, and synergistically ...
Weixia Qin, Chengwei Hu, Haimei Zhu, Junjie Cui, Yaqing Cheng, Junfa Zhu, Qian Xu, Antonio Claudio Tedesco, Hong Bi   +8 more
wiley   +1 more source

Fabrication of genistein-loaded biodegradable TPGS-b-PCL nanoparticles for improved therapeutic effects in cervical cancer cells

, 2015
Hongling Zhang,1,2* Gan Liu,1,2* Xiaowei Zeng,1,2 Yanping Wu,1,2 Chengming Yang,3 Lin Mei,1,2 Zhongyuan Wang,2,4 Laiqiang Huang1,2 1School of Life Sciences, Tsinghua University, Beijing, People’s Republic of China; 2The Shenzhen Key Laboratory of ...
Mei L, Zhang H, Zeng X, Huang L, Yang C, Wang Z, Wu Y, Liu G   +7 more
core  

Genistein diet improves body weight, serum glucose and triglyceride levels in both male and female ob/ob mice

Diabetes, Metabolic Syndrome and Obesity, 2019
Schuyler Rockwood,1 Daniel Mason,1 Ryan Lord,1 Peter Lamar,2 Walter Prozialeck,2 Layla Al-Nakkash3 1Arizona College of Osteopathic Medicine, Midwestern University, Glendale, AZ, USA; 2Department of Pharmacology, College of Graduate Studies, Midwestern ...
Rockwood S, Mason D, Lord R, Lamar P, Prozialeck W, Al-Nakkash L   +5 more
doaj  

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

Effects of genistein on the endometrium: ultrasonographic evaluation

Gynecological Endocrinology, 2003
The aim of our study was to evaluate the effects of isoflavones on climacteric-related symptoms and on the endometrium in postmenopausal women, in a prospective, open, randomized, clinical trial performed at the Menopause Clinic of our Department.
Sammartino A, DI CARLO, COSTANTINO, Mandato VD, BIFULCO, GIUSEPPE, Di Stefano M, NAPPI, CARMINE   +5 more
openaire   +4 more sources

Kajian Pemanfaatan Genistein untuk Mencegah Gangguan Reproduksi Akibat Paparan Dioksin pada Mencit (Mus musculus L)

, 2013
Info lebih lanjut hub: Lembaga Penelitian Universitas Jember Jl. Kalimantan No.37 Jember telp. 0331-339385 Fax. 0331-337818Dari hasil penelitian dapat disimpulkan bahwa pemberian genistein terhadap struktur organ reproduksi (ovarium), irnplantasi ...
Eva Tyas Utami, Mahriani
core  

Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity

BMC Cancer, 2011
Background Soy consumption is associated with a lower incidence of colon cancer which is believed to be mediated by one of its of components, genistein.
Wasland Kaarin, Weber Christopher R, Qi Wentao, Savkovic Suzana D   +3 more
doaj   +1 more source

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source