Results 101 to 110 of about 37,195 (307)

Problems of methodology and explanation in word order universals research [PDF]

, 2010
Ever since the publication of Greenberg 1963, word order typologists have attempted to formulate and refine implicational universals of word order so as to characterize the restricted distribution of certain word order patterns, and in some cases have ...
LaPolla, Randy J.
core  

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Subject case alternation in Latvian and Estonian existential clauses

Eesti Rakenduslingvistika Ühingu Aastaraamat, 2019
In Latvian and Estonian existential clauses, the subject’s case form alternates between nominative vs. genitive (in Latvian) and nominative vs. partitive (in Estonian).
Andra Kalnača, Ilze Lokmane, Helena Metslang   +2 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Attribution vs. possession in Coptic : The origin and development of an opposition [PDF]

, 2009
This paper is intended to reconstruct the process that led to the formal opposition between the patterns used for expressing possessive and attributive relationships in the Coptic language (Sahidic dialect).
Egedi, Barbara
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Formal foundations for semantic theories of nominalisation [PDF]

, 2013
This paper develops the formal foundations of semantic theories dealing with various kinds of nominalisations. It introduces a combination of an event-calculus with a type-free theory which allows a compositional description to be given of such phenomena
Hamm, Fritz, Lambalgen, Michiel van
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Partitivity across domains

Catalan Journal of Linguistics
This introduction provides an overview of current research on partitivity. The contributions in this volume collectively address several persistent challenges in the analysis of partitivity, such as (i) the semantic underspecification of partitive ...
Anna Bartra Kaufmann, Cristina Real Puigdollers, Xavier Villalba Nicolás   +2 more
doaj   +1 more source