Results 91 to 100 of about 37,195 (307)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Universals in possessive morphology
Glossa, 2018 In this paper, we test the hypothesis that possessive pronouns have the same basic structure containing the genitive pronoun, plus, in some languages, some extra structure, as suggested by Caha (2009). In order to unravel the structure of these pronouns,
Jan Don, Yvonne Van Baal
doaj +2 more sources
Qualities, objects, sorts, and other treasures : gold digging in English and Arabic [PDF]
, 1999 In the present monograph, we will deal with questions of lexical typology in the nominal domain. By the term "lexical typology in the nominal domain", we refer to crosslinguistic regularities in the interaction between (a) those areas of the lexicon ...
Behrens, Leila, Sasse, Hans-Jürgen
core
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Academic Journal of Modern PhilologyIn this paper we will show the reasons why in late Latin and after in Romance languages the noun phrase introduced by the preposition de has taken the place of some uses of the ablative and the genitive. The preposition de signifies the starting point of
Marie-Dominique Joffre
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Romanian al and the syntax of case heads [PDF]
Bucharest Working Papers in Linguistics, 2014 After briefly presenting the distribution of the Romanian genitival agreeing particle al and the most important results of the previous research, I compare three recent analyses of al that are based on the idea that al is essentially a genitive marker ...
Ion Giurgea
doaj
C. C. Uhlenbeck on Indo-European, Uralic and Caucasian [PDF]
, 2010 In his early years, C. C. Uhlenbeck was particularly interested in the problem of the Indo-European homeland (1895, 1897). He rejected Herman Hirt’s theory (1892) that the words for ‘birch’, ‘willow’, ‘spruce’, ‘oak’, ‘beech’ and ‘eel’ point to Lithuania
Kortlandt, Frederik H. H.
core
Actas Dermo-Sifiliográficas (English Edition), 2008 Porokeratosis is a primary disorder of epidermal keratinization. The term covers several clinical variants that have in common the presence of a cornoid lamella in histological studies. Although porokeratotic lesions may appear anywhere on the skin, genital lesions are uncommon and may occur in cases of generalized porokeratosis with genital ...
openaire +2 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source