Results 81 to 90 of about 37,195 (307)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Possessive genitive in Portuguese: a cognitive-semantics analysis

Revista Linguística, 2019
The present study is dedicated to the analysis of the semantic structure and polysemy of the possessive genitive in Portuguese. Considering analyzes of possessive genitive in terms of conceptual metaphor (NIKIFORIDOU, 1991; LANGACKER, 1991) and ...
Jorge Luiz Ferreira Lisboa Júnior
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Kiekybės turinio kilmininkas A. Baranausko ir K. Brugmanno užrašytuose tarmių tekstuose

Baltistica, 2011
THE PARTITIVE GENITIVE OF QUANTITY IN 19th CENTURY DIALECT TEXTS COLLECTED BY A. BARANAUSKAS AND K. BRUGMANNSummaryAll the measure nouns found in the Eastern and Western High Lithuanian Kauniškiai dialect texts were divided into five subtypes.
Virginija Vasiliauskienė
doaj   +1 more source

'Bochanan modhail foghlaimte': Tiree Gaelic, lexicology and Glasgow's historical dictionary of Scottish Gaelic [PDF]

, 2008
The present paper is intended as a modest contribution towards the study of Tiree Gaelic, particularly its lexicon, drawing on a small part of the archives of the Historical Dictionary of Scottish Gaelic (HDSG) held in the Department of Celtic ...
Ó Maolalaigh, R.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The syntax of existential sentences in Serbian [PDF]

, 2008
Freeze (1992) argued on the basis of data from several different languages that there is a close relationship between existential sentences (stating the existence of an entity) and locative sentences (stating the location of an entity).
Hartmann, Jutta M., Milicevic, Nataša
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Jabetza-genitiboaren sintaxia eta erkatze anizkuna

Anuario del Seminario de Filología Vasca "Julio de Urquijo", 2009
After characterizing the so called possesive genitive as a case mark on nominal DP arguments, this article proposes that Basque structural genitive case is checked in the specifier of the head possessive, right below DP.
Xabier Artiagoitia
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source