Results 61 to 70 of about 1,983 (262)

Genesis of the Genitive of Negation in Balto-Slavic and Its Evidence in Contemporary Slovenian

open access: yesSlovenski Jezik - Slovene Linguistic Studies, 2019
Genitive of negation is a Balto-Slavic syntactic rule that governs the transformation of accusative complements of transitive verbs or subjects of existential constructions in positive sentences to genitive complements in negative sentences.
Žiga Pirnat
doaj  

Pięćdziesiąt lat minęło. O polskim dopełniaczu liczby pojedynczej raz jeszcze.

open access: yesAnnales Universitatis Paedagogicae Cracoviensis. Studia Linguistica, 2019
1968 saw the publication of Józefa Kobylińska’s monograph entitled Rozwój form dopełniacza liczby pojedynczej rzeczowników rodzaju męskiego w języku polskim [The development of the forms of the genitive singular of masculine nouns in the Polish language].
Krystyna Kleszczowa
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Der Müller Peter and (s) Fischers Emma

open access: yesNordisk Tidskrift för Socioonomastik
In German dialects and in rural communities, special personal names are used, in which the surname precedes the given name: der Müller Peter, Fischers Emma.
Theresa Schweden
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Two nouns in partitives: evidence from Japanese

open access: yesGlossa, 2017
We consider the proposal that partitives always contain two positions for nouns which may be filled by silent material from the perspective of Japanese.
Kazuko Yatsushiro, Uli Sauerland
doaj   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Das deutsche Gespenst verflüchtigt sich allmählich

open access: yesAkademisk Kvarter, 2012
Jan T. Schlosser and Sandra Tyra Helms Das deutsche Gespenst verflüchtigt sich allmählich Die Darstellung Deutschlands in Weekendavisen. (The German ghost gradually escapes The depiction of Germany in Weekendavisen).
Jan T. Schlosser, Sandra Tyra Helms
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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