Results 71 to 80 of about 1,979 (262)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

La rivalité dans une langue. L’exemple de la concurrence entre l’ablatif latin et le syntagme prépositionnel de +ablatif

open access: yesAcademic Journal of Modern Philology
In this paper we will show the reasons why in late Latin and after in Romance languages the noun phrase introduced by the preposition de has taken the place of some uses of the ablative and the genitive. The preposition de signifies the starting point of
Marie-Dominique Joffre
doaj   +1 more source

Jabetza-genitiboaren sintaxia eta erkatze anizkuna

open access: yesAnuario del Seminario de Filología Vasca "Julio de Urquijo", 2009
After characterizing the so called possesive genitive as a case mark on nominal DP arguments, this article proposes that Basque structural genitive case is checked in the specifier of the head possessive, right below DP.
Xabier Artiagoitia
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Universals in possessive morphology

open access: yesGlossa, 2018
In this paper, we test the hypothesis that possessive pronouns have the same basic structure containing the genitive pronoun, plus, in some languages, some extra structure, as suggested by Caha (2009). In order to unravel the structure of these pronouns,
Jan Don, Yvonne Van Baal
doaj   +2 more sources

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

Partitivity across domains

open access: yesCatalan Journal of Linguistics
This introduction provides an overview of current research on partitivity. The contributions in this volume collectively address several persistent challenges in the analysis of partitivity, such as (i) the semantic underspecification of partitive ...
Anna Bartra Kaufmann   +2 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

open access: yesFEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Genital Porokeratosis

open access: yesActas Dermo-Sifiliográficas (English Edition), 2008
Porokeratosis is a primary disorder of epidermal keratinization. The term covers several clinical variants that have in common the presence of a cornoid lamella in histological studies. Although porokeratotic lesions may appear anywhere on the skin, genital lesions are uncommon and may occur in cases of generalized porokeratosis with genital ...
openaire   +2 more sources

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