Results 81 to 90 of about 353,350 (233)

Why genes evolve faster on secondary chromosomes in bacteria [PDF]

, 2010
In bacterial genomes composed of more than one chromosome, one replicon is typically larger, harbors more essential genes than the others, and is considered primary.
Cooper, Vaughn S., Hatcher, Philip J., Vohr, Samuel H., Wrocklage, Sarah C.   +3 more
core   +1 more source

Cerulean: A hybrid assembly using high throughput short and long reads

, 2013
Genome assembly using high throughput data with short reads, arguably, remains an unresolvable task in repetitive genomes, since when the length of a repeat exceeds the read length, it becomes difficult to unambiguously connect the flanking regions.
D.R. Zerbino, E.W. Myers, E.W. Myers, F.J. Ribeiro, J. Schmutz, J.T. Simpson, J.T. Simpson, M. Eisenstein, M.J. Chaisson, M.J. Chaisson, P.A. Pevzner, R. Staden, R.M. Idury, S. Koren, T.D. Wu   +14 more
core   +1 more source

Genome sequences of 11 human vaginal Actinobacteria strains [PDF]

, 2016
The composition of the vaginal microbiota is an important health determinant. Several members of the phylum Actinobacteria have been implicated in bacterial vaginosis, a condition associated with many negative health outcomes. Here, we present 11 strains
Deitzler, Grace E, Hallsworth-Pepin, Kymberlie, Lewis, Amanda L, Lewis, Warren G, Mitreva, Makedonka, Park, SoEun, Robinson, Lloyd S, Ruiz, Maria J, Weimer, Cory, Wollam, Aye   +9 more
core   +2 more sources

Positional Homology in Bacterial Genomes [PDF]

Evolutionary Bioinformatics, 2006
In comparative genomic studies, syntenic groups of homologous sequence in the same order have been used as supplementary information that can be used in helping to determine the orthology of the compared sequences. The assumption is that orthologous gene copies are more likely to share the same genome positions and share the same gene neighbors.
Ingrid J. Burgetz, Salimah Shariff, Andy Pang, Elisabeth R. M. Tillier*   +3 more
openaire   +4 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Bacterial genome size and gene functional diversity negatively correlate with taxonomic diversity along a pH gradient

Nature Communications, 2023
Bacterial gene repertoires reflect adaptive strategies, contribute to ecosystem functioning and are limited by genome size. However, gene functional diversity does not necessarily correlate with taxonomic diversity because average genome size may vary by
Cong Wang, Qing-Yi Yu, Niu-Niu Ji, Yong Zheng, John W. Taylor, Liang-Dong Guo, Cheng Gao   +6 more
doaj   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Comparison of the DNBSEQ platform and Illumina HiSeq 2000 for bacterial genome assembly

Scientific Reports
The Illumina HiSeq platform has been a commonly used option for bacterial genome sequencing. Now the BGI DNA nanoball (DNB) nanoarrays platform may provide an alternative platform for sequencing of bacterial genomes.
Tongyuan Hu, Jianwei Chen, Xiaoqian Lin, Wenxin He, Hewei Liang, Mengmeng Wang, Wenxi Li, Zhinan Wu, Mo Han, Xin Jin, Karsten Kristiansen, Liang Xiao, Yuanqiang Zou   +12 more
doaj   +1 more source

Systematic determination of the mosaic structure of bacterial genomes: species backbone versus strain-specific loops

BMC Bioinformatics, 2005
Background Public databases now contain multitude of complete bacterial genomes, including several genomes of the same species. The available data offers new opportunities to address questions about bacterial genome evolution, a task that requires ...
Gendrault-Jacquemard A, Heuclin G, Sourivong F, Bourgait I, Chiapello H, Petit M-A, El Karoui M   +6 more
doaj   +1 more source

Bacteriophages and their structural organisation [PDF]

, 2012
Viruses are extremely small infectious particles that are not visible in a light microscope, and are able to pass through fine porcelain filters. They exist in a huge variety of forms and infect practically all living systems: animals, plants ...
Orlova, Elena
core   +2 more sources