Results 81 to 90 of about 2,805,364 (358)

Genome signatures, self-organizing maps and higher order phylogenies: a parametric analysis [PDF]

, 2007
Genome signatures are data vectors derived from the compositional statistics of DNA. The self-organizing map (SOM) is a neural network method for the conceptualisation of relationships within complex data, such as genome signatures.
Gatherer, Derek, Derek Gatherer
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Accurately assembling nanopore sequencing data of highly pathogenic bacteria

BMC Genomics
Background Bacterial genome exploration and outbreak analysis rely heavily on robust whole-genome sequencing and bioinformatics analysis. Widely-used genomic methods, such as genotyping and detection of genetic markers demand high sequencing accuracy and
Christine Thomas, Hanka Brangsch, Valentina Galeone, Martin Hölzer, Manja Marz, Jörg Linde   +5 more
doaj   +1 more source

TORMES: an automated pipeline for whole bacterial genome analysis

Bioinform., 2019
MOTIVATION The progress of High Throughput Sequencing (HTS) technologies and the reduction in the sequencing costs are such that Whole Genome Sequencing (WGS) could replace many traditional laboratory assays and procedures.
N. Quijada, D. Rodríguez-Lázaro, J. Eiros, M. Hernández   +3 more
semanticscholar   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

ALLPATHS: de novo assembly of whole-genome shotgun microreads

, 2008
New DNA sequencing technologies deliver data at dramatically lower costs but demand new analytical methods to take full advantage of the very short reads that they produce.
Kleber, M, Nusbaum, C, MacCallum, I, Jaffe, DB, Lander, ES, Shlyakhter, IA, Belmonte, MK, Butler, J   +7 more
core   +1 more source

Draft genome sequence of the Daphnia pathogen Octosporea bayeri: insights into the gene content of a large microsporidian genome and a model for host-parasite interactions [PDF]

, 2009
Background: The highly compacted 2.9-Mb genome of Encephalitozoon cuniculi placed the microsporidia in the spotlight, encoding a mere 2,000 proteins and a highly reduced suite of biochemical pathways.
Ebert, Dieter, Corradi, N., Pombert, J. F., Haag, Karen L., Keeling, P. J., Haag, Karen Luisa, Haag, K. L., Pombert, Jean-François, Corradi, Nicolas, Keeling, Patrick J., Keeling, Patrick J. (Patrick John), 1969-   +10 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The variability of the 16S rRNA gene in bacterial genomes and its consequences for bacterial community analyses.

PLoS ONE, 2013
16S ribosomal RNA currently represents the most important target of study in bacterial ecology. Its use for the description of bacterial diversity is, however, limited by the presence of variable copy numbers in bacterial genomes and sequence variation ...
Tomáš Větrovský, Petr Baldrian
doaj   +1 more source

Positional Homology in Bacterial Genomes [PDF]

Evolutionary Bioinformatics, 2006
In comparative genomic studies, syntenic groups of homologous sequence in the same order have been used as supplementary information that can be used in helping to determine the orthology of the compared sequences. The assumption is that orthologous gene copies are more likely to share the same genome positions and share the same gene neighbors.
Ingrid J. Burgetz, Salimah Shariff, Andy Pang, Elisabeth R. M. Tillier*   +3 more
openaire   +4 more sources