Results 31 to 40 of about 124,479 (257)

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

RELATe enables genome-scale engineering in fungal genomics [PDF]

Science Advances, 2020
Genomic DNA can be converted into sgRNA libraries for genome-wide screening of fungal factors in blood-brain barrier penetration.
Zhongming Li, Kwang Sik Kim
openaire   +2 more sources

MFPD: A Multiple Fungal Pathogen Detection Pipeline Across Diverse Habitats

Advanced Science, EarlyView.
The MFPD pipeline integrates a comprehensive ITS reference database of fungal pathogens, optimized parameters, and algorithms tailored for both full‐length and subregion sequences that balance accuracy and computational efficiency; it enables high‐throughput, species‐level identification from amplicon sequencing data, supporting large‐scale ...
Yi Shen, Xinrun Yang, Jiabao Yu, Yaozhong Zhang, Tianjie Yang, Yang Gao, Xiaofang Wang, Alexandre Jousset, Waseem Raza, Fang‐Jie Zhao, Qirong Shen, Gaofei Jiang, Zhong Wei, Yangchun Xu   +13 more
wiley   +1 more source

Widespread bacterial diversity within the bacteriome of fungi

Communications Biology, 2021
Robinson et al. explore bacterial associations in over 700 phylogenetically diverse fungal isolates with 16 S rRNA sequencing of fungal collections from across the globe and bioinformatic screening of publicly available fungal genome sequencing projects.
Aaron J. Robinson, Geoffrey L. House, Demosthenes P. Morales, Julia M. Kelliher, La Verne Gallegos-Graves, Erick S. LeBrun, Karen W. Davenport, Fabio Palmieri, Andrea Lohberger, Danaé Bregnard, Aislinn Estoppey, Matteo Buffi, Christophe Paul, Thomas Junier, Vincent Hervé, Guillaume Cailleau, Simone Lupini, Hang N. Nguyen, Amy O. Zheng, Luciana Jandelli Gimenes, Saskia Bindschedller, Debora F. Rodrigues, James H. Werner, Jamey D. Young, Pilar Junier, Patrick S. G. Chain   +25 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

AraR plays a more dominant role than XlnR in plant biomass conversion in Penicillium subrubescens

Current Research in Biotechnology
Penicillium subrubescens is a promising candidate for industrial applications as its plant cell wall-degrading enzyme production levels and saccharification abilities are similar to that of the well-established industrial species Aspergillus niger ...
Dujuan Liu, Li Xu, Mao Peng, Anna Lipzen, Vivian Ng, Emily Savage, Yu Zhang, Igor V. Grigoriev, Sandra Garrigues, Ronald P. de Vries   +9 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Multi‐Omics Analyses Reveal Divergent Molecular Mechanisms Underlying Plant Biomass Conversion by Five Fungi

MicrobiologyOpen
Fungal plant biomass conversion (FPBC) is of great importance to the global carbon cycle and has been increasingly applied for the production of biofuel and biochemicals from lignocellulose.
Mao Peng, Jiajia Li, Li Xu, Tania Chroumpi, Sandra Garrigues, Roland S. Kun, Jiali Meng, Maria Victoria Aguilar‐Pontes, Anna Lipzen, Vivian Ng, Chaevien S. Clendinen, Nikola Tolic, Scott E. Baker, Igor V. Grigoriev, Ronald P. deVries   +14 more
doaj   +1 more source

Transcriptional response of the white-rot fungus Dichomitus squalens to polysaccharides reveals a co-expression network of plant biomass conversion related genes

Current Research in Biotechnology
Wood-degrading white-rot fungi can efficiently degrade all plant biomass components, but the molecular mechanisms behind the degradation of plant polysaccharides remain poorly understood.
Victor M. Gonzalez Ramos, Astrid Mueller, Mao Peng, Megan Pawlowski, Anna Lipzen, Vivian Ng, Vasanth Singan, Mei Wang, Ronald P. de Vries, Igor V. Grigoriev, Joanna E. Kowalczyk, Miia R. Mäkelä   +11 more
doaj   +1 more source