Results 111 to 120 of about 10,877,278 (223)

Generation of Dual-Color FISH probes targeting 9p21, Xp21, and 17p13.1 loci as diagnostic markers for some genetic disorders and cancer in Egypt

Journal of Genetic Engineering and Biotechnology
Introduction: The fluorescence in situ hybridization (FISH) is a very important technique, as it can diagnose many genetic disorders and cancers. Molecular cytogenetic analysis (FISH) can diagnose numerical chromosome aberrations, sex chromosomes ...
Amal M. Mohamed, Maha Eid, Ola Eid, Shymaa H Hussein, Wael Mahmoud, Rana Mahrous, Khaled Refaat, Marwa Farid   +7 more
doaj  

Nucleotide repeats in mitochondrial genome determine human lifespan [PDF]

, 2008
Direct nucleotide repeats can facilitate deletions of segments of mitochondrial genome1, leading to a wide range of neuromuscular disorders1,2 as well as aging2,3 in humans.
Georgii Bazykin, Konstantin Popadin
core   +1 more source

Initial sequencing and analysis of the human genome

Nature, 2001
International Human Genome Sequencing Consortium
semanticscholar   +2 more sources

Tumor induction by disruption of the Dnmt1, PCNA and UHRF1 interactions. [PDF]

, 2008
The low level of DNA methylation in tumors compared to the level of DNA methylation in their normal-tissue counterparts or global DNA hypomethylation was one of the first epigenetic alterations to be found in human cancer^1,2^.
Audrey Geairon, Emilie Debien, Eric Hervouet, Francois Vallette, Helene Rogniaux, Lisenn Lalier, Mathilde Cheray, Pierre-Francois Cartron   +7 more
core   +1 more source

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

Nature Biotechnology, 2019
Daehwan Kim, Joseph M. Paggi, Chanhee Park, C. Bennett, S. Salzberg   +4 more
semanticscholar   +1 more source

Underlying Mathematics in Diversification of Human Olfactory Receptors in Different Loci [PDF]

, 2010
As per conservative estimate, approximately (51-105) Olfactory Receptors (ORs) loci are present in human genome occurring in clusters. These clusters are apparently unevenly spread as mosaics over 21 pair of human chromosomes.
Arunava Goswami, Pabitra Pal Choudhury, Sk. Sarif Hassan   +2 more
core   +1 more source

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

Cell, 2014
Suhas S. P. Rao, M. Huntley, Neva C. Durand, Elena K. Stamenova, Ivan D. Bochkov, James T. Robinson, Adrian L. Sanborn, Ido Machol, Arina D. Omer, E. Lander, Erez Lieberman Aiden   +10 more
semanticscholar   +1 more source

A Sequential Test Algorithm for DNA Pooling/ Bootstrap-Based Studies

Iatreia, 2010
DNA pooling is a practical way to reduce the cost of large-scale association studies to identify susceptibility loci. In contrast to individual genotyping, in DNA pooling we can combine samples from N cases and M controls into two single pooled sample ...
Jorge I. Vélez, Mauricio Arcos Burgos
doaj  

RNA-Guided Human Genome Engineering via Cas9

Science, 2013
P. Mali, Luhan Yang, K. Esvelt, John D Aach, M. Guell, James E. DiCarlo, J. Norville, G. Church   +7 more
semanticscholar   +1 more source

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Science, 2014
Ophir Shalem, Neville E. Sanjana, E. Hartenian, Xi Shi, David A. Scott, T. Mikkelsen, D. Heckl, B. Ebert, D. Root, John G Doench, Feng Zhang   +10 more
semanticscholar   +1 more source