Results 21 to 30 of about 11,509,666 (312)
npj Regenerative Medicine, 2021 Throughout their lifetime, fish maintain a high capacity for regenerating complex tissues after injury. We utilized a larval tail regeneration assay in the zebrafish Danio rerio, which serves as an ideal model of appendage regeneration due to its easy ...
Jason W. Sinclair +11 more
doaj +1 more source
Graph-Based Genome Alignment and Genotyping with HISAT2 and HISAT-genotype
Nature Biotechnology, 2019 The human reference genome represents only a small number of individuals, which limits its usefulness for genotyping. We present a method named HISAT2 (hierarchical indexing for spliced alignment of transcripts 2) that can align both DNA and RNA ...
Daehwan Kim +4 more
semanticscholar +1 more source
Biomédica: revista del Instituto Nacional de Salud, 2009 Introducción. Aunque la integración del virus linfotrópico humano tipo I no es al azar, se desconocen muchos de los detalles de este proceso. Objetivo. Evaluar las características de la cromatina celular adyacente a secuencias provirales en pacientes con
Mercedes Salcedo-Cifuentes +7 more
doaj +1 more source
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
Genome Biology, 2009 Bowtie is an ultrafast, memory-efficient alignment program for aligning short DNA sequence reads to large genomes. For the human genome, Burrows-Wheeler indexing allows Bowtie to align more than 25 million reads per CPU hour with a memory footprint of ...
Ben Langmead +3 more
semanticscholar +1 more source
Phenotypic variance explained by local ancestry in admixed African Americans
Frontiers in Genetics, 2015 We surveyed 26 quantitative traits and disease outcomes to understand the proportion of phenotypic variance explained by local ancestry in admixed African Americans. After inferring local ancestry as the number of African-ancestry chromosomes at hundreds
Daniel eShriner +6 more
doaj +1 more source
An Integrated Encyclopedia of DNA Elements in the Human Genome
Nature, 2012 The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor
ENCODEConsortium, Martin Renqiang Min
semanticscholar +1 more source
CADD: predicting the deleteriousness of variants throughout the human genome
Nucleic Acids Res., 2018 Combined Annotation-Dependent Depletion (CADD) is a widely used measure of variant deleteriousness that can effectively prioritize causal variants in genetic analyses, particularly highly penetrant contributors to severe Mendelian disorders.
Philipp Rentzsch +4 more
semanticscholar +1 more source
Initial sequencing and analysis of the human genome
Nature, 2001 The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human ...
E. Lander +255 more
semanticscholar +1 more source
Cell, 2014 Summary We use in situ Hi-C to probe the three-dimensional architecture of genomes, constructing haploid and diploid maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 billion contacts, achieving 1-kilobase resolution.
Suhas S. P. Rao +10 more
semanticscholar +1 more source
BMC Genomics, 2017 Background Characterization of genomic structural variation (SV) is essential to expanding the research and clinical applications of genome sequencing.
Oliver A. Hampton +10 more
doaj +1 more source