Results 21 to 30 of about 9,417,161 (263)

Pan-cancer analysis of mRNA stability for decoding tumour post-transcriptional programs

Communications Biology, 2022
The role of mRNA stability in shaping the cancer transcriptome is revealed using a statistical analysis of transcriptomic data.
Gabrielle Perron, Pouria Jandaghi, Elham Moslemi, Tamiko Nishimura, Maryam Rajaee, Rached Alkallas, Tianyuan Lu, Yasser Riazalhosseini, Hamed S. Najafabadi   +8 more
doaj   +1 more source

Genome sequencing of chimpanzee malaria parasites reveals possible pathways of adaptation to human hosts. [PDF]

, 2014
Plasmodium falciparum causes most human malaria deaths, having prehistorically evolved from parasites of African Great Apes. Here we explore the genomic basis of P.
Conway, David J, Conway, David J., Ollomo, Benjamin, Ollomo, B., Böhme, Ulrike, Berriman, Matthew, Thomas, A. W., Bohme, U., Rayner, Julian C., Otto, Thomas D, Rayner, Julian C, Otto, Thomas D., Spottiswoode, N., Newbold, C., Otto, T. D., Pain, A., Pain, Arnab, Thomas, Alan W., Rayner, J. C., Berriman, M., Sanders, M., Conway, D. J., Renaud, F., Sanders, Mandy, Quail, Michael, Renaud, François, Quail, M., Thomas, Alan W, Spottiswoode, Natasha, Newbold, Chris, Prugnolle, Franck   +30 more
core   +1 more source

Gender And The Human Genome

Mens Sana Monographs, 2009
GENDER ISSUES ARISE IN RELATION TO THE HUMAN GENOME ACROSS A NUMBER OF DIMENSIONS: the level of attention given to the nuclear genome as opposed to the mitochondrial; the level of basic scientific research; decision-making in the clinic related to both reproductive decision-making on the one hand, and diagnostic and predictive testing on the other; and
openaire   +4 more sources

The genomics of the human endometrium

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012
The endometrium is a complex tissue that lines the inside of the endometrial cavity. The gene expression of the different endometrial cell types is regulated by ovarian steroids and paracrine-secreted molecules from neighbouring cells. Due to this regulation, the endometrium goes through cyclic modifications which can be divided simply into the ...
Ruiz-Alonso, Maria, Blesa, David, Simón, Carlos   +2 more
openaire   +2 more sources

Cytogenomic characterization of 1q43q44 deletion associated with 4q32.1q35.2 duplication and phenotype correlation

Molecular Cytogenetics, 2018
Background Microdeletion of 1q43q44 causes a syndrome characterized by intellectual disability (ID), speech delay, seizures, microcephaly (MIC), corpus callosum abnormalities (CCA) and characteristic facial features.
A. M. Mohamed, H. T. El-Bassyouni, A. M. El-Gerzawy, S. A. Hammad, N. A. Helmy, A. K. Kamel, S. I. Ismail, M. Y. Issa, O. Eid, M. S. Zaki   +9 more
doaj   +1 more source

Community‐based recruitment and exome sequencing indicates high diagnostic yield in adults with intellectual disability

Molecular Genetics & Genomic Medicine, 2020
Background Establishing a genetic diagnosis for individuals with intellectual disability (ID) benefits patients and their families as it may inform the prognosis, lead to appropriate therapy, and facilitate access to medical and supportive services ...
Aniko Sabo, David Murdock, Shannon Dugan, Qingchang Meng, Marie‐Claude Gingras, Jianhong Hu, Donna Muzny, Richard Gibbs   +7 more
doaj   +1 more source

Leprosy and the Human Genome [PDF]

Microbiology and Molecular Biology Reviews, 2010
SUMMARYDespite the availability of effective treatment for several decades, leprosy remains an important medical problem in many regions of the world. Infection withMycobacterium lepraecan produce paucibacillary disease, characterized by well-formed granulomas and a Th1 T-cell response, or multibacillary disease, characterized by poorly organized ...
Elizabeth A, Misch, William R, Berrington, James C, Vary, Thomas R, Hawn   +3 more
openaire   +2 more sources

Expression of concern for global biomedical research by the human genome organization (HUGO)

Human Genomics
Cuts to US science funding will stall advances in genomics affecting public health, rare disease and cancer diagnostics and therapeutics in the US and around the world.
Ada Hamosh, Fabiana Arzuaga, Karen B. Avraham, Zilfalil Bin Alwi, Anne Bowcock, Sir John Burn, Piero Carninci, Collet Dandara, Iscia Lopes-Cendes, Leon Mutesa, Partha P. Majumder, Juergen K.V. Reichardt, Joris A. Veltman   +12 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source