Results 41 to 50 of about 2,078,242 (303)
Origins of the Human Genome Project [PDF]
, 1994 Dr. Cook-Deegan recounts some of the scientific and political history leading to controversy about the proper mix of private and public roles in pursuing genome research and bringing its fruits to bear, e.g., in preventing and curing ...
Cook-Deegan, Robert Mullan
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The Human Genome Revealed [PDF]
Genome Research, 2001 Seeing the International Sequencing Consortium's draft of the human genome is highly satisfying. The way in which its 3 billion bases have been determined closely followed the course outlined more than a decade ago by the National Academy of Sciences (NAS) Committee on “Mapping and Sequencing the Human Genome.” Bruce Alberts, now the President of the ...
openaire +2 more sources
BioTechniques, 1996 The Applied Biosystems PRISMTM fluorescence-based genotyping system as well as the Invitrogen TA Cloning® vector system are influenced by the tendency of Taq DNA polymerase to add an adenine nucleotide to the 3′ end of PCR products after extension ...
V.L. Magnuson +8 more
doaj +1 more source
Molecular Genetics & Genomic Medicine, 2021 Background This study aimed to delineate the clinical phenotype of patients with 9p deletions, pinpoint the chromosomal breakpoints, and identify the critical region for trigonocephaly, which is a frequent finding in 9p terminal deletion.
Amal M. Mohamed +20 more
doaj +1 more source
REAPR: a universal tool for genome assembly evaluation. [PDF]
, 2013 Methods to reliably assess the accuracy of genome sequence data are lacking. Currently completeness is only described qualitatively and mis-assemblies are overlooked.
Berriman, Matthew +5 more
core +2 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
HERVs, transposons and human diseases : part I [PDF]
, 2012 Part 2 and part 3 of the article can be found through this link: https://www.um.edu.mt/library/oar//handle/123456789/13012 https://www.um.edu.mt/library/oar//handle/123456789/13132It has been found that the human genome is full of relic retroviral ...
Baldacchino, Sandra, Grech, Alfred
core +2 more sources
Progressive pulmonary fibrosis in a murine model of Hermansky-Pudlak syndrome
Respiratory Research, 2022 Background HPS-1 is a genetic type of Hermansky-Pudlak syndrome (HPS) with highly penetrant pulmonary fibrosis (HPSPF), a restrictive lung disease that is similar to idiopathic pulmonary fibrosis (IPF).
Shachar Abudi-Sinreich +13 more
doaj +1 more source