Results 51 to 60 of about 9,417,161 (263)

Changes in Human Genomics [PDF]

Human Genomics, 2011
I would like to welcome you to the second issue of Volume 5 and also to announce several changes to the Journal including new members of our Editorial Board, the introduction of a new section 'Research Highlights' and, crucially, the introduction of open-access papers.
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Genome-Wide Joint Meta-Analysis of SNP and SNP-by-Smoking Interaction Identifies Novel Loci for Pulmonary Function [PDF]

, 2012
Genome-wide association studies have identified numerous genetic loci for spirometic measures of pulmonary function, forced expiratory volume in one second (FEV1), and its ratio to forced vital capacity (FEV1/FVC).
Wenbo Tang (110161), Alisa K. Manning (110227), Heinrich, J (Joachim), Thomas Lumley (57337), Sood, A, R Graham Barr, Brusselle, Guy G., Loth, Daan W, Akshay Sood (71826), O'Connor, George T, Liu, YM, Stephen S. Rich (7634141), Harris, Tamara B, Fornage, Myriam, Alisa K. Manning (7634102), Stephanie J. London (62450), Josée Dupuis (28859), Probst-Hensch, Nicole, Chen, TH, Elliott, Paul, Eiriksdottir, Gudny, Zhai, G., Jason Z. Liu (7634093), Patricia A. Cassano (110298), Hugues Aschard (110171), Joachim Heinrich (60421), Guy G Brusselle, Couper, D. J., Gu, Xiangjun, Uitterlinden, Andre G., Smith, AV, Couper, DJ, Lenore J. Launer (110269), Matthias Wjst (56613), Myriam Fornage (45591), Kritchevsky, S. B., Postma, Dirkje S., Liu, Y, Mirel, D. B., Rurth J.F. Loos (7634099), H. Marike Boezen (7634168), Uitterlinden, André G, Hysi, Pirro G., R. Graham Barr (7634171), Timothy D. Spector (7634159), Glaeser, S, Loos, Ruth J F, Christer Janson, Burkart, Kristin Marie, Heinrich, Joachim, Eiriksdottir, G, Hysi, P., Boezen, H Marike, Zhai, GJ, Liu, Jason, Probst-Hensch, Nicole M, O Dale Williams, George T. O'Connor (110263), Jason Z. Liu (110210), Uitterlinden, AG, Hofman, A., Heckbert, Susan R, David P Strachan, Daan W. Loth (7634072), Louise V. Wain (7588511), Tamara B Harris, Smith, Albert V, Jarvis, Deborah, Imboden, M., Launer, Lenore J, Heckbert, Susan R., Hysi, PG, Morrison, A. C., Marciante, K. D., Rich, Stephen S., Hartikainen, Anna-Liisa, Mirel, Daniel B, Harris, Tamara, Liu, Jason Z, Jarvelin, Marjo-Riitta, Kari E. North (68131), Aldrich, Melinda C., Manning, A. K., Koch, B., Couper, David J., Timothy D Spector, Curjuric, I., Wilk, J. B., Eijgelsheim, Mark, North, Kari E, Louise V Wain, Rivadeneira, F, Williams, O. D., Homuth, G, Marciante, KD, Cassano, P. A., Joanna Smolonska (101730), Susan R. Heckbert (7634165), Strachan, David P., Henry Völzke (64286), Boezen, H. M., Marciante, Kristin D., Jerome I. Rotter (7634114), Ramasamy, A, Alisa K Manning, Lumley, T., Amanda Henry, Daniel B. Mirel (7634153), Mark Eijgelsheim (110185), Bernd Meibohm (110267), Manichaikul, A, Manichaikul, Ani, Amy R Bentley, Daan W Loth, Kristin D. Marciante (110230), Aldrich, Melinda, Zhao, Jing Hua, Hysi, Pirro, Kurt Lohman, Alanna C Morrison, Melinda C. Aldrich (110234), Meibohm, B, O'Connor, George, Imboden, Medea, Gharib, Sina A, Wilk, Jemma B., Gudny Eiriksdottir (8872), Obeidat, Ma’en, Marchini, J, Stricker, Bruno H. C., Kurt Lohman (110218), O. Dale Williams (110242), Stephen B. Kritchevsky (7240181), Alanna C. Morrison (110248), Lenore J Launer, Franceschini, N, Tamara B. Harris (7240184), O’Connor, George T., Probst-Hensch, NM, Maria Soler Artigas (7634069), Launer, Lenore J., Marchini, Jonathan, Dupuis, Josee, Hall, Ian, Loehr, Laura, Nicole M. Probst-Hensch (7634162), Fernando Rivadeneira, Rich, S. S., Sina A. Gharib (63265), Cathy C. Laurie (110245), Kristin D. Marciante (7634105), Hancock, D. B., Stricker, BHC, Tamara B. Harris (110195), Henry, A, Guangju Zhai (110167), Bonnie R. Joubert (110252), Ian P. Hall (7377620), Probst-Hensch, Nicole M., Rotter, Jerome I, Nicholas J Wareham, Vonk, Judith, Dana B. Hancock (110121), R. Graham Barr (109958), Franceschini, Nora, Hammond, Christopher J., Burkart, KM, Bruno H C Stricker, Rochat, Thierry, Rotter, Jerome, Tobin, Martin, Boezen, H. Marike, Loos, Ruth J. F., Artigas, M.S., Loth, Daan W., Josée Dupuis, Medea Imboden, Lohman, K, Hall, I. P., Deborah Jarvis, Wain, Louise V., Guy G. Brusselle (7634108), André G. Uitterlinden (7634138), Loos, RJF, Judith M. Vonk (7634135), George T O'Connor, McArdle, Wendy L., Laurie, Cathy C., Barr, R. Graham, Dupuis, J, Khaw, K. T., Koch, B, Hancock, Dana, Burkart, Kristin, Manning, Alisa K., Tobin, Martin D, Jemma B Wilk, Völzke, H, Paul Elliott, Rochat, T., Artigas, Maria Soler, Boezen, Hendrika, Homuth, G., Patricia A. Cassano (7634174), Stephanie J. London (7634180), Melinda C Aldrich, Gudnason, V, Albert V. Smith (7634078), Bentley, Amy, Pirro G. Hysi (110207), Smith, Albert, Gharib, SA, Rich, Stephen, Albert V Smith, Martin D Tobin, Marjo-Riitta Jarvelin (110290), Dana B. Hancock (7634066), Wareham, N. J., Guy G. Brusselle (110236), Wareham, NJ, Bruce M Psaty, Ani Manichaikul, Smith, Albert V., Anna-Liisa Hartikainen, Nicole M Probst-Hensch, Chen, T-H, Sood, A., Ruth J F Loos, Bentley, Amy R, Gu, X, Jarvelin, MR, Adaikalavan Ramasamy, Daniel B Mirel, Uitterlinden, A., Jing Hua Zhao, Bruno H. C. Stricker (110279), Burkart, Kristen M., Morrison, Alanna, Hall, IP, Psaty, B. M., Meibohm, Bernd, Couper, David, Homuth, Georg, Harris, TB, Heckbert, S. R., Laurie, CC, Chen, T. H., Kritchevsky, Stephen, Mirel, Daniel B., Christopher J Hammond, Akshay Sood, Xiangjun Gu, Daan W. Loth (110140), Wareham, Nicholas J., Obeidat, M, Smolonska, J, Marciante, Kristin, Laurie, C., Psaty, Bruce, Lumley, Thomas, Sven Gläser, André G. Uitterlinden (2213413), Hofman, Albert, Zhao, JH, Jerome I. Rotter (103729), Loehr, Laura R, Yongmei Liu, Myriam Fornage, Cassano, Patricia A, Hartikainen, A. L., Xiangjun Gu (73651), Stricker, Bruno HC, Zhao, J. H., Tang, W, Brusselle, GG, Tang, Wenbo, Voelzke, Henry, Stephen B Kritchevsky, Boezen, Marike, Dana B Hancock, Laurie, Cathy C, London, S. J., Vilmundur Gudnason (8873), Strachan, DP, Jonathan Marchini (21497), Patricia A Cassano, Elliott, P., Susan R. Heckbert (110293), Wjst, M, Martin D. Tobin (110311), Wareham, Nicholas, North, KE, Spector, TD, David J Couper, Chen, Ting-hsu, Rotter, JI, Ramasamy, A., Nicholas J. Wareham (110277), Wain, Louise, Marjo-Riitta Jarvelin, Spector, Timothy D, Ma'en Obeidat, Psaty, Bruce M., Launer, Lenore, Lohman, Kurt, Adaikalavan Ramasamy (4841), Ma'en Obeidat (110232), Hartikainen, A.L., Peter Kraft, Gudnason, V., Dirkje S Postma, Strachan, D. P., Henry Völzke, Tobin, MD, Loehr, L. R., Morrison, Alanna C, Wain, LV, Thierry Rochat, Mcardle, Wendy, Smolonska, Joanna, Stricker, Bruno, Dirkje S. Postma (101740), Manning, AK, Barr, RG, Kraft, Phillip, Vonk, JM, Henry, A., Soler, Artigas, Bentley, A. R., Obeidat, Ma'en, Launer, L. J., Timothy D. Spector (110281), Strachan, David P, Brusselle, Guy, Christopher J. Hammond (110274), Liu, JZ, Loth, D. W., Vonk, Judith M., Wendy L. McArdle (110155), Bernd Meibohm, Loehr, LR, Hammond, Christopher J, Spector, T. D., Marchini, J., Cisca Wijmenga, Vonk, Judith M, Ting-hsu Chen, Ting-Hsu Chen (7634111), Barr, R Graham, Ruth J. F. Loos (110224), Hofman, Bert, Brusselle, G. G., North, Kari, Aschard, H., Kraft, P., Stephen B. Kritchevsky (110259), Bonnie R Joubert, David J. Couper (110257), O'Connor, G. T., Heinrich, J., Ting-hsu Chen (110239), Judith M Vonk, Ramasamy, Adaikalavan, Psaty, Bruce M, Sven Gläser (110276), Nicholas J. Wareham (7584569), Wain, L. V., Boezen, M, Aldrich, MC, Hancock, DB, Heckbert, SR, Hammond, C. J., H Marike Boezen, Christopher J. Hammond (7252211), North, Kari E., Zhai, G, Jing Hua Zhao (73808), Lumley, T, Aldrich, M., Smolonska, J., Vonk, J. M., Khaw, KT, Hartikainen, AL, Lenore J. Launer (7305602), Beate Koch (110151), Stricker, B. H. C., Heckbert, Susan, Kay-Tee Khaw, Williams, O. Dale, Uitterlinden, André, Hancock, Dana B., Ian P. Hall (110307), Kraft, P, Khaw, K-T, Kritchevsky, SB, Nora Franceschini, Jemma B. Wilk (110164), Wareham, Nicholas J, Georg Homuth (110202), Tobin, M. D., Curjuric, Ivan, Amy R. Bentley (110243), Joubert, B. R., Rochat, T, Gharib, Sina, Franceschini, N., Vilmundur Gudnason, Mirel, Daniel, Guangju Zhai, Janson, Christer,, Artigas, MS, Laura R. Loehr (110214), Rivadeneira, Fernando, Rich, SS, Melinda C. Aldrich (6688181), Boezen, HM, Albert V. Smith (103644), Manning, Alisa K, Morrison, Alanna C., Janson, C, Wijmenga, C, Jarvelin, M-R, Bentley, AR, Obeidat, M., David J. Couper (7634132), Mark Eijgelsheim, Kristin M. Burkart (110174), Bentley, Amy R., Jing Hua Zhao (7634084), Kristin M. Burkart (7634087), Loth, DW, Jonathan Marchini, London, SJ, Judith M. Vonk (71591), Kristin D Marciante, Spector, Timothy, Rivandeneiro, Fernando, Ani Manichaikul (110134), Rotter, J. I., Völzke, Henry, Aschard, Hugues, O'Connor, GT, Heinrich, J, Martin D. Tobin (7581161), Fornage, M., Barr, R. G., Bruce M. Psaty (103721), Gu, XJ, Zhai, Guangju, Jarvelin, M. R., Marciante, Kristin D, Ivan Curjuric (110179), Eiriksdottir, G., Susan R Heckbert, Sina A Gharib, Spector, Timothy D., Gläser, Sven, Homuyth, Georg, Medea Imboden (110145), Thomas Lumley, Hysi, Pirro G, Probst-Hensch, N. M., Gu, X., Harris, Tamara B., London, Stephanie J, Henry, Amanda, Joubert, BR, Peter Kraft (15118), Bruce M. Psaty (7634144), Bruno H.C. Stricker (7634156), Jerome I Rotter, Strachan, David, Wjst, M., Cathy C. Laurie (7634123), Meibohm, B., Launer, LJ (Lenore), Gudnason, Vilmundur, Hugues Aschard, Loehr, Laura R., Jarvis, D, Uitterlinden, André; id_orcid, Loth, Daan, Mirel, DB, Khaw, Kay-Tee, Postma, Dirkje S, Hall, Ian P, Rivadeneira, F., Deborah Jarvis (59834), Liu, Yongmei, Nicole M. Probst-Hensch (110284), Wilk, JB, Ivan Curjuric, Karl E. North (7634150), Curjuric, I, Liu, Jason Z., Kristin M Burkart, David P. Strachan (7634177), Burkart, Kristin M, Soler Artigas, María, Joanna Smolonska, Williams, O Dale, Kraft, Peter, Gläser, S, Pirro G. Hysi (7634090), Liu, J. Z., Eijgelsheim, M., Morrison, AC, Smith, A. V., Kay-Tee Khaw (110271), Wijmenga, Cisca, Albert Hofman, Elliott, P, Wendy L. McArdle (7634075), London, Stephanie J., Fornage, M, Gharib, Sina A., André G Uitterlinden, Voelzke, H, Loos, R., María Soler Artigas (110124), Hammond, CJ, Postma, Dirkje, Joubert, Bonnie, O'Connor, George T., Laurie, Cathy, Chen, T.H., McArdle, Wendy L, Kritchevsky, Stephen B, Glaeser, Sven, Loos, RJ, Alanna C. Morrison (7634126), Aldrich, Melinda C, Brusselle, Guy G, Cisca Wijmenga (32954), Joubert, Bonnie R., Imboden, M, Jemma B. Wilk (7634081), Jarvis, D., Rich, Stephen S, Ian P Hall, Christer Janson (83414), Sood, Akshay, McArdle, WL, Harris, T. B., Hammond, Christopher, Amanda Henry (110129), Kari E North, Couper, David J, Psaty, BM, Wenbo Tang, London, Stephanie, McArdle, W., Cathy C Laurie, Hartikainen, A-L, Louise V. Wain (110260), Wjst, Matthias, Hancock, Dana B, Bonnie R. Joubert (7634129), Janson, C., Koch, Beate, David P. Strachan (110302), Loos, Ruth, Wijmenga, C., Cassano, PA, Pirro G Hysi, Joubert, Bonnie R, Stricker, Bruno H C, Stephanie J London, Eijgelsheim, M, Georg Homuth, H. Marike Boezen (101746), Dupuis, J., Manning, Alisa, Tang, W., Kritchevsky, Stephen B., George T. O'Connor (7634147), Manichaikul, A., Laura R Loehr, Amy R. Bentley (7634120), Hofman, A, Postma, D., Stephen S. Rich (110262), Albert Hofman (107303), Wijmenga, Cisca; id_orcid, Matthias Wjst, Stricker, BH, Gharib, S. A., Wilk, Jemma, Burkart, Kristin M., Burkart, K. M., Beate Koch, Launer, LJ, O. Dale Williams (7634117), Cassano, Patricia A., Daniel B. Mirel (110265), Joachim Heinrich, Tang, WB, Janson, Christer, Postma, DS, Stephen S Rich, North, K. E., Thierry Rochat (110261), Paul Elliott (27295), Laura R. Loehr (7634096), Hall, Ian P., Nora Franceschini (91434), Tobin, Martin D., Aschard, H, Wain, Louise V, Liu, Y., Rotter, Jerome I., Wendy L McArdle, Lohman, K., Gudny Eiriksdottir, Williams, OD, Jason Z Liu, Anna-Liisa Hartikainen (110272), Wilk, Jemma B, María Soler Artigas, Yongmei Liu (104713), Cassano, Patricia, Fernando Rivadeneira (61551), Loos, Ruth JF, London, S.J. (Stephanie), Rivadeneira Ramirez, F. (Fernando), Morrison, A.C. (Alanna), Heinrich, J. (Joachim), Bentley, A.R. (Amy), Cassano, P.A. (Patricia), Hall, I.P. (Ian), Smolonska, J. (Joanna), Rich, S.S. (Stephen), Harris, T.B. (Tamara), Khaw, K-T. (Kay-Tee), Tobin, M.D. (Martin), O'Connor, G.T. (George), Janson, C. (Christer), Franceschini, N. (Nora), Laurie, C.C. (Cathy), Loehr, L.R. (Laura), Homuth, G. (Georg), Völzke, H. (Henry), Hancock, D.B. (Dana), Gläser, S. (Sven), Loos, R.J.F. (Ruth), Wareham, N.J. (Nick), Joubert, B.R. (Bonnie), Imboden, M. (Medea), Gudnason, V. (Vilmundur), Gharib, S.A. (Sina), Williams, O.D. (Dale), Uitterlinden, A.G. (André), Sood, A. (Akshay), Manichaikul, A. (Ani), Burkart, K.M. (Kristin), Wain, L.V. (Louise), Hammond, C.J. (Christopher), Brusselle, G.G. (Guy), McArdle, W.L. (Wendy), Psaty, B.M. (Bruce), Vonk, J.M. (Judith), Curjuric, I. (Ivan), Smith, A.V. (Davey), Marchini, J. (Jonathan), Aschard, H. (Hugues), Strachan, D.P. (David), Manning, A.K. (Alisa), Jarvis, D.L. (Deborah), Boezen, H.M. (Marike), Marciante, K. (Kristin), Dupuis, J. (Josée), Wjst, M. (Matthias), Zhai, G. (Guangju), Liu, Y. (YongMei), Rotter, J.I. (Jerome), Probst-Hensch, N.M. (Nicole M.), Rochat, T. (Thierry), Koch, B. (Beate), Heckbert, S.R. (Susan), North, K.E. (Kari), Wijmenga, C. (Cisca), Elliott, P. (Paul), Aldrich, M.C. (Melinda), Loth, D.W. (Daan), Stricker, B.H.Ch. (Bruno), Eiriksdottir, G. (Gudny), Jarvelin, M.-R. (Marjo-Riitta), Wilk, J.B. (Jemma), Tang, W. (Wenbo), Ramasamy, A. (Adaikalavan), Lohman, K. (Kurt), Mirel, D. (Daniel), Hysi, P.G. (Pirro), Spector, T.D. (Timothy), Henry, A. (Amanda), Hofman, A. (Albert), Kraft, P. (Peter), Zhao, J.H. (Jing Hua), Eijgelsheim, M. (Mark), Fornage, M. (Myriam), Liu, J. (Jason), Couper, D.J. (David), Gu, X. (Xiangjun), Lumley, T. (Thomas), Launer, L.J. (Lenore), Postma, D.S. (Dirkje), Barr, R.G. (Graham), Kritchevsky, S.B. (Stephen), Obeidat, M. (Ma'en), Meibohm, B. (Bernd), O'Connor, GT, Gläser, S., Völzke, H.   +712 more
core   +1 more source

Screening of the SHOX/PAR1 region using MLPA and miRNA expression profiling in a group of Egyptian children with non-syndromic short stature

Egyptian Journal of Medical Human Genetics, 2020
Background Short stature is defined as a body height below the third percentile, based on chronological age, or 2 standard deviations (SD) below the national height standard. The prevalence of short stature is around 2% of children worldwide.
Ola M. Eid, Maha M. Eid, Amany H. Abdelrahman, Rania M. A. Abdel kader, Marwa Farid, Rana Mahrous, Mona K. Mekkawy, Alaa K. Kamel, Inas Mazen, Hala T. El-Bassyouni   +9 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Copy number variation, chromosome rearrangement, and their association with recombination during avian evolution [PDF]

, 2010
Chromosomal rearrangements and copy number variants (CNVs) play key roles in genome evolution and genetic disease; however, the molecular mechanisms underlying these types of structural genomic variation are not fully understood.
Skinner, Benjamin M., Bunzey, Sydney K., Ellegren, Hans, Völker, Martin, Backström, Niclas, Langley, Elizabeth J, Griffin, Darren K., Skinner, Benjamin M, Bunzey, Sydney K, Griffin, Darren K, Ellegren, Hans,, Backström, Niclas,   +11 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Complete Genome Sequence of the Human Gut Symbiont Roseburia hominis [PDF]

, 2015
We report here the complete genome sequence of the human gut symbiont Roseburia hominis A2-183(T) (= DSM 16839(T) = NCIMB 14029(T)), isolated from human feces. The genome is represented by a 3,592,125-bp chromosome with 3,405 coding sequences.
Kelly, Denise, Travis, Anthony J, Aminov, Rustam, Travis, Anthony J., Aminov, Rustam I, Flint, Harry J   +5 more
core   +1 more source

Merqury: reference-free quality, completeness, and phasing assessment for genome assemblies

Genome Biology, 2020
Recent long-read assemblies often exceed the quality and completeness of available reference genomes, making validation challenging. Here we present Merqury, a novel tool for reference-free assembly evaluation based on efficient k-mer set operations.
Arang Rhie, Brian P. Walenz, Sergey Koren, Adam M. Phillippy   +3 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source