Results 71 to 80 of about 9,417,161 (263)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Fluorescence in situ hybridization to chromosomes as a tool to understand human and primate genome evolution [PDF]

, 2005
For the last 15 years molecular cytogenetic techniques have been extensively used to study primate evolution. Molecular probes were helpful to distinguish mammalian chromosomes and chromosome segments on the basis of their DNA content rather than solely ...
Wienberg, Johannes, Wienberg, J.
core   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

The Human Genome Prodject

, 1999
sic; Project.
Zimmern, Ron
core  

A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control [PDF]

, 2013
HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 ...
López-Galíndez, Cecilio, Gunthard, HF, Martinez-Picado, Javier, Guenthard, Huldrych F., Listgarten, J., Müller, Viktor, David Heckerman, Brumme, Chanson J., Klimkait, T, Haas, DW, Vernazza, P., Allen, Todd M, Allen, Todd M., Kutalik, Z, Casado, Concepción, Brumme, C. J., Harrigan, P. R., Rauch, A, John, M., Andri Rauch, Brumme, Zabrina L, McLaren, P. J., Listgarten, J, Fellay, Jacques, Paul J McLaren, Pfeifer, N., Allen, TM, Bartha, I, Telenti, A., Carlson, JM, Yerly, S., Javier Martinez-Picado, Viktor Müller, Todd M Allen, Mueller, Viktor, Günthard, Huldrych F, Enos Bernasconi, Carlson, J.M., Carlson, Jonathan M., McLaren, Paul J, Casado, C., Bartha, I., Heckerman, D., Listgarten, Jennifer, Lopez-Galindez, Luis Cecilio, Bernasconi, E, Thomas Klimkait, Fellay, J., Fellay, J, Harrigan, P. Richard, David W Haas, Bernasconi, Enos, Haas, David W., Telenti, A, Carlson, J. M., Gunthard, H. F., Nico Pfeifer, Stephen J O’Brien, Klimkait, T., Mina John, O'Brien, Stephen J, Yerly, S, Yerly, Sabine, Brumme, Z.L., John, Mina, Brumme, Z. L., Brumme, CJ, Allen, Todd, O'Brien, Stephen J., O'Brien, S. J., McLaren, PJ, Müller, V, Harrigan, P.R., Lopez-Galindez, C., O\u27Brien, Stephen J., Kutalik, Z., Christoph Lippert, Fusi, N, Allen, T.M., O’Brien, Stephen J, Jacques Fellay, Brumme, Zabrina L., Telenti, Amalio, Klimkait, Thomas, Dalmau, J, Dalmau, J., Harrigan, PR, Haas, D.W., John, M, Lopez-Galindez, C, Martinez-Picado, J., Muller, V., Yerly Ferrillo, Sabine, Harrigan, P Richard, Jonathan M Carlson, Brumme, ZL, Zoltán Kutalik, Bernasconi, E., O'Brien, S.J., Chanson J Brumme, Carlson, Jonathan M, Brumme, C.J., Brumme, Chanson J, Vernazza, P, Amalio Telenti, Cecilio López-Galíndez, Lippert, Christoph, Nicolo Fusi, Kutalik, Zoltán, Judith Dalmau, Pietro Vernazza, Lippert, C, Rauch, A., Allen, T. M., P Richard Harrigan, István Bartha, Heckerman, David, Gunthard, Huldrych F., Zabrina L Brumme, Lippert, C., Pfeifer, Nico, McLaren, Paul J., McLaren, P.J., Sabine Yerly, Rauch, Andri, Bartha, István, O'Brien, SJ, Günthard, H.F., Pfeifer, N, Fusi, Nicolo, Concepción Casado, Heckerman, D, Haas, D. W., Vernazza, Pietro, Martinez-Picado, J, Dalmau, Judith, Haas, David W, Casado, C, Huldrych F Günthard, Jennifer Listgarten, Fusi, N., John M, Vernazza P, O'Brien SJ, Haas DW, Bartha I, Telenti A, Allen TM, Bernasconi E, Fellay J, Martinez-Picado J, Fusi N, Günthard HF, Klimkait T, Listgarten J, Yerly S, Harrigan PR, Rauch A, Brumme CJ, Dalmau J, Kutalik Z, Lippert C, McLaren PJ, Carlson JM, Casado C, Brumme ZL, Heckerman D, López-Galíndez C, Pfeifer N, Müller V   +169 more
core   +3 more sources

The GENESTAR manual for biospecimen collection biobanking and omics data generation from commercial space missions

npj Microgravity
The surge in commercial and civilian spaceflight enables the systematic and longitudinal, large-scale biospecimen collection to understand the prospective effects of space travel on human health.
Aparna Krishnavajhala, Marie-Claude Gingras, Emmanuel Urquieta, Hsu Chao, Dilrukshi Bandaranaike, Yi Chen, Sravya Bhamidipati, Viktoriya Korchina, S. Michelle Griffin, Michal M. Masternak, Hannah Moreno, Javid Mohammed, Mullai Murugan, Jennifer E. Posey, Jimmy H. Wu, Donna Muzny, Richard A. Gibbs, Harsha Doddapaneni   +17 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Robert Cook-Deegan Human Genome Archive Box Listing - Set 2

, 2014
The Robert Cook-Deegan Human Genome Archive is founded on the bibliography of The Gene Wars: Science, Politics, and the Human Genome. The archive encompasses both physical and digital materials related to The Human Genome Project (HGP) and includes ...

core  

Regional regulation of transcription in the chicken genome [PDF]

, 2010
Background Over the past years, the relationship between gene transcription and chromosomal location has been studied in a number of different vertebrate genomes. Regional differences in gene expression have been found in several different species.
Nie, H., Crooijmans, R.P.M.A., Groenen, M.A.M., Bastiaansen, J.W.M., Megens, H.J.W.C., Richard PMA Crooijmans, Martien AM Groenen, Haisheng Nie, John WM Bastiaansen, Hendrik-Jan Megens   +9 more
core   +1 more source