Results 71 to 80 of about 11,509,666 (312)
Accurate Whole Human Genome Sequencing using Reversible Terminator Chemistry
Nature, 2008 DNA sequence information underpins genetic research, enabling discoveries of important biological or medical benefit. Sequencing projects have traditionally used long (400–800 base pair) reads, but the existence of reference sequences for the human and ...D. Bentley, S. Balasubramanian, H. Swerdlow, G. P. Smith, J. Milton, Clive Brown, K. Hall, D. Evers, Colin L. Barnes, Helen Bignell, J. M. Boutell, J. Bryant, Richard J. Carter, R. K. Cheetham, A. Cox, D. Ellis, Michael R. Flatbush, N. Gormley, S. Humphray, L. Irving, Mirian Karbelashvili, Scott M. Kirk, Heng Li, Xiaohai Liu, K. Maisinger, L. Murray, B. Obradovic, T. Ost, M. Parkinson, Mark Pratt, I. Rasolonjatovo, M. Reed, R. Rigatti, C. Rodighiero, M. Ross, A. Sabot, S. Sankar, A. Scally, G. Schroth, Mark E. B. Smith, V. P. Smith, A. Spiridou, Peta E. Torrance, Svilen Tzonev, Eric H. Vermaas, Klaudia Walter, Xiaolin Wu, Lu Zhang, Mohammed D. Alam, C. Anastasi, I. Aniebo, D. M. Bailey, Iain Bancarz, Saibal Banerjee, Selena Barbour, P. Baybayan, Vincent Benoit, Kevin Benson, Claire Bevis, Phillip J. Black, A. Boodhun, Joe Brennan, J. Bridgham, Rob C. Brown, A. Brown, Dale H. Buermann, Abass A. Bundu, James C. Burrows, N. Carter, Nestor Castillo, M. C. E. Catenazzi, Simon Chang, R. Cooley, Natasha R. Crake, Olubunmi O. Dada, Konstantinos D. Diakoumakos, Belen Dominguez-Fernandez, D. Earnshaw, Ugonna C. Egbujor, Dave Elmore, S. Etchin, Mark Ewan, M. Fedurco, Louise J. Fraser, K. F. Fajardo, W. S. Furey, Dave George, Kimberley J. Gietzen, Colin P. Goddard, G. Golda, Philip A. Granieri, David E. Green, D. Gustafson, Nancy F. Hansen, K. Harnish, C. Haudenschild, Narinder I. Heyer, Matthew M. Hims, Johnny T. Ho, Adrian Horgan, Katya Hoschler, Steven Hurwitz, D. V. Ivanov, Maria Q. Johnson, Terena James, T. A. Jones, Gyoung-Dong Kang, T. Kerelska, A. Kersey, I. Khrebtukova, A. Kindwall, Z. Kingsbury, P. Kokko-Gonzales, Anil Kumar, M. Laurent, C. Lawley, Sarah E. Lee, X. Lee, A. Liao, Jennifer A. Loch, Mitch Lok, Shujun J Luo, Radhika M. Mammen, J. W. Martin, P. McCauley, P. McNitt, Parul Mehta, Keith Moon, Joe W. Mullens, T. Newington, Zemin Ning, B. Ng, Sonia M. Novo, Michael J. O'neill, M. Osborne, A. Osnowski, Omead Ostadan, L. Paraschos, L. Pickering, Andrew C. Pike, A. Pike, D. Chris Pinkard, Daniel P. Pliskin, Joe Podhasky, Victor J. Quijano, C. Raczy, V. Rae, S. Rawlings, Ana Chiva Rodriguez, Phyllida Roe, J. Rogers, M. C. Rogert Bacigalupo, Nikolai Romanov, A. Romieu, Rithy K. Roth, Natalie J. Rourke, Silke T. Ruediger, E. Rusman, Raquel M. Sanches-Kuiper, M. Schenker, J. Seoane, Richard Shaw, Mitch Shiver, S. Short, N. Sizto, Johannes P. Sluis, M. A. Smith, J. S. Sohna, Eric Spence, K. Stevens, Neil Sutton, L. Szajkowski, C. Tregidgo, G. Turcatti, S. Vandevondele, Yuli Verhovsky, S. Virk, S. Wakelin, Gregory Walcott, Jingwen Wang, G. Worsley, Juying Yan, L. Yau, Mike Zuerlein, J. Rogers, J. Mullikin, M. Hurles, N. J. McCooke, John S. West, F. Oaks, Peter L. Lundberg, D. Klenerman, R. Durbin, Anthony J. Smith +193 moresemanticscholar +1 more sourceHyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky +11 morewiley +1 more sourceThe Human Genome: An Introduction [PDF]
The Oncologist, 2001 The Oncologist 2001;6:100-109 www.TheOncologist.com Correspondence: Jeroen Aerssens, Ph.D., Department of Pharmacogenomics, Janssen Research Foundation, Turnhoutseweg 30, Beerse B-2340, Belgium. Telephone: 32-14-606146; Fax: 32-14-607162; e-mail: jaerssen@janbe.jnj.com Received September 29, 2000; accepted for publication November 28, 2000.J, Aerssens, M, Armstrong, R, Gilissen, N, Cohen +3 moreopenaire +2 more sourcesGeneration of Dual-Color FISH probes targeting 9p21, Xp21, and 17p13.1 loci as diagnostic markers for some genetic disorders and cancer in Egypt
Journal of Genetic Engineering and BiotechnologyIntroduction: The fluorescence in situ hybridization (FISH) is a very important technique, as it can diagnose many genetic disorders and cancers. Molecular cytogenetic analysis (FISH) can diagnose numerical chromosome aberrations, sex chromosomes ...Amal M. Mohamed, Maha Eid, Ola Eid, Shymaa H Hussein, Wael Mahmoud, Rana Mahrous, Khaled Refaat, Marwa Farid +7 moredoaj +1 more sourceBoostMe accurately predicts DNA methylation values in whole-genome bisulfite sequencing of multiple human tissues
BMC Genomics, 2018 Background Bisulfite sequencing is widely employed to study the role of DNA methylation in disease; however, the data suffer from biases due to coverage depth variability.Luli S. Zou, Michael R. Erdos, D. Leland Taylor, Peter S. Chines, Arushi Varshney, The McDonnell Genome Institute, Stephen C. J. Parker, Francis S. Collins, John P. Didion +8 moredoaj +1 more sourceScreening of the SHOX/PAR1 region using MLPA and miRNA expression profiling in a group of Egyptian children with non-syndromic short stature
Egyptian Journal of Medical Human Genetics, 2020 Background Short stature is defined as a body height below the third percentile, based on chronological age, or 2 standard deviations (SD) below the national height standard. The prevalence of short stature is around 2% of children worldwide.Ola M. Eid, Maha M. Eid, Amany H. Abdelrahman, Rania M. A. Abdel kader, Marwa Farid, Rana Mahrous, Mona K. Mekkawy, Alaa K. Kamel, Inas Mazen, Hala T. El-Bassyouni +9 moredoaj +1 more sourceProgressive pulmonary fibrosis in a murine model of Hermansky-Pudlak syndrome
Respiratory Research, 2022 Background HPS-1 is a genetic type of Hermansky-Pudlak syndrome (HPS) with highly penetrant pulmonary fibrosis (HPSPF), a restrictive lung disease that is similar to idiopathic pulmonary fibrosis (IPF).Shachar Abudi-Sinreich, Steven P. Bodine, Tadafumi Yokoyama, Nathanial J. Tolman, Michal Tyrlik, Lauren C. Testa, Chen G. Han, Heidi M. Dorward, Stephen M. Wincovitch, Yair Anikster, William A. Gahl, Resat Cinar, Bernadette R. Gochuico, May Christine V. Malicdan +13 moredoaj +1 more sourcePre-sequencing assessment of RNA-Seq library quality using real-time qPCR
BioTechniquesRNA sequencing (RNA-Seq) is an essential assay for studying transcriptome profiling. Ribosomal RNA (rRNA) comprises more than 80–90% of total cellular RNA; efficient removal is essential for accurately capturing transcriptomes, particularly to sequence ...Kavya Kottapalli, Hsu Chao, Qi Jiang, Jimmonique Donelson, Nathanael Emerick, Sravya V Bhamidipati, Zeineen Momin, Tittu Mathew, Ziad M. Khan, Viktoriya Korchina, Marie-Claude Gingras, Donna Muzny, Richard Gibbs, Harsha Doddapaneni +13 moredoaj +1 more sourceBiophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the Inbar Yosibash, Raya Sorkinwiley +1 more source
