Results 81 to 90 of about 8,105,978 (263)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

P035: Estimating the carrier frequency and prevalence of inborn errors of propionate and cobalamin metabolism using population databases

Genetics in Medicine Open, 2023
Jennifer Sloan, Irini Manoli, Charles Venditti   +2 more
doaj   +1 more source

Hermansky-Pudlak syndrome and oculocutaneous albinism in Chinese children with pigmentation defects and easy bruising

Orphanet Journal of Rare Diseases, 2019
Background Determining the etiology of oculocutaneous albinism is important for proper clinical management and to determine prognosis. The purpose of this study was to genotype and phenotype eight adopted Chinese children who presented with ...
Bradley Power, Carlos R. Ferreira, Dong Chen, Wadih M. Zein, Kevin J. O’Brien, Wendy J. Introne, Joshi Stephen, William A. Gahl, Marjan Huizing, May Christine V. Malicdan, David R. Adams, Bernadette R. Gochuico   +11 more
doaj   +1 more source

Human genome news /

, 1990
Latest issue consulted: Vol. 8, no. 3 and 4 (Jan.-June 1997).Distributed to depository libraries in microfiche.Title from caption.Some v. issued in combined form.Mode of access: Internet.Prepared May 1990, at the request of DOE Office of Health and ...
National Center for Human Genome Research (U.S.), United States. Dept. of Energy. Office of Health and Environmental Research., Oak Ridge National Laboratory. Health Sciences Research Division. Biomedical and Environmental Information Analysis Section., Oak Ridge National Laboratory. Health and Safety Research Division. Biomedical and Environmental Information Analysis Section.   +3 more
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells

Epigenetics & Chromatin, 2019
Background The MAPK/ERK signaling pathway is an essential regulator of numerous cell processes that are crucial for normal development as well as cancer progression.
Temesgen D. Fufa, Laura L. Baxter, Julia C. Wedel, Derek E. Gildea, NISC Comparative Sequencing Program, Stacie K. Loftus, William J. Pavan   +6 more
doaj   +1 more source

Entrepreneurial Experiments in Science Policy: Analizing the Human Genome Project [PDF]

We re-conceptualize the role of science policy makers, envisioning and illustrating their move from being simple investors in scientific projects to entrepreneurs who create the conditions for entrepreneurial experiments and initiate them.
Fiona E. Murray, Kenneth G. Huang
core  

Inactive or moderately active human promoters are enriched for inter-individual epialleles. [PDF]

, 2013
BACKGROUND: Inter-individual epigenetic variation, due to genetic, environmental or random influences, is observed in many eukaryotic species. In mammals, however, the molecular nature of epiallelic variation has been poorly defined, partly due to the ...
Gavin Giovannoni, Hurd, PJ, Ramagopalan, SV, Paul J Hurd, R David Leslie, Holland, ML, Mohammed I Hawa, George C Ebers, Leslie, RD, Sreeram V Ramagopalan, Down, TA, Ebers, GC, Huriya Beyan, Vardhman K Rakyan, Beyan, H, Gemma, C, Ebers, George, Carolina Gemma, Giovannoni, G, Michelle L Holland, Hawa, MI, Thomas A Down, Rakyan, VK   +22 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Novel variant in WT1 gene associated with MGD and unique kidney disease phenotype

Journal of Rare Diseases
Introduction Wilms tumor 1 (WT1)-related disorders are a group of hereditary disorders caused by alterations in the WT1 gene. WT1 expression is critical for the maturation of many organs, such as the gonads, kidneys, and spleen.
Heba A. Hassan, Inas Mazen, Mona K. Mekkawy, Aya Elaidy, Alaa Kamel, Mona L. Essawi   +5 more
doaj   +1 more source