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Ethics of modifying the mitochondrial genome [PDF]
Journal of Medical Ethics, 2010 Recent preclinical studies have shown the feasibility of specific variants of nuclear transfer to prevent mitochondrial DNA disorders. Nuclear transfer could be a valuable reproductive option for carriers of mitochondrial mutations.
Bredenoord, A L +3 more
core +7 more sources
The first complete mitochondrial genome assembly and comparative analysis of the fern Blechnaceae family: Blechnopsis orientalis [PDF]
Frontiers in Plant ScienceIntroductionBlechnopsis orientalis (L.) C. Presl is a medicinal and edible fern species belonging to the Blechnaceae family. Currently, the complete mitochondrial genome of B. orientalis, as well as those of other Blechnaceae species, remains unreported,
Yutong Huang +9 more
doaj +2 more sources
Complete mitochondrial genome of the Verticillium-wilt causing plant pathogen Verticillium nonalfalfae [PDF]
, 2016 Verticillium nonalfalfae is a fungal plant pathogen that causes wilt disease by colonizing the vascular tissues of host plants. The disease induced by hop isolates of V. nonalfalfae manifests in two different forms, ranging from mild symptoms to complete
de Jonge, Ronnie +4 more
core +23 more sources
Structural characteristics of the melon mitochondria genome
Vegetable Research, 2022 The mitochondrial genome can provide important genetic information of melon. We reported the mitochondrial genome sequence of melon in a previous study, the structural characteristics of the melon mitochondrial genome were further analyzed in the present
Haonan Cui +3 more
doaj +1 more source
The Insights into Mitochondrial Genomes of Sunflowers [PDF]
Plants, 2021 The significant difference in the mtDNA size and structure with simultaneous slow evolving genes makes the mitochondrial genome paradoxical among all three DNA carriers in the plant cell. Such features make mitochondrial genome investigations of particular interest.
Maksim S. Makarenko +3 more
openaire +4 more sources
Modifying the Mitochondrial Genome [PDF]
Cell Metabolism, 2016 Human mitochondria produce ATP and metabolites to support development and maintain cellular homeostasis. Mitochondria harbor multiple copies of a maternally inherited, non-nuclear genome (mtDNA) that encodes for 13 subunit proteins of the respiratory chain.
Patananan, Alexander N +3 more
openaire +5 more sources
The ageing mitochondrial genome [PDF]
Nucleic Acids Research, 2007 The population of elderly individuals has increased significantly over the past century and is predicted to rise even more rapidly in the future. Ageing is a major risk factor for many diseases such as neurodegenerative disease, diabetes and cancer. This highlights the importance of understanding the mechanisms involved in the ageing process.
Kim J. Krishnan +3 more
openaire +2 more sources
Treatable inherited metabolic disorders causing intellectual disability: 2021 review and digital app
Orphanet Journal of Rare Diseases, 2021 Background The Treatable ID App was created in 2012 as digital tool to improve early recognition and intervention for treatable inherited metabolic disorders (IMDs) presenting with global developmental delay and intellectual disability (collectively ...
Eva M. M. Hoytema van Konijnenburg +7 more
doaj +1 more source
Lophotrochozoan mitochondrial genomes [PDF]
Integrative and Comparative Biology, 2006 Progress in both molecular techniques and phylogenetic methods has challenged many of the interpretations of traditional taxonomy. One example is in the recognition of the animal superphylum Lophotrochozoa (annelids, mollusks, echiurans, platyhelminthes, brachiopods, and other phyla), although the relationships within this group and the inclusion of ...
Valles, Yvonne, Boore, Jeffrey L.
openaire +3 more sources
Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging
Genome Biology, 2020 Background Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease.
Scott A. Lujan +12 more
doaj +1 more source