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The first complete mitochondrial genome assembly and comparative analysis of the fern Blechnaceae family: Blechnopsis orientalis [PDF]
Frontiers in Plant ScienceIntroductionBlechnopsis orientalis (L.) C. Presl is a medicinal and edible fern species belonging to the Blechnaceae family. Currently, the complete mitochondrial genome of B. orientalis, as well as those of other Blechnaceae species, remains unreported,
Yutong Huang +9 more
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Experiences from dual genome next-generation sequencing panel testing for mitochondrial disorders: a comprehensive molecular diagnosis [PDF]
Frontiers in GeneticsIntroductionThe molecular diagnosis of mitochondrial disorders is complicated by phenotypic variability, genetic heterogeneity, and the complexity of mitochondrial heteroplasmy.
Elizabeth Gorman +18 more
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Structural characteristics of the melon mitochondria genome
Vegetable Research, 2022 The mitochondrial genome can provide important genetic information of melon. We reported the mitochondrial genome sequence of melon in a previous study, the structural characteristics of the melon mitochondrial genome were further analyzed in the present
Haonan Cui +3 more
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The Insights into Mitochondrial Genomes of Sunflowers [PDF]
Plants, 2021 The significant difference in the mtDNA size and structure with simultaneous slow evolving genes makes the mitochondrial genome paradoxical among all three DNA carriers in the plant cell. Such features make mitochondrial genome investigations of particular interest.
Maksim S. Makarenko +3 more
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Modifying the Mitochondrial Genome [PDF]
Cell Metabolism, 2016 Human mitochondria produce ATP and metabolites to support development and maintain cellular homeostasis. Mitochondria harbor multiple copies of a maternally inherited, non-nuclear genome (mtDNA) that encodes for 13 subunit proteins of the respiratory chain.
Patananan, Alexander N +3 more
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The ageing mitochondrial genome [PDF]
Nucleic Acids Research, 2007 The population of elderly individuals has increased significantly over the past century and is predicted to rise even more rapidly in the future. Ageing is a major risk factor for many diseases such as neurodegenerative disease, diabetes and cancer. This highlights the importance of understanding the mechanisms involved in the ageing process.
Kim J. Krishnan +3 more
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Treatable inherited metabolic disorders causing intellectual disability: 2021 review and digital app
Orphanet Journal of Rare Diseases, 2021 Background The Treatable ID App was created in 2012 as digital tool to improve early recognition and intervention for treatable inherited metabolic disorders (IMDs) presenting with global developmental delay and intellectual disability (collectively ...
Eva M. M. Hoytema van Konijnenburg +7 more
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Lophotrochozoan mitochondrial genomes [PDF]
Integrative and Comparative Biology, 2006 Progress in both molecular techniques and phylogenetic methods has challenged many of the interpretations of traditional taxonomy. One example is in the recognition of the animal superphylum Lophotrochozoa (annelids, mollusks, echiurans, platyhelminthes, brachiopods, and other phyla), although the relationships within this group and the inclusion of ...
Valles, Yvonne, Boore, Jeffrey L.
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Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging
Genome Biology, 2020 Background Acquired human mitochondrial genome (mtDNA) deletions are symptoms and drivers of focal mitochondrial respiratory deficiency, a pathological hallmark of aging and late-onset mitochondrial disease.
Scott A. Lujan +12 more
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EMBO Molecular Medicine, 2023 Topoisomerase 3α (TOP3A) is an enzyme that removes torsional strain and interlinks between DNA molecules. TOP3A localises to both the nucleus and mitochondria, with the two isoforms playing specialised roles in DNA recombination and replication ...
Direnis Erdinc +32 more
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