Results 91 to 100 of about 1,479,755 (314)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The mitochondrial brain: From mitochondrial genome to neurodegeneration

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2010
Mitochondrial DNA mutations are an important cause of neurological disease. The clinical presentation is very varied in terms of age of onset and different neurological signs and symptoms. The clinical course varies considerably but in many patients there is a progressive decline, and in some evidence of marked neurodegeneration.
Turnbull, H, Lax, N, Diodato, D, Ansorge, O, Turnbull, D   +4 more
openaire   +3 more sources

The mitochondrial genome of soybean reveals complex genome structures and gene evolution at intercellular and phylogenetic levels. [PDF]

PLoS ONE, 2013
Determining mitochondrial genomes is important for elucidating vital activities of seed plants. Mitochondrial genomes are specific to each plant species because of their variable size, complex structures and patterns of gene losses and gains during ...
Shengxin Chang, Yankun Wang, Jiangjie Lu, Junyi Gai, Jijie Li, Pu Chu, Rongzhan Guan, Tuanjie Zhao   +7 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Mitochondrial heat shock protein 70, a molecular chaperone for proteins encoded by mitochondrial DNA [PDF]

, 1994
Mitochondrial heat shock protein 70 (mt-Hsp70) has been shown to play an important role in facilitating import into, as well as folding and assembly of nuclear-encoded proteins in the mitochondrial matrix.
Herrmann, Johannes M., Stuart, Rosemary A., Neupert, Walter, Craig, Elisabeth A.   +3 more
core   +2 more sources

Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle [PDF]

, 2015
Background Domestication of the now-extinct wild aurochs, Bos primigenius, gave rise to the two major domestic extant cattle taxa, B. taurus and B. indicus.
Magee, DA, Murphy, A., Lohan, AJ, Braud, Martin, Rue-Albrecht, K, Edwards, C.J., Schroeder, Steven, Park, S.D.E., Teasdale, Matthew D., McGettigan, Paul A., Mark, Donoghue, Braud, M, Murphy, Alison, Chamberlain, AT, Bradley, D.G., Chamberlain, Andrew, Liu, Yuan, McGettigan, PA, Lohan, A.J., Spillane, C, Magee, David A., Sonstegard, Tad S., Tai, S, Liu, Y, MacHugh, DE, Murphy, A, School of Earth and Environmental Sciences, Schroeder, S, Tai, Shuaishuai, Bradley, Daniel G., Spillane, Charles, Donaghue, M.T., Park, SD, Braud, M., Loftus, Brendan J., Park, Stephen D E, Chamberlain, Andrew T., Loftus, BJ, MacHugh, David E., Park, Stephen D. E., Bradley, DG, Donoghue, Mark T., Lohan, Amanda J., Teasdale, M.D., Liu, Y., McGettigan, P.A., Teasdale, MD, Magee, D.A., Sonstegard, TS, Donoghue, MT, Edwards, CJ, University of Dublin Trinity College, Rue-Albrecht, Kévin, Chamberlain, A.T., Edwards, Ceiridwen J.   +54 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Recombinant Mitochondrial Transcription Factor A with N-terminal Mitochondrial Transduction Domain Increases Respiration and Mitochondrial Gene Expression in G11778A Leber's Hereditary Optic Neuropathy Cybrid Cells [PDF]

, 2008
Diseases involving mitochondrial defects usually manifest themselves in high-energy, post-mitotic tissues such as brain, retina, skeletal and cardiac muscle and frequently cause deficiencies in mitochondrial bioenergetics.
James P. Bennett, Ravindar R. Thomas, Shilpa Iyer, Francisco R. Portell, Caitlin K. Quigley, Lisa D. Dunahm   +5 more
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Mitochondrial genome organization and phylogeny of two vespid wasps

, 2008
We sequenced the entire mitochondrial genome of Abispa ephippium (Hymenoptera: Vespoidea: Vespidae: Eumeninae) and most of the mitochondrial genome of Polistes humilis synoecus (Hymenoptera: Vespoidea: Vespidae: Polistinae).
Ruberu, Kalani, Ruberu, K., Dowton, Mark, Dowton, M., Castro, Lyda, Diement, Kieren, Stevens, Julia, Castro, L., Austin, A., Whiting, M., Cameron, S., Austin, Andy, Diement, K., Stevens, J., Cameron, Stephen, Whiting, Michael   +15 more
core   +1 more source